Archives of Pharmacal Research

, Volume 12, Issue 4, pp 236–238 | Cite as

Pharmacological activities of the constituents of atractylodes rhizomes

  • Kwan Seog Sin
  • Hyun Pyo Kim
  • Woo Cheol Lee
  • P. Pachaly
Original Articles


The anti-microbial and anti-inflammatory activities of the constituents from Atractylodes rhizomes were evaluated. Atractylone showed anti-microbial activity. Atractylone and atractylenolide I possessed considerable anti-inflammatory activity utilizing rat cotton pellet granuloma bioassay.


atractylone atractylenolide I atractylenolide III anti-microbial and anti-inflammatory activity 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literature Cited

  1. 1.
    Yen, K. Y.: The illustrated Chinese Materia Medica Crude Drugs. Southern Materials Center (Taiwan) p. 89 (1980).Google Scholar
  2. 2.
    Nisikawa, Y., Watanabe, Y., Seto, T. and Yasuda, I.: Studies on the components of Atractylodes.Yakugaku Zasshi 96, 1086 (1976).Google Scholar
  3. 3.
    Kiso, Y., Tohkin, M. and Hikino, H.: Validity of the oriental medicines. 72. Liver protective drugs. 17. Mechanism of anti-hepatotoxic activity of atractylone.Planta Med. 51, 97 (1985).PubMedCrossRefGoogle Scholar
  4. 4.
    Pachaly, P., Lansing, A. and Sin, K.S.: Constituents of Atractylodeskoreana.Planta Med. 55, 59 (1989).PubMedCrossRefGoogle Scholar
  5. 5.
    Endo, K., Taguchi, T., Hikino, H., Yamahara, J. and Fuzimura, H.: Anti-inflammatory principles of Atractylodes rhizomes.Chem. Pharm. Bull. 27, 2954 (1979).PubMedGoogle Scholar
  6. 6.
    Hikino, H., Hikino, Y. and Yoshioka, Y.: Constituents ofAtractylodes. IX. Structure and autooxidation of atractylon.Chem. Pharm. Bull. 12, 755 (1964).PubMedGoogle Scholar
  7. 7.
    Kim, H.P., Bird, J., Heiman, A.S., Hudson, G.F., Taraporewala, I.B. and Lee, H.J.: Synthesis of new anti-inflammatory steroidal 20-carboxamides.J. Med. Chem. 30, 2239 (1987).PubMedCrossRefGoogle Scholar

Copyright information

© The Pharmaceutical Society of Korea 1989

Authors and Affiliations

  • Kwan Seog Sin
    • 1
  • Hyun Pyo Kim
    • 1
  • Woo Cheol Lee
    • 2
  • P. Pachaly
    • 3
  1. 1.College of PharmacyKangweon National UniversityChuncheonKorea
  2. 2.Department of Biology ScienceKangweon National UniversityChuncheonKorea
  3. 3.Pharmazeutisches Institute der Universität BonnWest Germany

Personalised recommendations