Pathology & Oncology Research

, Volume 11, Issue 4, pp 236–241 | Cite as

Diagnostic value of tumor markers for differentiating malignant and benign pleural effusions of Iranian patients

  • Sied Mohammad Ali Ghayumi
  • Samrad Mehrabi
  • Mehrnossh Doroudchi
  • Abbas Ghaderi
Article

Abstract

In order to evaluate the diagnostic yield of tumor markers in differentiating malignant and benign pleural effusions, we carried out a prospective study in a group of Iranian people. Pleural and serum levels of carcinoembryonic antigen (CEA), carbohydrate antigen 15-3 (CA15-3), neuron-specific enolase (NSE) and cancer antigen 125 (CA 125) were assayed prospectively in patients with pleural effusion (40 malignant and 37 benign). The highest sensitivity was obtained with a combination of CA 15-3 in serum, and CA 15-3 and CEA in pleural fluid (80%), also with combination of CA 15-3 in serum, and CA 15-3, NSE and CEA in pleural fluid (80%). The highest specificity was obtained with combination of CA 15-3 in serum, and CA 15-3 and NSE in pleural fluid (100%), and also with combination of CA 15-3 in serum, and CA 15-3, NSE and CEA in pleural fluid (100%).

Key words

pleural effusion tumor markers 

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Copyright information

© Arányi Lajos Foundation 2005

Authors and Affiliations

  • Sied Mohammad Ali Ghayumi
    • 1
  • Samrad Mehrabi
    • 1
  • Mehrnossh Doroudchi
    • 2
  • Abbas Ghaderi
    • 2
    • 3
  1. 1.Department of Internal MedicineShiraz University of Medical SciencesShirazIran
  2. 2.Departments of ImmunologyShiraz University of Medical SciencesShirazIran
  3. 3.Shiraz Institute for Cancer ResearchShiraz University of Medical SciencesShirazIran

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