Immunologic Research

, 14:58

Superantigenic characteristics of mouse mammary tumor viruses play a critical role in susceptibility to infection in mice

  • Carlo E. M. Pucillo
  • Larry D. Palmer
  • Richard J. Hodes
Article

DOI: 10.1007/BF02918497

Cite this article as:
Pucillo, C.E.M., Palmer, L.D. & Hodes, R.J. Immunol Res (1995) 14: 58. doi:10.1007/BF02918497

Abstract

Mouse mammary tumor viruses (MMTV) are retroviruses that induce mammary carcinomas. An interesting feature of these viruses is the superantigen (SAg) encoded in an open reading frame within the 3′ long terminal repeat. The mechanism by which ingestion of milk-borne virus results in infection of the host mammary tissue remains incompletely understood. However, a working model has been proposed in which the interaction between viral SAg, T-cell receptor and MHC class II I-E facilitates viral replication and hence infectivity. In this review we summarize current studies demonstrating the role of SAg stimulation in susceptibility to MMTV infection.

Key Words

Mouse mammary tumor virus Superantigen MHC class II T-cell receptor Transgene 

Copyright information

© Humana Press Inc. 1995

Authors and Affiliations

  • Carlo E. M. Pucillo
    • 1
  • Larry D. Palmer
    • 1
  • Richard J. Hodes
    • 1
  1. 1.Experimental Immunology Branch, National Cancer Institute and National Institute on AgingNational Institutes of HealthBethesdaUSA

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