Advertisement

Study of lipid peroxide and lipid profile in diabetes mellitus

  • N. P. Suryawanshi
  • A. K. Bhutey
  • A. N. Nagdeote
  • A. A. Jadhav
  • G. S. Manoorkar
Article

Abstract

The study was designed to find out the correlation between lipid peroxidation, lipoprotein levels to severity and complication of diabetes mellitus. Degree of lipid peroxidation was measured in terms of malondialdehyde (MDA) along with lipid profile and blood glucose in diabetes mellitus. It is categorised into insulin dependent diabetes mellitus (IDDM), non insulin dependent diabetes mellitus (NIDDM) and diabetes mellitus(DM) with complication.

Total 112 known diabetic patients and 52 non-diabetic controls were studied. These patients were grouped as per the concentration of fasting blood glucose level i.e. controlled, poorly controlled, and uncontrolled group. There are significant increase in the lipid peroxide (MDA) and lipid profile except HDL cholesterol which is decreased, has been found in all groups as compared to controls In NIDDM group lipid peroxidation was markedly increased than IDDM group and it was higher in DM with complications. Other finding observed was that the level of lipid peroxide increased as per the increase in concentration of blood glucose. The increase lipid peroxidation in the hyperglycemic condition may be explained, as the superoxide dismutase enzyme which is antioxidant becomes inactive due the formation of superoxide radical within the cell. Maximum lipid peroxidation leads to the damage of the tissue and organs which results into complication in diabetic patients. High levels of total cholesterol appear due to increased cholesterol synthesis. The triglyceride levels changes according to the glycemic, control. The increase may be due to overproduction of VLDL-TG.

It is concluded that good metabolic control of hyperglycemia will prevent in alteration in peroxidation and the lipid metabolism, which may help in good prognosis and preventing manifestation of vascular and secondary complication in diabetes mellitus.

Key words

Malondialdehyde Lipid Peroxide Diabetes Mellitus 

References

  1. 1.
    Altamer, E., Vendemisle, G. and Chicco, D. (1991). Increased lipid peroxidation in Type-II poorly control Diabetic patients. Diabete. Etab. 18 (4), 264–671.Google Scholar
  2. 2.
    Jain, A.P. and Gupta, D.P. (1980). Study of blood lipids in Diabetics without any manifest vascular complications. J. Dia. Asso. Ind. Vol. XX, 29–34.Google Scholar
  3. 3.
    Agrawal, S., Banerjee, S. and Chatterjee, S. N. (1985). Effects of oxygen on ferrous sulphate induced lipid peroxidation in liposomal membrane. Ind. J. Biochem. and Biophysics. 21, 331–334.Google Scholar
  4. 4.
    Chattergee, S.N., Agrawal, S. and Amitkumar (1988). Membrane lipid peroxidation and its pathological consequence. Ind. J. of Biochem and Biophysics. 25, 31.Google Scholar
  5. 5.
    Tappel, A.L. (1973). Lipid peroxidation damage to cell components. Clinical pathology. Federation proceeding 32 (8), 1870–1874.Google Scholar
  6. 6.
    Yuzo, Sato, Migishi, Hotta and Nabuo, Sakamoto (1979). Lipid peroxide level in plasma of Diabetic patients. Biochemical Medicine 21, 104–107.CrossRefGoogle Scholar
  7. 7.
    Nishigaki, Ikua, Masako, Hagihara and Hiroshi Tsunekawo (1981). Lipid peroxide level and serum lipoprotein fractions in Diabetics patients. Biochemical Medicine 25, 373–378.PubMedCrossRefGoogle Scholar
  8. 8.
    Chandilia, H.B., Talwalkar, B.S. and Rajha, B.S. (1988). Lipid profiles in Diabetes mellitus. J. Dia. Assoc. India 21, 155.Google Scholar
  9. 9.
    Stalenhoef, A.F.H., Demacker, P.N.M. and Lutterman, J.A. (1978). High Density lipoprotein and maturity onset Diabetes. Prog. Lipid Res. 32, 1–24.Google Scholar
  10. 10.
    Taniguchi, Naoyuki (1992). Clinical significance of superoxide dismutase, Change in aging, Diabetes, Ischemia and Cancer. Advance in clini. chem., 29, 1–47.Google Scholar
  11. 11.
    Suckling, Keith E. and Brian, Jackson (1993). Animal Models of Human lipid Metabolism. Prog. lipid. Res. 32, 124.Google Scholar
  12. 12.
    Freitas, J.P., Filipe, P.M. and Radrigo, F.G. (1997). Lipid peroxidation in Type-II normolipidemic diabeticpatients Diabetes. Res. Practy. 36 (2), 71–75.Google Scholar
  13. 13.
    Velazquez, E., Winocour, P.H., Kestenen, P.et al. (1991). Relation of lipid peroxide to macrovascular diseases in type-II Diabetes. Diabetic Medicine 8, 752–758.PubMedCrossRefGoogle Scholar
  14. 14.
    Shih, K.C., Kwak, C.F. and Hwa, C.M. (1997). Acipimox attenuates hypertriglyceredemia in Dislipidemic Non-insulin dependent diabetes mellites patients without perturbation of insulin sensitivity and glycemic, control. Diabetic. Res. clin. pract. 36 (2), 113–119.CrossRefGoogle Scholar
  15. 15.
    Das, Siddartha, Samal, Khitish Chandram and Tripathy, Bibhuti Bhashnt (1992). Factors influencing plasma lipids and lipoprotein cholesterol in Indian NIDDM J. Dia. Assoc. Ind. 32 (2).Google Scholar
  16. 16.
    Yogi, K.et al. (1999). Lipid peroxide and human diseases. Chemistry and Physics of Lipids 45, 337–351.CrossRefGoogle Scholar

Copyright information

© Association of Clinical Biochemists of India 2006

Authors and Affiliations

  • N. P. Suryawanshi
    • 1
  • A. K. Bhutey
    • 1
  • A. N. Nagdeote
    • 1
  • A. A. Jadhav
    • 1
  • G. S. Manoorkar
    • 1
  1. 1.Department of BiochemistryIndira Gandhi Govt. Medical College and Mayo HospitalNanded

Personalised recommendations