Indian Journal of Clinical Biochemistry

, Volume 21, Issue 1, pp 205–207 | Cite as

Tumor necrosis factor alpha (TNF-α) and estrogen hormone in osteoarthritic female patients

  • Pradeep Sharma
  • Neelima Singh
  • Vinod Singh
  • Sanjeev Singh
  • Harsh vardhan Singh
  • Sameer Gupta


Osteoarthritis of knee joints is a disease of old age in both sex. It is very common after the age of 40 years in elderly females or in postmenopausal phase of females. It is characterized by narrowing of space in joints due to inflammation. The exact mechanism of inflammation in this disease is not yet clear. Tumor necrosis factor alpha (TNF-α) may involve in onset of disease. The present study is being carried out in 130 female subject of age group 40–60 years suffering from osteoarthritis of knee joints and 50 normal healthy control female subjects. A correlation is made between TNF-α and estrogen and found significant inverse correlation (r<0.001), between TNF-α and estrogen hormone in osteoarthritic female patients as compared to normal healthy control female group.


TNF-α Estrogen hormone Osteoarthritis (OA) 


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  1. 1.
    Moheu, E., Dreiser, R.L., Guillou, G.B. and Dewailly, J. (2000). Hand osteoarthritis patients characteristics according to the existence of hormone replacement therapy. Osteoarthritis cartilage. 8 (suppl. A), 533–537.Google Scholar
  2. 2.
    Vonmuhlen, D., Morton, D., Vonmuhlen, C.A. and Barrett-conmore, E. (2002). Postmenopausal estrogen and increased risk of clinical osteoarthritis at the hip, hand, and knee in older women. Journal of women health. 6, 511–518.Google Scholar
  3. 3.
    Masahiko, Kobayashi, Ginette, R., Squires, Aisha, Mousa, Michael Tanzer, Davidm, J., Zukor, John Antoniou, Ulrich, Feique A., Robin, Poole (2005). Role of interleukin-1 and tumor necrosis factor alpha in matrix degradation of human osteoarthritic cartilage. Arthritis and Rheumatism. 52, 128–135.CrossRefGoogle Scholar
  4. 4.
    Sunyer, Tersa, Lewis, Jennifer, Collinosdoby, Patricia and Osdoby, Philip (1999). Estrogen bone protective effects may involve differential IL-1 receptors regulation in human osteoclast cell. Journal of clinical investigation 103 (10), 1409–1420.PubMedCrossRefGoogle Scholar
  5. 5.
    Rogers A. and Eqstell, R. (1998). Effects of estrogen therapy of postmenopausal women on cytokines measured in peripheral blood. Journal of Bone Mineral Research 13 (10), 1577–1586.CrossRefGoogle Scholar
  6. 6.
    Iannone, F. and Lapadula, G. (2003). The pathophysiology of osteoaerthritis. Aging Clinical Experimental Research 15 (5), 364–372.Google Scholar
  7. 7.
    Piere, Pelletier, Robert, Mccollum, Jean, Mariecloutier and Jhanne, Martelpelletier (1995). Synthesis of metalloproteases and interleukin-6 (IL-6) in human osteoarthritic synovial membrane is an IL-1 mediated process. Journal of Rheumatology. 22, 109–114.Google Scholar
  8. 8.
    Fernandes, J.C., Martel-pelletier, J. and Pelletier, J.P. (2002). The role of cytokines in osteoarthritis pathophysiology. Biorheology 39 (12), 237–246.PubMedGoogle Scholar
  9. 9.
    Tetlow, L.C., Adlam, D.J. and Woolley, D.E. (2001). Matrix. Metalloproteinase and proinflammatory cytokine production by osteoarthritic of human osteoarthritic cartilage: association with degenerative changes. Arthritis and Rheumatism 44 (3), 589–594.CrossRefGoogle Scholar
  10. 10.
    Lee, Y.J., Lee, E.B., Kwon, Y.E., Lee, J.J., Cho, W.S., Kim, H.A. and Song, Y.W. (2003). Effect of estrogen on the expression of matrix mettaloproteinase (MMP)-1, MMP-3 and tissue inhibitor of mettaloproteinase-1 in osteoarthritis chondrocytes. Rheumatology Int. 23 (6), 282–288.CrossRefGoogle Scholar
  11. 11.
    Parazini, F. (2003). Menopausal status hormone replacement therapy use and risk of self reported physician-diagnosed osteoarthritis in women attending menopause clinics in Italy. Maturitas 46 (3), 207–212.CrossRefGoogle Scholar
  12. 12.
    Janecauley, A., Kentkwoh, C., Graceegeland, Michael Nevittc, Lawrence, Cooperstein, Jiffrey Rohay, Adele Towers and Jamesgutai, P. (1993). Serum sex hormones and severity of osteoarthritis of the hand. Journal of Rheumatology. 20, 1170–1175.Google Scholar

Copyright information

© Association of Clinical Biochemists of India 2006

Authors and Affiliations

  • Pradeep Sharma
    • 1
  • Neelima Singh
    • 1
  • Vinod Singh
    • 2
  • Sanjeev Singh
    • 1
  • Harsh vardhan Singh
    • 1
  • Sameer Gupta
    • 3
  1. 1.Department of BiochemistryG. R. Medical CollegeGwalior
  2. 2.Department of MicrobiologyCancer Hospital & Research InstituteGwalior
  3. 3.Department of Orthopaedic, J.A. Group of HospitalsG. R. Medical CollegeGwalior

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