Annals of Behavioral Medicine

, Volume 21, Issue 2, pp 180–191 | Cite as

A meta-analysis of fibromyalgia treatment interventions

  • Lynn A. Rossy
  • Susan P. Buckelew
  • Nancy Dorr
  • Kristofer J. Hagglund
  • Julian F. Thayer
  • Matthew J. McIntosh
  • John E. Hewett
  • Jane C. Johnson
Literature Review and Meta-Analysis


Objective: To evaluate and compare the efficacy of pharmacological and nonpharmacological treatments of fibromyalgia syndrome (FMS). Methods: This meta-analysis of 49 fibromyalgia treatment outcome studies assessed the efficacy of pharmacological and nonpharmacological treatment across four types of outcome measures—physical status, self-report of FMS symptoms, psychological status, and daily functioning. Results: After controlling for study design, antidepressants resulted in improvements on physical status and self-report of FMS symptoms. All nonpharmacological treatments were associated with significant improvements in all four categories of outcome measures with the exception that physically-based treatment (primarily exercise) did not significantly improve daily functioning. When compared, nonpharmacological treatment appears to be more efficacious in improving self-report of FMS symptoms than pharmacological treatment alone. A similar trend was suggested for functional measures. Conclusion: The optimal intervention for FMS would include nonpharmacological treatments, specifically exercise and cognitive-behavioral therapy, in addition to appropriate medication management as needed for sleep and pain symptoms.


Fibromyalgia Amitriptyline Zolpidem Scandinavian Journal Fibromyalgia Syndrome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© The Society of Behavioral Medicine 1999

Authors and Affiliations

  • Lynn A. Rossy
    • 1
  • Susan P. Buckelew
    • 1
  • Nancy Dorr
    • 2
  • Kristofer J. Hagglund
    • 1
  • Julian F. Thayer
    • 1
  • Matthew J. McIntosh
    • 1
  • John E. Hewett
    • 1
  • Jane C. Johnson
    • 1
  1. 1.Department of PsychologyUniversity of MissouriColumbiaUSA
  2. 2.Jamestown CollegeJamestownUSA

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