The American Journal of Digestive Diseases

, Volume 19, Issue 10, pp 323–325 | Cite as

The effect of other Lipotropic substances on the fate of Choline after oral and intravenous administration

  • Sheldon S Waldstein
  • Frederick Steigmann
Article
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Summary and Conclusions

  1. 1.

    In vitro degradation of choline to trimethylamine (TMA) by fecal bacteria is unchanged in the presence of methionine, inositol, or both.

     
  2. 2.

    Rats fed methionine and inositol together with choline excreted the same amount of TMA in the urine as rats fed choline alone. Human experiments duplicated the experience in animals.

     
  3. 3.

    Humans excrete the same amount of choline in the urine following the intravenous injection of methionine, inositol and choline together as they do following the injection of choline alone.

     
  4. 4.

    The intravenous injection of methionine, inositol, and choline in relatively large amounts is well tolerated and appears to be without danger.

     
  5. 5.

    The presence of the lipotropic agents methionine and inositol does not appear to influence the degradation or excretion of choline after oral or intravenous administration, again pointing to the differences in the lipotropic action of these substances. We wish to thank Dr. Hans Popper for this generous advice during the conduct of tliis investigation.

     

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References

  1. 1.
    Huerga, J.de la and Popper, H.: Urinary Excretion of Choline Metabolites Following Choline Administration in Normals and Patients with Hepatobiliary Diseases, J. Clin. Invest. 30: 468–470, (May), 1951.Google Scholar
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    Huerga, J.de la, Popper, H., and Steigmann, F.: Urinary Excretion of Choline and Trimethylamines After Intravenous Administration of Choline in Liver Diseases, J. Lab. and Clin. Med. 38: 904–910, (Dec), 1951.Google Scholar
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    Popper, H., Huerga, J. de la, and Koch-Weser, D.: Fate of Choline in Rats with and without Experimental Hepatic Injury, J. Lab. & Clin. Med. 39: 725 (May), 1952.Google Scholar
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    Perlman, I., and Chaikoff, I. L.: Radioactive Phosphorus as an Indicator of Phospholipid Metabolism. V. On the Mechanism of the Action of Choline Upon the Liver of the Fat-Fed Rat, J. Biol. Chem. 127: 211–220(Jan.), 1939.Google Scholar
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    du Vigneaud, V., Chandler, J. P., Moyer, A. W., and Keppel, D. M.: The Effect of Choline on the Ability of Homocystine to Replace Methionine in the Diet, J. Biol. Chem. 131: 57–76 (Nov.), 1939.Google Scholar
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    MacFarland, M. L. and McHenry, E. W.: Further Observations on the Lipotropic Need for Inositol, J. Biol. Chem. 176: 429–434, (Oct.), 1948.Google Scholar
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    Peterson, W. H. and Peterson, M. S.: Relation of Bacteria to Vitamins and Other Growth Factors, Bact. Rev. 9: 49–109 (June), 1945.PubMedGoogle Scholar

Copyright information

© Sandfield Publishing Company 1952

Authors and Affiliations

  • Sheldon S Waldstein
    • 1
    • 2
  • Frederick Steigmann
    • 1
    • 2
  1. 1.Hektoen Institute for Medical ResearchChicago
  2. 2.Departments of Internal Medicine and Therapeutics of the Cook County HospitalChicago

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