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Chinese Science Bulletin

, Volume 46, Issue 14, pp 1186–1190 | Cite as

Icariin on relaxation effect of corpus cavernosum smooth muscle

  • Zhongcheng Xin
  • Kim Euikyung
  • Zhenji Tian
  • Guiting Lin
  • Yinglu Guo
Notes

Abstract

NO-cGMP pathway in penile corpus cavernosal smooth muscle plays an important role in penile erection. The level of cGMP is regulated by a balance between the rate of synthesis by guanylate cyclase and the rate of hydrolytic breakdown to guanosine 5′ monophosphate (GMP) by phosphodiesterase 5(PDE5). Icariin is isolated from natural drug Epimedii herba, it is shown to have the relaxation effect on corpus cavernosal smooth muscle of rabbit (IC50: 4×10−4 mol/L), and the mechanism of the relaxation effect of Icariin on corpus cavernosum believed to have the inhibiting effect on PDE5 and activation of NO-cGMP pathway to enhancing penile erection.

Keywords

Icariin corpus cavernosm cGMP erection 

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Copyright information

© Science in China Press 2001

Authors and Affiliations

  • Zhongcheng Xin
    • 1
  • Kim Euikyung
    • 2
  • Zhenji Tian
    • 1
  • Guiting Lin
    • 1
  • Yinglu Guo
    • 1
  1. 1.Department of Urology, The First HospitalPeking UniversityBeijingChina
  2. 2.Department of Life SciencePohang University of Science and TechnologyPohangKorea

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