Bcl-2 and MALT1 genes are not involved in the oncogenesis of uterine tumors resembling ovarian sex cord tumors

  • Sanda ŠitićEmail author
  • Petra Korać
  • Petra Peharec
  • Gojko Zovko
  • Marija Milković Periša
  • Slavko Gašparov
Case Report


Uterine tumors resembling ovarian sex cord tumors (UTROSCT) are rare entities. They were described by Clement and Scully in 1976 who classified them into groups I and II. Group I comprises typical endometrial stromal neoplasms with focal areas resembling ovarian sex cord elements and group II are predominantly or completely composed of ovarian sex cord-like elements. We report a case of UTROSCT type II with cytogenetic analysis. The tumor occurred in a 76-year-old woman who presented with vaginal bleeding. The tumor was lobulated, firm, yellow and histologically composed of sex cord-like elements. Tumor cells expressed vimentin, CD10, CD99 and alpha-actin. Cytogenetic analysis in a previously reported case detected translocation t(4;18)(q21.1;q21.3) in the majority of cells. Bcl-2 and MALT1 genes are located at or near the translocation breakpoints, and the aim of this study was to determine whether these genes were involved in chromosomal translocation or tumorigenesis. We did not find IgH translocation or the most common MALT translocations. Bcl-2 was also not involved in this oncogenesis.

Key words

uterus ovarian sex cord tumors Bcl-2 MALT1 translocation 


  1. 1.
    Baker RJ, Hildebrandt RH, Rouse RV, Hendrickson MR, Longacre TA: Inhibin and CD99 (MIC2) expression in uterine stro mal neoplasms with sex-cord-like elements. Hum Pathol 30: 671–679, 1999PubMedCrossRefGoogle Scholar
  2. 2.
    Busam KJ, Iversen K, Coplan KA, Old LJ, Stocken E, Chen YT, McGregor D, Jungbluth A: Immunoreactivity for A103, an antibody to melanocytic antigen melan-A (Mart-1), in adrenocortical and other steroid tumors. Am J Surg Pathol 22: 57–63, 1998PubMedCrossRefGoogle Scholar
  3. 3.
    Clement PB, Scully RE: Uterine tumors resembling ovarian sex-cord tumors. Am J Clin Pathol 66: 512–525, 1976PubMedGoogle Scholar
  4. 4.
    Fukunaga M, Miayazawa Y, Ushigome S: Endometrial lowgrade stromal sarcoma with ovarian sex cord-like differentiation: report of two cases with an immunohistochemical and flow cytometric study. Pathol Int 47: 412–415, 1977Google Scholar
  5. 5.
    Harris NL, Jaffe ES, Diebold J, Flandrin G, Muller-Hermelink HK, Vardiman J: The World Health Organisation classification of neoplastic diseases of the haematopoetic and lymphoid tissue: report of the Clinical Advisory Committee Meeting, Airlie House, Virginia, November 1997. Histopathology 36: 69–97, 2000PubMedCrossRefGoogle Scholar
  6. 6.
    Hauptmann S, Nadjari B, Kraus J, Turnwald W, Dietel M: Uterine tumor resembling ovarian sex-cord tumor—a case report and review of the literature. Virchows Arch 439: 97–101, 2001PubMedCrossRefGoogle Scholar
  7. 7.
    Hedley DW, Friedlander ML, Taylor IW, Rugg CA, Musgrove EA: Method for analysis of cellular DNA content of paraffinembedded pathological material using flow cytometry. J Histochem Cytochem 31: 1333–1335, 1983PubMedGoogle Scholar
  8. 8.
    Hiddemann W, Schumann J, Andreeff M, Barlogie B, Herman CJ, Leif RC, Mayall BH, Murphy RF, Sandberg AA: Convention on nomenclature for DNA cytometry. Cytometry 5: 445–446, 1984CrossRefGoogle Scholar
  9. 9.
    Hillard JB, Malpica A, Ramirez PT: Conservative management of a uterine tumor resembling an ovarian sex cord-stromal tumor. Gynecol Oncol 92: 347–352, 2004PubMedCrossRefGoogle Scholar
  10. 10.
    Horn LC, Stegner HE: Uteriner Stromatumor mit ovarieller Keimstrangdifferenzierung. Pathologe 16: 421–425, 1995PubMedCrossRefGoogle Scholar
  11. 11.
    Isaacson PG: Update on MALT lymphomas. Best Pract Res Clin Haematol 18: 57–68, 2005PubMedCrossRefGoogle Scholar
  12. 12.
    Rabbani W, Deavers MT, Malpica A, Burke TW, Liu J, Ordonez NG, Jhingran A, Silva EG: Uterine tumor resembling ovarian sex-cord tumor: report of a case mimicking cervical adenocarcinoma. Int J Gynecol Pathol 22: 297–302, 2003CrossRefGoogle Scholar
  13. 13.
    Kantelip B, Cloup N, Dechelotte P: Uterine tumor resembling ovarian sex cord tumors: Report of a case with ultrastructural study. Hum Pathol 17: 91–94, 1986PubMedCrossRefGoogle Scholar
  14. 14.
    Krishnamurthy S, Jungbluth AA, Busam KJ, Rosai J: Uterine tumors resembling ovarian sex-cord tumors have an immunophenotype consistent with true sex-cord differentiation. Am J Surg Pathol 22: 1078–1082, 1998PubMedCrossRefGoogle Scholar
  15. 15.
    Mazur MT, Kraus FT: Histogenesis of morphologic variations in tumors of the uterine wall. Am J Surg Pathol 4: 59–74, 1980PubMedCrossRefGoogle Scholar
  16. 16.
    Suzuki C, Matsumoto T, Fukunaga M, Itoga T, Furugen Y, Kurosaki Y, Suda K, Kinoshita K: Uterine tumors resembling ovarian sex-cord tumors producing parathyroid hormonerelated protein of the uterine cervix. Pathol Int 52: 164–168, 2002PubMedCrossRefGoogle Scholar
  17. 17.
    Wang J, Blakey GL, Zhang L, Bane B, Torbenson M, Li S: Uterine tumor resembling ovarian sex cord tumor: report of a case with t(X;6)(p22.3;q23.1) and t(4;18)(q21.1;q21.3). Diagn Mol Pathol 12: 174–180, 2003PubMedGoogle Scholar

Copyright information

© Arányi Lajos Foundation 2007

Authors and Affiliations

  • Sanda Šitić
    • 1
    Email author
  • Petra Korać
    • 1
  • Petra Peharec
    • 2
  • Gojko Zovko
    • 3
  • Marija Milković Periša
    • 1
  • Slavko Gašparov
    • 1
  1. 1.Department of Clinical Pathology and CytologyClinical Hospital MerkurCroatia
  2. 2.Department of Clinical PathologyClinical Hospital CentreCroatia
  3. 3.Department of Gynecological Oncology, Clinical Hospital MerkurUniversity Clinic for Gynecology and ObstetricsZagrebCroatia

Personalised recommendations