Economic Botany

, Volume 8, Issue 4, pp 349–365 | Cite as

Rauvolfia serpentina—Its history, botany and medical use

  • Joseph Monachino


This small shrub, native to the Orient from India to Sumatra, has for centuries been used in Indian medicine. In 1952 reserpine, one of several alkaloids in the plant, was isolated from its root and has since been evaluated in western medicine as one of the most valuable druǵs for treatinǵ hiǵh blood pressure.


Alkaloid Economic Botany Reserpine Total Alkaloid Cyme 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. Anet, F. A. L., Mukherji, D., Robinson, R., and Schlittler, E. Ajmaline. Part I. Chem. & Ind.20: 442. 1952.Google Scholar
  2. Arnold, O. H., and Bock, K. D. New results in the pharmaceutical treatment of arterial hyperteLsion. Deut. med. Wochschr.78: 879–883. 1953.CrossRefGoogle Scholar
  3. Baillon, H. Histoire des Plantes. Vol.10: 171. 1891.Google Scholar
  4. Bakshi, V. M. Determination of serpentina alkaloids. Indian Jour. Pharm.22: 172. 1950.Google Scholar
  5. Basu, B. D. [Ed.]. Kirtikar—Indian Medicinal Plants, t. 602. 1918. [Fide Index Londinensis].Google Scholar
  6. Bauhin, C. Pinax Theatri Botanici. p. 301. 1671.Google Scholar
  7. Bein, H. J. Reserpin. 2. The pharmacology of reserpin, a new alkaloid fromRauwolfia serpentina Benth. Experientia9: 107–110. 1953.PubMedGoogle Scholar
  8. Bhatia, B. B. On the use ofRauwolfia serpentina in high blood pressure. Jour. Indian Med. Assoc.11: 262–265. 1942.Google Scholar
  9. — and Kapur, R. D. Pharmacological action of alkaloids ofRauwolfia serpentina Benth. I. Neo-ajmaline and iso-ajmaline. Indian Jour. Med. Res.32: 177–182. 1944.Google Scholar
  10. Bodendorf, K., Eder, H., Achelis, J. D., and Kroneberg, G. Raupin, a new alkaloid fromRauwolfia serpentina. Pharmacologic testing. Naturwiss.40: 342. 1953.Google Scholar
  11. Boer, S. de. Die Wirkung von Rauwolfin auf das Herz und auf das Flimmern einer Herzabteilung. Cardiologia1: 1–8. 1937.CrossRefGoogle Scholar
  12. Burkill, I. H. The botany of the Abor Expedition. Rec. Bot. Sur. India10(2): 319. 1925.Google Scholar
  13. Burman, J. Thesaurus Zeylanicus. p. 141, t.64. 1737.Google Scholar
  14. Chakravarti, M. D. Indian medicinal plant in the treatment of hypertension. Brit. Med. Jour,1: 1390. 1953.Google Scholar
  15. Chakravarty, N. K., Chaudhuri, M. N. Rai, and Chaudhuri, R. N.Rauwolfia serpentina in essential hypertension. Indian Med. Gaz.86: 348–354. 1951.Google Scholar
  16. Chatterjee, A., and Bose, S. A new alkaloid from the root ofRauwolfia serpentina. Sci. & Cult.17: 139. 1951.Google Scholar
  17. Chopra, R. N. Indigenous drugs of India, p. 373. 1933.Google Scholar
  18. —, Bose, B. C., and Gupta, J. C. Alkaloids ofRauwolfia serpentina: comparative study of their pharmacological action and their role in experimental hypertension. Indian Jour. Med. Res.30: 319–324. 1942.Google Scholar
  19. — and Chakravarti, M. Preliminary note on the pharmacological action of the alkaloids ofRauwolfia serpentina. Indian Jour. Med. Res.29: 763–768. 1941.Google Scholar
