High dose antioxidant supplementation to MS patients

Effects on glutathione peroxidase, clinical safety, and absorption of selenium
  • Jesper Mai
  • Per Schmidt Sørensen
  • Jens Carl Hansen


High-dose antioxidant supplementation has recently been recommended for multiple sclerosis (MS) patients. This study tests the clinical safety, the glutathione peroxidase (GSH-px) activity, and the absorption of selenium during such supplementation. Eighteen MS patients were given 6 tablets especially made for this study, equivalent to 6 mg sodium selenite, 2 g vitamin C, and 480 mg vitamin E a day for five wk. GSH-px, which was lower than in non-MS controls before the start of treatment, increased fivefold during 5 wk of treatment. Side effects were scarce. Ten MS patients were subjected to a 24-h selenium absorption study after ingestion of 2 active tablets, equivalent to 2 mg sodium selenite. Selenium, which was low initially, increased 24% during the first 3 h and then stabilized. It is concluded that the tested antioxidant treatment seems to be safe and that MS patients have low GSH-px, which may be increased by the tested antioxidant treatment.

Index Entries

Multiple sclerosis glutathione-peroxidase sodium selenite vitamin C vitamin E 


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Copyright information

© The Humana Press Inc. 1990

Authors and Affiliations

  • Jesper Mai
    • 1
  • Per Schmidt Sørensen
    • 1
  • Jens Carl Hansen
    • 2
  1. 1.Department of NeurologyÅrhus KommunehospitalÅrhusDenmark
  2. 2.Institute of HygieneÅrhus UniversityÅrhusDenmark

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