Immunologic Research

, Volume 14, Issue 1, pp 1–12

Lifespan of lymphocytes

  • David F. Tough
  • Jonathan Sprent
Article
  • 460 Downloads

Abstract

T and B lymphocytes comprise heterogeneous populations of cells at various stages of differentiation and activation. T-and B-cell subsets have different roles in the maintenance of immune homeostasis, and their functional differences are reflected by their respective lifespans. This review briefly summarizes the available data on lymphocyte lifespan, including the kinetics of T- and B-cell development in the primary lymphoid organs and the proliferative behavior of naive, effector and memory lymphocytes in the peripheral lymphoid compartment.

Key Words

Lymphocyte lifespan Immune memory Bromodeoxyuridine T-cell turnover B-cell turnover 

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Copyright information

© Humana Press Inc. 1995

Authors and Affiliations

  • David F. Tough
    • 1
  • Jonathan Sprent
    • 1
  1. 1.Department of Immunology, IMM4Scripps Research InstituteLa IollaUSA

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