  20. —, Das, N. N., and Mukherjee, S. N. The action of ajmaline on nerve impulses. Indian Jour. Med. Res.24: 1125. 1937.Google Scholar
  21. —, Gupta, J. C., Bose, B. C., and Chopra, I. C. Hypnotic effect ofRauwolfia serpentina: the principle underlying this action; its probable nature. Indian Jour. Med. Res.31: 71–74. 1943.Google Scholar
  22. —, —, and Mukherjee, B. Pharmacological action of alkaloid obtained fromRauwolfia serpentina Benth.; preliminary note. Indian Jour. Med. Res.21: 261. 1933.Google Scholar
  23. Chowhan, J. S. “ Insanity herbs ”(Rauwolfia serpentina Benth.). Antiseptic39: 26. 1942.Google Scholar
  24. Ciba, Summit, N. J. Serpasil.18 pp. [Undated: 1953 or 1954].Google Scholar
  25. Cooke, T. The flora of the Presidency of Bombay. Vol.2: 127. 1905.Google Scholar
  26. Cowan, A. M., and Cowan, J. M. The trees of northern Bengal, including shrubs, woody climbers, bamboos, palms and tree ferns, p.89. 1929.Google Scholar
  27. Craib, W. G. Contributions to the Flora of Siam. Dicotyledons, p.129. 1912.Google Scholar
  28. Dalzell, N. A., and Gibson, A. The Bombay flora, pp. 143–144. 1861.Google Scholar
  29. De, M. N., and. Chatterjee, T. Combined digitalis and rauwolfia poisoning in human subject. Indian Med. Gaz.76: 724. 1941.Google Scholar
  30. Deb, A. K. The role ofRauwolfia serpentina in treatment of mental disorders. Indian Med. Res.63: 359–360. 1943.Google Scholar
  31. Dorfman, L., Huebner, C. F., MacPhillamy, H. B., Schlittler, E., and St. André, A. F. On the constitution of reserpine fromRauwolfia serpentina Benth. Experientia9: 368–369. 1953.PubMedGoogle Scholar
  32. Drury, H. Handbook of the Indian flora. Vol.2: 190–191. 1866.Google Scholar
  33. Duthie, J. F. Flora of the Upper Gangetic Plain and of the adjacent Siwalik and sub-Himalayan tracts. Vol.2: 33. 1911.Google Scholar
  34. Dutt, A., Gupta, J. C., Ghosh, S., and Kahali, B. S.Rauwolfia serpentina. Indian Jour. Pharm.9: 54–57. 1947.Google Scholar
  35. Dymock, W. Notes on Indian drugs. Pharm. Jour. & Trans. III.10: 281. 1879.Google Scholar
  36. -. The vegetable materia medica of western India, pp. 420–421. 1884.Google Scholar
  37. Fischer, C. E. C. A survey of the flora of the Anaimalai Hills in the Coimbatore District, Madras Presidency. Rec. Bot. Sur. India9: 113. 1921.Google Scholar
  38. —. The flora of the Lushai Hills. Rec. Bot. Sur. India12: 111. 1938.Google Scholar
  39. Furlenmeier, A., Lucas, R., MacPhillamy, H. B., Miiller, J. M., and Schlittler, E. On the constitution of reserpine. Experientia9: 331–333. 1953.PubMedGoogle Scholar
  40. Gaertner, J. Fructibus et Seminibus Plantarum. Vol.2: 129, t. 109. 1791.Google Scholar
  41. Garcin, A. G. Recherches sur les Apocynées. pp. 220–223. 1889.Google Scholar
  42. Government of India, Dept. of Health. The Indian Pharmacopeial List, 1946, pp. 78–79, 157–159. 1950.Google Scholar
  43. Greshoff, M. Mittheilungen aus dem chemisch-pharmakologischen Laboratorium des botanischen Gartens zu Buitenzorg (Java). Ber. Deut. Chem. Ges.23: 3543. 1890.Google Scholar
