Virchows Archiv B

, 59:137 | Cite as

Isolation of a growth and mitosis inhibitory peptide from mouse liver

  • Karl-Ludvig Reichelt
  • Jan-Erik Paulsen
  • Kjell Elgjo


The isolation of a liver peptide that inhibits the growth, mitosis rate and thymidine incorporation in regenerating liver is described. The peptide has the structure Pyroglu-gln-gly-ser-asn, and the deamidated forms are also active. The peptide probably belongs to a class of growth inhibitors with a high degree of tissue specificity. Two such peptides have previously been isolated from the epidermis (Reichelt et al. 1987) and from colonic tissue (Skraastad et al. 1987).

Key words

Liver Inhibitor Mitosis Peptide 


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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • Karl-Ludvig Reichelt
    • 1
  • Jan-Erik Paulsen
    • 1
  • Kjell Elgjo
    • 1
  1. 1.Department of Pediatric Research and Institute of Pathology, RikshospitaletThe University of OsloOslo 1Norway

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