Folia Microbiologica

, Volume 14, Issue 6, pp 571–577 | Cite as

The inhibitory effect of homologous immunoglobulin G on the degradation of antigen (human serum albumin) by rabbit cathepsin D

  • J. Štefanovič
  • M. Ferenčík
Article
Received:

Abstract

The dynamic of degradation of antigen (human serum albumin) by rabbit cathepsin D was studied in the presence of homologous immunoglobulin G having antibody activity to substrate (antigen) as well as without antibody activity. Both immunoglobulins possessed an inhibitory effect on the intensity of antigen degradation, however, immunoglobulin G with antibody activity had a more pronounced effect. The studies on the kinetics of inhibition showed that we were probably dealing with a special case of inhibition of the mixed type which is known as coupling or anticompetitive inhibition.

Keywords

Human Serum Albumin DEAE Gamma Globulin Antibody Activity Potassium Aluminum 
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Copyright information

© Academia, nakladatelství Československé akademie věd 1969

Authors and Affiliations

  • J. Štefanovič
    • 1
  • M. Ferenčík
    • 1
  1. 1.Department of Microbiology and Immunology, Faculty of MedicineComenius UniversityBratislava

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