  44. -. Nuttige Indische Planten. t.46. 1900. [Fide Index Londinensis.]Google Scholar
  45. —.Rauwolfia serpentina Benth. Ind. Mercuur23: 383–384, t. 1900.Google Scholar
  46. Gupta, J. C., Deb, A. K., and Kahali, B. S. Preliminary observations on use ofRauwolfia serpentina Benth. in treatment of mental disorders. Indian Bed. Gaz.78: 547–549. 1943.Google Scholar
  47. —, Ghosh, S., Dutt, A. T., and Kahali, B. S. Hypnotic principle ofRauwolfia serpentina. Jour. Am. Pharm. Assoc, Sci. Ed.36: 416. 1947.Google Scholar
  48. — and Kahali, B. S. Comparative pharmacology of the total alkaloids ofRauwolfia serpentina Benth. obtained from Bengal, Bihar, and Dehra Dun. Indian Jour. Med. Res.31: 215–219. 1943.Google Scholar
  49. —, —, and Dutt, A. The hypnotic effect of a resin fraction isolated from root ofRauwolfia serpentina Benth. obtained from Dehra Dun. Indian Jour. Med. Res.32: 183–188. 1944.Google Scholar
  50. —, Roy, P. K., and Ray, G. K. A preliminary note on the excretion ofRauwolfia total alkaloids in urine. Indian Jour. Med. Res.38: 67. 1950.Google Scholar
  51. Haines, H. H. The botany of Bihar and Orissa. Vol.4: 539. 1922.Google Scholar
  52. Hartog, J. Die Wirkung von Rauwolfin auf das Herz. Arch. Int. Pharmacodynamie et Therapie51: 10–14. 1935.Google Scholar
  53. Henry, T. A. The plant alkaloids. 3rd ed. pp. 626–628. 1939.Google Scholar
  54. Hensler, L. Treatment of hypertension with Serpasil, aRauwolfia serpentina alkaloid. Schweiz. m. Wochschr.83: 1162–1166. 1953.Google Scholar
  55. Heyne, K. Die nuttige planten van Nederlandach-Indië. 2nd ed. Vol.2: 1286–1287, 1221. 1927.Google Scholar
  56. Hörhammer, L., Hänsel, R., and Rao, S. B. Zur Bestimmung der Alkaloide ausRauwolfia serpentina (Benth.). Naturwiss.39: 553. 1952.Google Scholar
  57. Hooker, J. D. The flora of British India. Vol.3: 632. 1882.Google Scholar
  58. Itallie, L. van, and Steenhauer, A. J.Rauwolfia serpentina Benth. Pharm. Weekblad69: 334. 1932.Google Scholar
  59. Jacquin, N. J. Plantarum Rariorum Horti. . . Schoenbrunnensis . . . Icones. Vol.3: 73, t. 389. 1798.Google Scholar
  60. Kaempfer, E. Amoenitatum Exoticarum. Fasc. 3. Gemina Indorum Antidota. Radix Mungo. pp. 573–578. 1712.Google Scholar
  61. Kapur, R. D.Rauwolfia serpentina—pharmacological action and its value in treatment of hyperpiesia. Jour. Indian Med. Assoc.11: 198–201. 1942.Google Scholar
  62. —. Pharmacological action of alkaloids ofRauwolfia serpentina. II. Total alkaloidal extracts of Bihar and Dehra Dun varieties. Indian Jour. Med. Res.36: 57–60. 1948.Google Scholar
  63. Khory, R. N. The Bombay Materia Medica and their therapeutics, p. 386. 1887.Google Scholar
  64. King, G., and Gamble, J. S. Materials for a flora of the Malayan Peninsula. No. 19, p. 424. 1907.Google Scholar
  65. Klohs, M. W., Draper, M. D., Keller, F., and Petracek, F. J. Alkaloids ofRauwolfia serpentina Benth. I. The characterization of reserpine and its hydrolysis products. Jour. Amer. Chem. Soc.75: 4867. 1953.Google Scholar
