Pro-oxidant and anti-oxidant status in patients of sickle cell anaemia

  • Jyoti Titus
  • Suresh Chari
  • Madhur Gupta
  • Nitin Parekh

Abstract

The role of oxidant damage to red cells in sickle cell anaemia has been of interest in recent years. Although, available reports suggest that sickle cell erythrocytes are susceptible to endogenous free radical mediated oxidant damage there remains discrepancy in the status of antioxidant enzymes and antioxidant vitamins in these patients. In view of this, 107 cases of sickle cell anaemia (36 ‘SS’ and 71 ‘AS’ pattern—as confirmed by haemoglobin electrophoresis) were subjected to analysis of malondialdehyde, ascorbic acid, superoxide dismutase and albumin. The results were compared with 54 age and sex matched healthy controls. The results indicate a marked increase in lipid peroxidation and superoxide dismutase levels in both ‘SS’ and ‘AS’ types of sickle cell anaemia as compared to controls. Although no difference was observed in the levels of albumin in these groups the levels of ascorbic acid were significantly depleted in sickle cell anaemia patients. The results are indicative of enhanced lipid peroxidation along with imbalance in the pro-oxidant and antioxidant status in patients of sickle cell anaemia.

Key Words

Pro-oxidant antioxidant enzymes antioxidant vitamins sickle cell anaemia 

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Copyright information

© Association of Clinical Biochemists of India 2004

Authors and Affiliations

  • Jyoti Titus
    • 1
  • Suresh Chari
    • 1
  • Madhur Gupta
    • 1
  • Nitin Parekh
    • 2
  1. 1.Department of BiochemistryIndira Gandhi Medical CollegeNagpur
  2. 2.Department of PhysiologyIndira Gandhi Medical CollegeNagpur

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