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Advances in Therapy

, Volume 24, Issue 5, pp 1154–1171 | Cite as

Effect of dietary supplementation with INVERSION® femme on slimming, hair loss, and skin and nail parameters in women

  • Alain Jacquet
  • Véronique CoolenEmail author
  • Jacques Vandermander
Article

Abstract

In modern society, the ideal of slim women with beautiful hair, skin, and nails is well established. The process of aging, together with an unhealthy diet and little physical exercise, often leads to deterioration of this ideal. Two open clinical trials were conducted to investigate the effect of the proprietary oral supplement INVERSION® Femme (Inversion Laboratoires, Hasselt, Belgium) on slimming in overweight women and on hair loss, as well as on skin and nail parameters. A total of 22 overweight women aged 38 to 63 y participated in the study that explored slimming activity. In the hair loss study, 30 women aged 38 to 67 y who had experienced hair loss were examined. All 52 women in both groups were further evaluated for skin (ie, wrinkles and hydration) and nail improvement. The active ingredients in INVERSION Femme, subdivided into 2 different capsules, exhibit antioxidative activity and nutritional function; in addition, they contribute to enhanced microcirculation, tonus, and thermogenesis. Weight reduction and slimming were measured after INVERSION Femme was taken for 28 and 58 d. All women showed significant reductions in weight, body fat, and thigh circumference. During the second month of treatment, subjects showed an average 50% reduction in hair loss. INVERSION Femme is a potent “all-in-one” antiaging dietary supplement that causes significant slimming and reduction in hair loss, as well as visible improvement in skin and nail structure.

Keywords

dietary supplement weight reduction slimming hair loss aging nails wrinkles skin hydration 

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References

  1. 1.
    Segger D, Schönlau F. Supplementation with Evelle improves skin smoothness and elasticity in a double-blind, placebo-controlled study with 62 women.J Dermatolog Treat. 2004;15:222–226.PubMedCrossRefGoogle Scholar
  2. 2.
    Jacquet A. Evaluation des amincissants: une méthode très simple.Parfums Cosmétiques Arômes. 1992;108:56–58.Google Scholar
  3. 3.
    Kurban RS, Bhawan J. Histologic changes in skin associated with aging.J Dermatol Surg Oncol. 1990;16:908–914.PubMedGoogle Scholar
  4. 4.
    Dulloo AG. A role for suppressed skeletal muscle thermogenesis in pathways from weight fluctuations to the insulin resistance syndrome.Acta Physiol Scand. 2005;184:295–307.PubMedCrossRefGoogle Scholar
  5. 5.
    Shixian Q, VanCrey B, Shi J, Kakuda Y, Jiang Y. Green tea extract thermogenesis-induced weight loss by epigallocatechin gallate inhibition of catechol-O-methyltransferase.J Med Food. 2006;9: 451–458.PubMedCrossRefGoogle Scholar
  6. 6.
    Bureau JP, Ginouves P, Guilbaud J, Roux ME. Essential oils and low-intensity electromagnetic pulses in the treatment of androgen-dependent alopecia.Adv Ther. 2003;20:220–229.PubMedCrossRefGoogle Scholar
  7. 7.
    Trost LB, Bergfeld WF, Calogeras E. The diagnosis and treatment of iron deficiency and its potential relationship to hair loss.J Am Acad Dermatol. 2006;54:824–844.PubMedCrossRefGoogle Scholar
  8. 8.
    Rushton DH. Nutritional factors and hair loss.Clin Exp Dermatol. 2002;27:396–404.PubMedCrossRefGoogle Scholar
  9. 9.
    Floersheim GL. Treatment of brittle fingernails with biotin [in German].Z Hautkr. 1989;64:41–48.PubMedGoogle Scholar
  10. 10.
    Hochman LG, Scher RK, Meyerson MS. Brittle nails: response to daily biotin supplementation.Cutis. 1993;51:303–305.PubMedGoogle Scholar
  11. 11.
    Colombo VE, Gerber F, Bronhofer M, Floersheim GL. Treatment of brittle fingernails and onychoschizia with biotin: scanning electron microscopy.J Am Acad Dermatol. 1990;23:1127–1132.PubMedCrossRefGoogle Scholar
  12. 12.
    Arredondo M, Martinez R, Nunez MT, Ruz M, Olivares M. Inhibition of iron and copper uptake by iron, copper and zinc.Biol Res. 2006;39:95–102.PubMedCrossRefGoogle Scholar
  13. 13.
    Rehman A, Collis CS, Yang M, et al. The effects of iron and vitamin C co-supplementation on oxidative damage to DNA in healthy volunteers.Biochem Biophys Res Commun. 1998;246:293–298.PubMedCrossRefGoogle Scholar
  14. 14.
    Lachili B, Hininger I, Faure H, et al. Increased lipid peroxidation in pregnant women after iron and vitamin C supplementation.Biol Trace Elem Res. 2001;83:103–110.PubMedCrossRefGoogle Scholar
  15. 15.
    Kang SA, Jang YJ, Park H. In vivo dual effects of vitamin C on paraquat-induced lung damage: dependence on released metals from the damaged tissue.Free Radic Res. 1998;28:93–107.PubMedCrossRefGoogle Scholar
  16. 16.
    Frei B, Higdon JV. Antioxidant activity of tea polyphenols in vivo: evidence from animal studies.J Nutr. 2003;133:3275S-3284S.PubMedGoogle Scholar
  17. 17.
    Nakagawa T, Yokozawa T. Direct scavenging of nitric oxide and Superoxide by green tea.Food Chem Toxicol. 2002;40:1745–1750.PubMedCrossRefGoogle Scholar
  18. 18.
    Yang CS, Maliakal P, Meng X. Inhibition of carcinogenesis by tea.Annu Rev Pharmacol Toxicol. 2002;42:25–54.PubMedCrossRefGoogle Scholar
  19. 19.
    Chan MM, Fong D, Ho CT, Huang HI. Inhibition of inducible nitric oxide synthase gene expression and enzyme activity by epigallocatechin gallate, a natural product from green tea.Biochem Pharmacol. 1997;54:1281–1286.PubMedCrossRefGoogle Scholar
  20. 20.
    Stein JH, Keevil JG, Wiebe DA, Aeschlimann S, Folts JD. Purple grape juice improves endothelial function and reduces the susceptibility of LDL cholesterol to oxidation in patients with coronary artery disease.Circulation. 1999;100:1050–1055.PubMedGoogle Scholar
  21. 21.
    McCarty MF. cGMP may have trophic effects on beta cell function comparable to those of cAMP, implying a role for high-dose biotin in prevention/treatment of diabetes.Med Hypotheses. 2006; 66:323–328.PubMedCrossRefGoogle Scholar
  22. 22.
    Lu H, Meng X, Yang CS. Enzymology of methylation of tea catechins and inhibition of catechol-O-methyltransferase by (-)-epigallocatechin gallate.Drug Metab Dispos. 2003;31:572–579.PubMedCrossRefGoogle Scholar

Copyright information

© Health Communications Inc 2007

Authors and Affiliations

  • Alain Jacquet
    • 1
  • Véronique Coolen
    • 2
    Email author
  • Jacques Vandermander
    • 3
  1. 1.Département de Pharmacologie CliniqueUniversité Victor SegalenBordeauxFrance
  2. 2.Inversion LaboratoiresHasseltBelgium
  3. 3.VDMJ ConseilCagnes sur MerFrance

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