  66. Koorders, S. H. Notizen über die Phanerogamenflora von Java. Nat. Tidsschr. Ned. Ind.60: 243. 1901.Google Scholar
  67. Kress, R. Chemical and medicinal aspects ofRauwolfia serpentina Benth. Pharmazie8: 726–728. 1953.PubMedGoogle Scholar
  68. Kurz, S. Forest flora of British Burma. Vol.2: 171. 1877.Google Scholar
  69. Linnaeus, C. Flora Zeylanica. pp. 188, 239. 1747.Google Scholar
  70. -. Materia Medica. p. 168. 1749.Google Scholar
  71. —. Species Plantarum Vol.2: 1043. 1753.Google Scholar
  72. Lamarck, C. de. Tableau Encyclopedique . . . Illustrations des Genres. Vol.2 (pt. 5): t. 842. 1800. Text in Vol.3: 423. 1823.Google Scholar
  73. Mazumdar, D. C., and Mukherji, K. L. Rauwolfia in hypertension. Jour. Indian Med. Assoc.19: 362–367. 1950.Google Scholar
  74. Merrill, E. D. An interpretation of Rumphius’s Herbarium Amboinense. Publ. no. 9, Bureau of Science, Manila, p. 430. 1917.Google Scholar
  75. Miquel, F. A. W. Flora Indiae Batavae. Vol.2: 404–405. 1856.Google Scholar
  76. Mookerjee, A. The alkaloids ofRauwolfia canescens Linn. Jour. Indian Chem. Soc.18: 33. 1941.Google Scholar
  77. Miiller, J. M., Schlittler, E., and Bein, H. J. Reserpin, the sedative principle ofRauwolfia serpentina Benth. Experientia8: 338. 1952.Google Scholar
  78. Mukherji, D., Robinson, R., and Schlittler, E. Chemistry of ajmaline, rauwolfine of Van Itallie and Steenhauer. Experientia5: 215. 1949.PubMedGoogle Scholar
  79. Nairne, A. K. The flowering plants of western India, p. 179. 1894.Google Scholar
  80. Nelson, J. W., and Schlagel, C. A. A preliminary note on a pharmacological investigation of the hypotensive action ofRauwolfia serpentina Benth. Jour. Am. Pharm. Assoc, Sci. Ed.42: 324. 1953.Google Scholar
  81. Neuss, N., Boaz, H. E., and Forbes, J. W. Structure of reserpin. Jour. Am. Chem. Soc.75: 4870–4871. 1953.Google Scholar
  82. Osal, A., and Farrar, G. E. The Dispensatory of the United States of America.24 ed. p. 1569. 1947.Google Scholar
  83. Paranjpe, A. S. Med. Bull.10: 135. 1942. [Fide Vakil.]Google Scholar
  84. Parker, R. N. A forest flora of the Punjab with Hazara and Delhi, p. 331. 1924.Google Scholar
  85. Pichon, M. Classification des Apocynacées II, genreRauvolfia. Bull. Soc. Bot. France94: 31–39. 1947.Google Scholar
  86. Planchon, L. Produits fournis, à la matière médical por la famille des Apocynées. pp. 237–238. 1894.Google Scholar
  87. Plenck, J. J. von. Icones Plantarum Medicinalium, cent, viii, t. 732. 1812. [Fide Index Londinensis].Google Scholar
  88. Plummer, A. J., Barrett, W. E., Wagle, G., and Yonkman, F. F. Sedative and hypnotic action of reserpin in unanesthetized animals. [Am. Soc. Pharmacol. Exp. Theraps., meet. 4/6-10/53]. Fed. Proc.12: 357–358. 1953.Google Scholar
  89. Pool, J. F. A. Bijdrage tot de Kennis van den Anatomischen Bouw van de belangrijkste in Nederlandsch-oost-Indie voorkomende Vergifte Apocynaceae .... Pharm. Weekblad, pp. 104–110, figs. 147–150. 1928.Google Scholar
