Virchows Archiv B

, Volume 54, Issue 1, pp 152–154 | Cite as

Purification and characterization of a growth inhibitory hepatic peptide

A preliminary note
  • Jan Erik Paulsen
  • Karl L. Reichelt
  • Anne K. Petersen


A pentapeptide isolated from normal mouse liver seems to inhibit DNA synthesis (3H-thymidine incorporation into liver DNA and labelling indices) and the mitotic rate (G 2-M cell flux) in regenerating mouse liver. The inhibitor is somewhat similar to the growth inhibitory pentapeptides previously reported for granulocytes and epidermis. It is active at very low dose levels, showing a bell-shaped dose-response curve.

Key words

Liver regeneration Growth inhibitors Peptides DNA synthesis Mitotic rate 


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Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • Jan Erik Paulsen
    • 1
  • Karl L. Reichelt
    • 2
  • Anne K. Petersen
    • 1
  1. 1.Institute of PathologyOslo 1Norway
  2. 2.Pédiatric Research InstituteOslo 1Norway

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