Pathology & Oncology Research

, Volume 12, Issue 2, pp 83–86

Prevalence of hormone receptors and HER2/neu in breast cancer cases in Jordan

  • Maher A. Sughayer
  • Maha M. Al-Khawaja
  • Suleiman Massarweh
  • Mahmoud Al-Masri
Article

Abstract

The management and prognosis of breast cancer nowadays require the evaluation of Estrogen (ER), Progesterone Receptors (PR) and HER2/neu. Ethnic variation in the expression of these receptors is well documented. The aim of this study is to determine the prevalence of ER, PR and HER2/neu among Jordanian women with breast cancer of ductal and lobular types. A retrospective analysis was performed on 267 cases of breast cancer referred for treatment at King Hussein Cancer Center, Jordan between the period of June 2003 and June 2004. Standard immune stains were used for evaluation of hormone receptors and HER2/neu. In addition, evaluation of HER2/neu was done by FISH in selected cases. Of these 267 cases, 240 (89.9%) were ductal carcinomas of various histological grades, 122 (50.8%) of which were ER-positive, 138 (57.5%) PR-positive and 42 (17.5%) HER2/neu-positive. Twentytwo (8.2%) of all cases were lobular carcinomas, 15 (68%) of which were ER-positive,20 (90.9%) PR-positive and 3 (13.6%) HER2/neu-positive. Five (1.9%) of the total cases were of mixed lobular and ductal types, 4 (80%) of which were ER-positive, 3 (60%) PR-positive and none were positive for HER2/neu. The prevalence of hormone receptor positivity in breast cancer of Jordanian women is lower than that of the western populations and close to other populations such as the Chinese and the minor ethnic groups of Northern America (African Americans).(Pathology Oncology Research Vol 12, No 2, 83–86)

Key words

breast cancer hormone receptors HER2/neu 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Arányi Lajos Foundation 2006

Authors and Affiliations

  • Maher A. Sughayer
    • 1
  • Maha M. Al-Khawaja
    • 1
  • Suleiman Massarweh
    • 2
  • Mahmoud Al-Masri
    • 3
  1. 1.Department of PathologyKing Hussein Cancer CenterAmmanJordan
  2. 2.Department of Medical OncologyKing Hussein Cancer CenterAmmanJordan
  3. 3.Department of Surgical OncologyKing Hussein Cancer CenterAmmanJordan

Personalised recommendations