Immunologic Research

, Volume 9, Issue 2, pp 115–122

Ancestral polymorphisms of MHC class II genes: Divergent allele advantage

  • Edward K. Wakeland
  • Stefen Boehme
  • Jin Xiong She
  • Cheng-Chan Lu
  • Richard A. McIndoe
  • Ivan Cheng
  • Ying Ye
  • Wayne K. Potts
MHC Class II Genes and Molecules, Symposium (Part II)


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Buus S, Sette A, Grey HM: The interaction between protein-derived immunogenic peptides and Ia. Immunol Rev 1987;98:115–141.PubMedCrossRefGoogle Scholar
  2. 2.
    Allen PM, Babbitt BP, Unanue ER: T-cell recognition of lysozyme: the biochemical basis of presentation. Immunol Rev 1987;98:171–187.PubMedCrossRefGoogle Scholar
  3. 3.
    Babbitt BP, Allen PM, Matsueda G, et al: Binding of immunogenic peptides to Ia histocompatibility molecules. Nature 1985;317:350–361.CrossRefGoogle Scholar
  4. 4.
    Guillet J, Lai M, Briner TJ, et al: Immunological self, nonself discrimination. Science 1987;235: 865–870.PubMedCrossRefGoogle Scholar
  5. 5.
    Benacerraf B: A hypothesis to relate the specificity of T lymphocytes and the activity of I region-specific Ir genes in macrophages and B lymphocytes. J Immunol 1978;120:1809–1812.PubMedGoogle Scholar
  6. 6.
    Kappler JW, Roehm N, Marrack P: T cell tolerance by clonal elimination in the thymus. Cell 1987;49:273–280.PubMedCrossRefGoogle Scholar
  7. 7.
    Uhr JW, Capra JD, Vitetta ES, et al: Organization of the immune response genes. Science 1979;206: 292–297.PubMedCrossRefGoogle Scholar
  8. 8.
    Bjorkman PJ, Saper MA, Samraoui B, et al: Structure of the human class I histocompatibility antigen, HLA-A2. Nature 1987;329:506–512.PubMedCrossRefGoogle Scholar
  9. 9.
    Brown JH, Jardetzky T, Saper MA, et al: A hypothetical model of the foreign antigen binding site of Class II histocompatibility molecules. Nature 1988;332:845–850.PubMedCrossRefGoogle Scholar
  10. 10.
    Klein J: Natural History of the Major Histocompatibility Complex. New York, Wiley, 1986.Google Scholar
  11. 11.
    Wakeland EK, Klein J: The histocompatibility-2 system in wild mice. VII. Serological analysis of 29 wild-derived H-2 haplotypes using antisera to inbred I-region antigens. Immunogenetics 1979;8: 27–39.CrossRefGoogle Scholar
  12. 12.
    Gotze D, Nadeau J, Wakeland EK, et al: Histocompatibility-2 system in wild mice. X. Frequencies of H-2 and Ia antigens in wild mice from Europe and Africa. J Immunol 1980;124:2675–2681.PubMedGoogle Scholar
  13. 13.
    Benoist CO, Mathis DJ, Kanter MR, et al: Regions of allelic hypervariability in the murine A alpha immune response gene. Cell 1983;34:169–177.PubMedCrossRefGoogle Scholar
  14. 14.
    Estess P, Begovich AB, Koo M, et al: Sequence analysis and structure-function correlations of murine q, k, u, s and f haplotype I-A beta cDNA clones. Proc. Natl. Acad. Sci. USA 1986;83:3594–3598.PubMedCrossRefGoogle Scholar
  15. 15.
    Potts WK, Manning CJ, Peck AB, et al: Can heterozygote advantage account for the maintenance of H-2 polymorphism?; in David CS (ed): Major histocompatibility genes and their role in immune function, New York, Plenum Press, 1988, vol. 154, pp 89–102.Google Scholar
  16. 16.
    Klitz W, Thomson G, Bau MP: Contrasting evolutionary histories among tightly linked HLA loci. Am J Hum Genet 1986;39:340–349.PubMedGoogle Scholar
