The American Journal of Digestive Diseases

, Volume 19, Issue 10, pp 323–325

The effect of other Lipotropic substances on the fate of Choline after oral and intravenous administration

  • Sheldon S Waldstein
  • Frederick Steigmann

DOI: 10.1007/BF02897241

Cite this article as:
Waldstein, S.S. & Steigmann, F. Amer. Jour. Dig. Dis. (1952) 19: 323. doi:10.1007/BF02897241

Summary and Conclusions

  1. 1.

    In vitro degradation of choline to trimethylamine (TMA) by fecal bacteria is unchanged in the presence of methionine, inositol, or both.

  2. 2.

    Rats fed methionine and inositol together with choline excreted the same amount of TMA in the urine as rats fed choline alone. Human experiments duplicated the experience in animals.

  3. 3.

    Humans excrete the same amount of choline in the urine following the intravenous injection of methionine, inositol and choline together as they do following the injection of choline alone.

  4. 4.

    The intravenous injection of methionine, inositol, and choline in relatively large amounts is well tolerated and appears to be without danger.

  5. 5.

    The presence of the lipotropic agents methionine and inositol does not appear to influence the degradation or excretion of choline after oral or intravenous administration, again pointing to the differences in the lipotropic action of these substances. We wish to thank Dr. Hans Popper for this generous advice during the conduct of tliis investigation.


Copyright information

© Sandfield Publishing Company 1952

Authors and Affiliations

  • Sheldon S Waldstein
    • 1
    • 2
  • Frederick Steigmann
    • 1
    • 2
  1. 1.Hektoen Institute for Medical ResearchChicago
  2. 2.Departments of Internal Medicine and Therapeutics of the Cook County HospitalChicago

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