Annals of Behavioral Medicine

, Volume 19, Issue 2, pp 78–82 | Cite as

Chronic stress modulates the virus-specific immune response to latent herpes simplex virus Type 1

  • Ronald Glaser
  • Janice K. Kiecolt-Glaser


We compared 71 family caregivers of dementia sufferers and 58 control subjects on three different immune measures relevant to latent herpes simplex virus Type 1 (HSV-1) infection: neutralizing antibody titers, antibody titers to a total viral antigen, and a proliferative memory T-cell response. Caregivers had significantly higher antibody titers to the total viral antigen and a poorer HSV-1 specific T-cell response than controls, but no significant difference in neutralizing antibody titers between groups was observed. These data provide additional evidence that psychological stress can modulate a virus-specific immune response associated with caregiving.


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Copyright information

© The Society of Behavioral Medicine 1997

Authors and Affiliations

  • Ronald Glaser
    • 1
  • Janice K. Kiecolt-Glaser
    • 1
  1. 1.Institute for Behavioral Medicine ResearchThe Ohio State University College of MedicineColumbus

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