Biologia Plantarum

, Volume 21, Issue 1, pp 15–21 | Cite as

Mitodepressive effects ofChelidonium alkaloids on root tip cells ofAllium cepa L

  • Anna Krahulcová
Original Papers


A comparison of the effects of a water extract of the fresh vegetation apex ofChelidonium majus L. var.majus, with those of berberine sulphate and of chelidonine hydrochloride is reported. The water extract of fresh stems and leaves ofChelidonium majus and the berberine sulphate solution had marked mitodepressive effects on onion root tip cells. Chelidonine hydrochloride had similar but less marked effects. On the basis of the results obtained it can be assumed that the most active group of substances with cytostatic effects, hindering the cells from entering mitosis, are protoberberine bases contained in the latex ofChelidonium majus. Within the range of the investigated concentrations the extract of fresh stems and leaves was less toxic for the cells than berberine sulphate. The data ascertained provide evidence that the mechanism of the cytostatic action of chelidonine, of berberine, as well as of the extract of fresh stems and leaves ofChelidonium, majus differs from the mechanism of the action of colchicine. Of the testedChelidonium alkaloids only chelidonine produced a partial inactivation of the mitotic spindle.


Alkaloid Mitotic Index Berberine Mitotic Spindle Sanguinarine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Academia 1979

Authors and Affiliations

  • Anna Krahulcová
    • 1
  1. 1.Research Institute of Child Development, Faculty of PediatricsCharles UniversityPraha 5Czechoslovakia

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