Immunologic Research

, Volume 11, Issue 2, pp 81–90 | Cite as

Tumor necrosis factor receptors-structure and function

  • Joachim Rothe
  • Gisela Gehr
  • Hansruedi Loetscher
  • Werner Lesslauer
TNF Receptors

Abstract

Tumor necrosis factors (TNFs) have been a focus of research for well over a decade now. The identification and recent molecular cloning of two different types of cell-surface TNF receptors will shed further light on the mode of action of these pleiotropic cytokines. In the present article, we summarize the data on the biochemistry and structure of the receptors and focus on the molecular cloning of the respective cDNAs. The nucleotide sequences of the receptor genes revealed that both TNF receptors belong to the still growing nerve growth factor receptor gene family. The function and orgin of TNF inhibitory proteins as well as receptor-mediated signal transduction are discussed.

Key Words

Tumor necrosis factor, receptors and inhibitory proteins Nerve growth factor receptor family Cytokines 

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Copyright information

© Humana Press Inc. 1992

Authors and Affiliations

  • Joachim Rothe
    • 1
  • Gisela Gehr
    • 1
  • Hansruedi Loetscher
    • 1
  • Werner Lesslauer
    • 1
  1. 1.F. Hoffmann-La Roche, Ltd.BaselSwitzerland

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