Low fasting serum insulin in Japanese alcohol consumers does not imply improved coronary risk factors
- 19 Downloads
The effects of alcohol consumption on coronary risk factors (CRFs) and insulin resistance (IR) have seemed equivocal in previous studies. This study aimed to clarify the implications of low fasting blood insulin observed in alcohol consumers as related to CRFs and IR.
A cross-sectional observation in 2133 middle-aged healthy Japanese men for associations of increases in alcohol consumption, fasting serum insulin concentration and serum gammaglutamyltransferase (GGT) activity with the major CRFs of high systolic blood pressure (SBP), fasting serum glucose, triglycerides (TG), total- and LDL-cholesterol (tCh&LDLc) and low serum HDL-cholesterol (HDLc).
Increased alcohol consumption was related to higher SBP, serum GGT, glucose and HDLc, and lower serum LDLc and insulin. Although high serum insulin was significantly related to all of the CRFs in all nondrinkers, moderate drinkers consuming up to 59 ml of alcohol per day and excessive drinkers consuming more, the means of SBP, serum glucose and HDLc were significantly higher and serum LDLc was lower in drinkers than in nondrinkers at any level of serum insulin, indicating that the good and bad profiles of CRFs in alcohol consumers are independent of their low fasting serum insulin. High serum GGT related to increased alcohol consumption and/or body weight was significantly associated with high serum insulin and all of the CRFs in all categories of alcohol consumption.
Low fasting serum insulin observed in drinkers does not imply improved CRFs, and thus may not imply improved IR. High serum GGT may reflect increased IR in both drinkers and nondrinkers.
Key wordsalcohol consumption insulin glucose coronary risk factors insulin resistance serum gammaglutamyltransferase
Unable to display preview. Download preview PDF.
- (5).Perry IJ, Wannamethee SG, Walker MK, Thomson AG, Whincup PH, Shaper AG, Prospective study of risk factors for development of non-insulin dependent diabetes in middleaged British men. Brit J Med. 1995;310:560–564.Google Scholar
- (6).Rimm EB, Chan J, Stampfer MJ, Colditz GA, Willett WC. Prospective study of cigarette smoking, alcohol use, and the risk of diabetes in men. Brit J Med. 1995;310:555–559.Google Scholar
- (24).Razzay G, Heaton KW. Moderate alcohol consumption has been shown previously to improve insulin sensitivity in men. Brit J Med. 1997;314:443–444.Google Scholar
- (30).Mayes PA. Gluconeogenesis and control of the blood glucose. In: Murray RK, Granner DK, Mayes PA, Rodwell VW eds. Harper’s Biochemistry 25th ed. New York: McGraw-Hill, 2000;208–218.Google Scholar