Folia Microbiologica

, 28:397 | Cite as

Determination of optimum conditions for antibiotic production byStreptomyces galbus

  • A. K. Paul
  • A. K. Banerjee


The nutritional requirements and cultural conditions for optimal production of a new extracellular antifungal antibiotic byStreptomyces galbus under laboratory conditions were determined. Glycerol and glucose were found to be the best carbon sources, while as N-source nitrate was preferred. Maximum titre was reached after 7 d of incubation at 30 °C at pH 6.8. The metal ions Cu2+, Zn2+, Mn2+ and Fe2+ had some promoting effect. Casein hydrolysate improved production, but yeast extract markedly inhibited. Growth in shake flasks favoured higher yield of the antibiotic in a shorter time.


Streptomyces Casein Hydrolysate Antibiotic Production Organic Nitrogen Source Antifungal Antibiotic 
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Copyright information

© Institute of Microbiology, Academy of Sciences of the Czech Republic 1983

Authors and Affiliations

  • A. K. Paul
    • 1
  • A. K. Banerjee
    • 1
  1. 1.Microbiology Laboratory, Department of BotanyBurdwan UniversityBurdwan 713 104, West BengalIndia

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