Chinese Science Bulletin

, Volume 44, Issue 14, pp 1257–1264 | Cite as

Development in the research of molecular mechanism of Alzheimer’s disease

  • Ming Gu
  • Xiaomin Wang
  • Yuanyue Mu
  • Ming Fan
Reviews

Abstract

Alzheimer’s disease (AD) is a kind of central nervous system disease. The cause of AD is unclear. It is found that the remarkable histopathological characters of AD are senile plaques and neurofibrillary tangles. β-amyloid plays an important role in the formation of senile plaques and the abnormal phosphotylation of Tau protein is the main reason of neurofibrillary tangles. Apolipoprotein E is correlated to AD’ s access, and the third pathological character-AMY plaque perhaps represents a new cause of AD. Presenlin and proteinaceous infectious particles are also related with AD. A summary of molecular mechanism for AD and the development of research is presented.

Keywords

Alzheimer’ s disease senile plaque neurofibrillary tanglee β-amyloid Tau protein apoliporprotein E presenlin proteinaceous infectious particles 
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Copyright information

© Science in China Press 1999

Authors and Affiliations

  • Ming Gu
    • 1
  • Xiaomin Wang
    • 1
  • Yuanyue Mu
    • 2
  • Ming Fan
    • 2
  1. 1.Neuroscience Research Institute of Beijing Medical UniversityBeijingChina
  2. 2.Basal Medicine Institute of Military Medical AcademyBeijingChina

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