Cancer Chemotherapy and Pharmacology

, Volume 26, Issue 3, pp 223–226 | Cite as

Evaluation of continuous-infusion alpha-difluoromethylornithine therapy for colorectal carcinoma

  • Jaffer A. Ajani
  • David M. Ota
  • V. Bruce Grossie
  • James L. Abbruzzese
  • Jack S. Faintuch
  • Yehuda Z. Patt
  • Diane E. Jackson
  • Bernard Levin
  • Kenji Nishioka


A total of 32 evaluable patients with measurable advanced colorectal carcinoma were treated with continuous-infusion alpha-difluoromethylomithine (DFMO) at a median daily dose of 8 g/m2 (range, 6–14 g/m2). DFMO was infused over 24 h daily for 28 days, followed by a rest period of 7 days. Of the 32 patients, 14 had received no prior chemotherapy. A total of 65 courses was given, with the median being 2 (range, 1–9 courses). None of the patients achieved a partial or complete response; however, 3 patients achieved a minor response and 14 had stable disease. The frequent toxic effects of DFMO included thrombocytopenia (which was dose-limiting), malaise, nausea, vomiting, reversible hearing loss, and diarrhea. Our data suggest that continuous-infusion DFMO therapy is feasible and results in only mild gastrointestinal toxicity. Although DFMO proved to be ineffective as a single agent in this trial, it could probably best be used in combination with cytotoxic agents known to enhance its antitumor activity in a preclinical setting.


Polyamine Metabolism Polyamine Synthesis Carcino Embryonic Antigen Level Median Daily Dose Advanced Colorectal Carcinoma 
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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • Jaffer A. Ajani
    • 2
  • David M. Ota
    • 1
  • V. Bruce Grossie
    • 1
  • James L. Abbruzzese
    • 2
  • Jack S. Faintuch
    • 2
  • Yehuda Z. Patt
    • 2
  • Diane E. Jackson
    • 2
  • Bernard Levin
    • 2
  • Kenji Nishioka
    • 1
  1. 1.Departments of General SurgeryThe University of Texas M. D. Anderson Cancer CenterHoustonUSA
  2. 2.Department of Medical OncologyM. D. Anderson Cancer CenterHoustonUSA

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