  17. 17.
    Saiki RK, Bugawan TL, Horn GT, et al: Analysis of enzymatically amplified beta-globin and HLA-DQ alpha DNA with allele-specific oligonucleotide probes. Nature 1986;324:163–166.PubMedCrossRefGoogle Scholar
  18. 18.
    Bonhomme F: Evolutionary relationships in the genus Mus. Curr Top Microbiol Immunol. 1986; 127:19–34.PubMedGoogle Scholar
  19. 19.
    Felsenstein J: Numerical methods for inferring evolutionary trees. Q Rev Biol 1982;57:379–404.CrossRefGoogle Scholar
  20. 20.
    McConnell TJ, Talbot WS, McIndoe RA, et al: The origin of MHC class II gene polymorphism within the genus Mus. Nature 1988;332:651–654.PubMedCrossRefGoogle Scholar
  21. 21.
    Wakeland EK, Tarnuzzer RW, Lu CC, et al: The evolution of MHC class II genes within the genusMus; in David C (ed): H-2 Genes, Antigens, and Functions. New York, Plenum Press, 1988, vol. R154, pp 139–156.Google Scholar
  22. 22.
    Wakeland EK, Klein J: The polymorphism of I-region encoded antigens among wild mice; in Reisfeld R, Ferone S (ed): Current Trends in Histocompatibility, vol. 4, New York, Plenum Press, 1981, pp 289–304.Google Scholar
  23. 23.
    Wakeland EK, Darby BR: Recombination and mutation of class II histocompatibility genes in wild mice. J Immunol 1983;131:3052–3057.PubMedGoogle Scholar
  24. 24.
    Wakeland EK, Klein J: Evidence for minor structural variations of class II genes in wild and inbred mice. J Immunol 1983;130:1280–1287.PubMedGoogle Scholar
  25. 25.
    Vu TH, Tacchini-Cottier FM, Day CE, et al: Molecular basis for the defective expression of the mouse E beta w17 gene. J Immunol 1988;141: 3654–3660.PubMedGoogle Scholar
  26. 26.
    Figueroa F, Gunther E, Klein J: MHC polymorphism pre-dating speciation. Nature 1988;335: 265–267.PubMedCrossRefGoogle Scholar
  27. 27.
    Duncan WR, Wakeland EK, Klein J: Heterozygosity of H-2 loci in wild mice. Nature 1979;281: 603–605.PubMedCrossRefGoogle Scholar
  28. 28.
    Bodmer WF: Evolutionary Significance of the HL-A System. Nature 1972;237:139–145.PubMedCrossRefGoogle Scholar
  29. 29.
    Zinkernagel RM, Doherty PC: Immunological surveillance against altered self components by sensitised T lymphocytes in lymphocytic choriomeningitis. Nature 1974;251:547–548.PubMedCrossRefGoogle Scholar
  30. 30.
    Wakeland EK, Nadeau JH: Immune responsiveness and polymorphism of the major histocompatibility complex: an interpretation; in Sercarz EE, Cunningham AJ (ed): Strategies of Immune Regulation. New York, Academic Press, 1980, pp 149–156.Google Scholar
  31. 31.
    Benacerraf B, Germain RN: The immune response genes of the major histocompatibility complex. Immunol Rev 1978;38:70.PubMedCrossRefGoogle Scholar
  32. 32.
    Klein J: Generation of diversity at MHC loci: implications for T-cell receptor repertoires; in Fougereau M, Dausset J (ed): Immunology 80, London, Academic Press, 1980.Google Scholar

Copyright information

© Humana Press Inc. 1990

Authors and Affiliations

  • Edward K. Wakeland
    • 1
  • Stefen Boehme
    • 1
  • Jin Xiong She
    • 1
  • Cheng-Chan Lu
    • 1
  • Richard A. McIndoe
    • 1
  • Ivan Cheng
    • 1
  • Ying Ye
    • 1
  • Wayne K. Potts
    • 1
  1. 1.Laboratory of Molecular Biology Department of Pathology and Laboratory MedicineUniversity of FloridaGainesville(USA)

Personalised recommendations