  90. Prain, D. The vegetation of the districts of Hughli-Howrah and the 24-Pergunnahs. Rec. Bot. Sur. India111: 235. 1905.Google Scholar
  91. Rama Rao, R. S. M. Flowering plants of Travancore. pp. 251–252. 1914.Google Scholar
  92. Ray, G. K., Roy, P. K., Dasgupta, S. R., and Werner, G. The action ofRauwolfia serpentina on vasomotor reflexes. Arch. Exp. Path. Pharmakol.219: 310–314. 1953.Google Scholar
  93. Raymond-Hamet. Sur un nouveau paralysant électif des vasoconstricteurs adrènalinosensibles L’ajmalinine, alcaloïde cristallisè de 1’ “ Ophioxylum serpentinum” Willd. Bull. Acad. Med. [Paris]115: 452–458. 1936.Google Scholar
  94. —. Sur quelques propriétés physiologiques de la serpentine, alcaloïde cristallisé duRauwolfia serpentina Bentham. Compt. Rend. Séan. Soc. Biol.134: 94–96. 1940.Google Scholar
  95. —. Effets intestinaux de l’ajmaline pure. Compt. Rend. Séan. Soc. Biol.134: 369–372. 1940.Google Scholar
  96. —. Influence de la serpentinine sur les effets de l’adrénaline, de l’occulsion carotidienne et de la faradisation du pneumogastrique. Compt. Rend. Heb. Séan. Acad. Sci.211: 414–416. 1940.Google Scholar
  97. —. Ajmaline, serpentine et serpentinine. Compt. Rend. Heb. Séan. Acad. Sci.229: 1165–1166. 1949.Google Scholar
  98. Rheede, H. van. Hortus Malabaricus. Vol.6: 81, t. 47. 1686.Google Scholar
  99. Rose, S. Rauwolfinine, the new alkaloid of the root ofRauwolfia serpentina Benth. Sci. & Cult.18: 98. 1952.Google Scholar
  100. Roxburgh, W. Flora Indica. ed. 1, Vol.2: 530–531. 1824.Google Scholar
  101. Roy, P. K. Effect ofRauwolfia serpentina on manic patients. Indian Jour. Neurol. & Psychiat.2: 59–62. 1950.Google Scholar
  102. Rumphius, G. E. Herbarii Amboinensis Auctuarium. Vol.6: 29–32, t. 16. 1755.Google Scholar
  103. Salisbury, R. A. Prodromus Stirpium in Horto ad Chapel Allerton Vigentium. p. 146. 1796.Google Scholar
  104. Schlittler, E., and Schwarz, H. The alkaloid serpentine fromRauwolfia serpentina. Helv. Chim. Acta33: 1463–1477. 1950.Google Scholar
  105. Schroff, M. L., and Bhatia, R. L. A method of assay ofRauwolfia serpentina. Indian Jour. Pharm.3: 59–61. 1941.Google Scholar
  106. Sen, G., and Bose, K. C.Rauwolfia serpentina, a new Indian drug for insanity and high blood-pressure. Indian Med. World2: 194–201. 1931.Google Scholar
  107. Science News Letter.64: 279, 363. 1953.Google Scholar
  108. Siddiqui, S., and Siddiqui, R. H. Alkaloids ofRauwolfia serpentina Benth. Jour. Indian Chem. Soc.16: 421–422. 1939. [Also 8: 667. 1931; 9: 539. 1932; 12: 37. 1935. Fide Mookerjee.]Google Scholar
  109. Sims, J.Ophioxylum serpentinum. Curtis’s Bot. Mag.20: t. 784. 1804.Google Scholar
  110. Squibb Institute for Medical Research.Rauwolfia serpentina. 4 pp. Additional References, 2 pp. 1953.Google Scholar
  111. Squibb Institute for Medical Research. Raudixin. 26 pp. 1953.Google Scholar
  112. Stachey, R. Catalogue of the plants of Kumaon and of the adjacent portions of Garhwal and Tibet, p. 110. 1906.Google Scholar
