Hippocampal volume asymmetry and age at illness onset in males with schizophrenia

  • Hiroshi Fukuzako
  • Koichiro Yamada
  • Satoshi Kodama
  • Tomohiko Yonezawa
  • Tsuyoshi Fukuzako
  • Kaoru Takenouchi
  • Yoshiki Kajiya
  • Masayuki Nakajo
  • Morikuni Takigawa
Original Paper

Abstract

To determine whether there are disturbances of hippocampal volume asymmetry in schizophrenic patients, we obtained contiguous, I-mm-thick magnetic resonance images in 28 males with chronic schizophrenia and in 28 age-matched healthy males. The schizophrenic patients showed a bilateral reduction in volume of the hippocampal formation (HF; left 7.0%; right 8.7%). This reduction was significantly associated with the severity of disorganization syndrome (P < 0.0005). A significant asymmetry in the HF volume was found in the control subjects (P = 0.006), but not in the patients (P = 0.40). There was a significant positive correlation between the asymmetry index and the patient’s age at the onset of schizophrenia (r = 0.46,P = 0.01). Results indicate that a disturbance in the normal asymmetry of the HF may be a characteristic in schizophrenia, particularly in patients with an early onset of the illness.

Key words

Hippocampal formation Asymmetry Magnetic resonance imaging Onset Schizophrenia 

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Copyright information

© Springer-Verlag 1997

Authors and Affiliations

  • Hiroshi Fukuzako
    • 1
  • Koichiro Yamada
    • 1
  • Satoshi Kodama
    • 1
  • Tomohiko Yonezawa
    • 1
  • Tsuyoshi Fukuzako
    • 1
  • Kaoru Takenouchi
    • 1
  • Yoshiki Kajiya
    • 2
  • Masayuki Nakajo
    • 2
  • Morikuni Takigawa
    • 1
  1. 1.Departments of Neuropsychiatry and Radiology, Faculty of MedicineKagoshima UniversityKagoshimaJapan
  2. 2.Department of Radiology, Faculty of MedicineKagoshima UniversityKagoshimaJapan

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