Nodular paragranuloma and progressively transformed germinal centers
- 21 Downloads
- 60 Citations
Summary
Ultrastructural and immunohistologic findings in a nodular variant of Hodgkin’s disease with lymphocytic predominance, called nodular paragranuloma, are presented and compared with those in so-called progressively transformed germinal centers. These are large follicles with numerous lymphocytes which can be found not only in nonspecific lymphadenitis, but also in lymph nodes from patients with nodular paragranuloma.
The immunoperoxidase technique was applied on paraffin sections to detect intracytoplasmic immunoglobulin and lysozyme. The so-called L & H type Sternberg-Reed cells contained IgG and one type of light chain per cell, suggesting that such cells produce immunoglobulin. The ultrastructure of the L & H type Sternberg-Reed cells favored the immunoblastic nature of these cells.
It is concluded that nodular paragranuloma differs from other types of Hodgkin’s disease by its localization in B-cell areas and the presence of atypical B immunoblasts.
Key words
Hodgkin’s disease Nodular paragranuloma Germinal centers Ultrastructure ImmunohistologyPreview
Unable to display preview. Download preview PDF.
References
- Graham, R.C., Jr., Karnovsky, M.J.: The early stages of absorption of injected horseradish peroxidase in the proximal tubules of mouse kidney: Ultrastructural cytochemistry by a new technique. J. Histochem. Cytochem.14, 291–302 (1966)PubMedGoogle Scholar
- Jackson, H., Jr., Parker, F., Jr.: Hodgkin’s disease and allied disorders. New York: Oxford University Press 1947Google Scholar
- Lennert, K., Kaiserling, E., Müller-Hermelink, H.K.: Malignant lymphomas: Models of differentiation and cooperation of lymphoreticular cells. In: Clkson, B. Marks, P.A, Till, J.E. (Eds.): Differentiation of normal and neoplastic hematopoietic cells, BookB, Sect. 8, pp. 897–913. Cold Spring Harbor Conferences on Cell Proliferation, Vol. 5. Cold Spring Harbor: Cold Spring Harbor Laboratory 1978Google Scholar
- Lennert, K., Mohri, N.: Histologische Klassifizierung und Vorkommen des M. Hodgkin. Internist15, 57–65 (1974)Google Scholar
- Lennert, K., Müller-Hermelink, H.K.: phocyten und ihre Funktionsformen-Morphologie, Organisation und immunologische Bedeutung. Verh. Anat. Ges. (Jena)69, 19–62 (1975)Google Scholar
- Lukes, R.J., Butler, J.J.: The pathology and nomenclature of Hodgkin’s disease. Cancer Res.26, 1063–1081 (1966)PubMedGoogle Scholar
- Nakane, P.K.: Simultaneous localization of multiple tissue antigens using the peroxidase-labeled antibody method: A study on pituitary glands of the rat. J. Histochem. Cytochem.16, 557–560 (1968)PubMedGoogle Scholar
- Papadimitriou, C.S., Stein, H., Lennert, K.: The complexity of immunohistochemical staining pattern of Hodgkin and Sternberg-Reed cells-Demonstration of immunoglobulin, albumin, α1-antichymotrypsin and lyozyme. Int. J. Cancer21, 531–541 (1978)PubMedCrossRefGoogle Scholar
- Poppema, S., Elema, J.D., Halie, M.R.: The significance of intra-cytoplasmic proteins in Reed-Sternberg cells. Cancer42, 1793–1803 (1978)PubMedCrossRefGoogle Scholar
- Poppema, S., Elema, J.D., Halie, M.R.: The localization of Hodgkin’s disease in lymph nodes. A study with immunohistological, enzyme histochemical and rosetting techniques on frozen sections. Int. J. Cancer (1979a, in press)Google Scholar
- Poppema, S., Kaiserling, E., Lennert, K.: Hodgkin’s disease with lymphocytic predominance, nodular type (nodular paragranuloma) and progressively transformed germinal centres. — A cytohistological study. Histopathology3, 295–308 (1976)CrossRefGoogle Scholar
- Poppema, S., Kaiserling, E., Lennert, K.: Epidemiology of nodular paragranuloma (Hodgkin’s disease with lymphocytic predominance, nodular). Cancer Res. Clin. Oncol. (1979 c, in press)Google Scholar
- Rappaport, H., Winter, W.J., Hicks, E.B.: Follicular lymphoma. A re-evaluation of its position in the scheme of malignant lymphoma, based on a survey of 253 cases. Cancer (Philad.)9, 792–821 (1956)CrossRefGoogle Scholar
- Sternberger, L.A., Hardy, P.H., Jr., Cuculis, J.J., Meyer, H.G.: The unlabeled antibody enzyme method of immunohistochemistry. Preparation and properties of soluble antigen-antibody complex (horseradish peroxidase-antihorseradish peroxidase) and its use in identification of spirochetes. J. Histochem. Cytochem.18, 315–333 (1970)PubMedGoogle Scholar
- Taylor, C.R.: The nature of Reed-Sternberg cells and other malignant “reticulum” cells. Lancet 1974, II, 802–807CrossRefGoogle Scholar