  113. Stoll, A., and Hofmann, A. Sarpagin, ein neues Alkaloid ausRauwolfia serpentina Benth. Helv. Chim. Acta36: 1143–1147. 1953.Google Scholar
  114. Talbot, W. A. Systematic list of the trees, shrubs and woody climbers of the Bombay Presidency, p.130. 1894.Google Scholar
  115. Thwaites, G. H. K. Enumeratio Plantarum Zeylaniae. p.191. 1860.Google Scholar
  116. Trapold, J. H., Osborne, M., and Yonkman, F. F. Pharmacological effects of reserpin, a new crystallized pure alkaloid fromRauwolfia serpentina Benth. in the dog. [Am. Soc. Pharmacol. Expt. Theraps., meet. 4/6-10/53). Fed. Proc.12: 373–374. 1953.Google Scholar
  117. Trattinick, L. Auswahl vorzüglich schöner. . . Gartenpflanzen .... Vol.2: 48–49, t. 141. 1821.Google Scholar
  118. Trease, G. E. A text-book of pharmacognosy. 6th ed. p. 475. 1952.Google Scholar
  119. Trimen, H. A handbook to the flora of Ceylon. Vol.3: 126. 1895.Google Scholar
  120. Vakil, R. J. A clinical trial ofRauwolfia serpentina in essential hypertension. Brit. Heart Jour.11: 350–355. 1949.Google Scholar
  121. Wallis, T. E., and Rohatgi, S. The pharmacognosy of Rauwolfia. Jour. Pharm.& Pharmacol.1: 292–305. 1949.Google Scholar
  122. Warden, C. J. H., and Bose, C. L.Rauwolfia serpentina, Benth. Note on certain reactions of an alkaloid contained in the roots. Pharm. Jour. & Trans. III.23: 101–102. 1892.Google Scholar
  123. Watt, G. Dictionary of the economic products of India. Vol.5: 489. 1891; Vol. 6: 398–399. 1892.Google Scholar
  124. Wefers Bettink, H. Over den wortel van Ophioxylon serpentinum (Poeleh padak). Nieuw Tijdschr. Pharm. Nederl.21: 1–20. 1888.Google Scholar
  125. Wehmer, C. Die Pflanzenstoffe. Vol.2: 981. 1931. Suppl. 172. 1935.Google Scholar
  126. Wendland, J. C. Bemerkungen über einige Pflanzen, nebst Abbildungen derselben. Arch. Bot. Römer1: 53–54, t.7, fig.2. 1796.Google Scholar
  127. Wight, R. Icones Plantarum Orientalis. Vol.3:4, t. 849. 1843–1845. Vol.4:2. 1848.Google Scholar
  128. —. Illustrations of Indian botany. Vol.2: 162. 1845–1850.Google Scholar
  129. Wilkins, R. W. New drug therapies in arterial hypertension. Ann. Int. Med.37: 1144–1155. 1952.PubMedGoogle Scholar
  130. —. Current drug treatment of hypertension. Mod. Concepts Cardiovas. Dis.22: 198–201. 1953.Google Scholar
  131. —. Hypertension: recent trends in treatment. Med. Clin. No. Amer.37: 1303–1312. 1953.Google Scholar
  132. — and Judson, W. E. The use of Rauwolfia serpentina in hypertensive patients. New Eng. Jour. Med.248: 48–53. 1953.Google Scholar
  133. Youngken, H. W., Sr. A note onRauwolfia serpentina. Am. Jour. Pharm.125: 186–189, fig. 1. 1953.Google Scholar
  134. —, Sr. A pharmacognostical study ofRauwolfia. Jour. Am. Pharmaceut. Assoc, Sci. Ed.43(2): 70–78, fig. 1-4. 1954.Google Scholar

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© The New York Botanical Garden 1954

Authors and Affiliations

  • Joseph Monachino
    • 1
  1. 1.The New York Botanical GardenUSA

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