Cinnamonitriles in heterocycles synthesis: Reaction of α,β-unsaturated nitriles with thioglycolic acid
Original Articles
Received:
- 36 Downloads
Abstract
7H-thiazolo-[3,2-a]-pyridines as potential antimicrobial agents were prepared by reaction of α,β-unsaturated nitriles and thioglycolic acid.
Keywords
Cinnamonitriles thioglycolic acid 7H-thiazolo-[3,2-a]-pyridines bacterial activityPreview
Unable to display preview. Download preview PDF.
Literature Cited
- 1.Misra, V.S. and Husin, I.: Possible antitubercolotic compounds X. 2-Thiazolyl and 6-benzimidazolyl amidines.J. Indian Chem. Soc.,37, 710–712 (1960).Google Scholar
- 2.Youssef, K.M. and El-Meligi, S.: Novel 2-mercaptobenzothiazole derivatives, synthesis and antimicrobial activity.Egypt. Pharm. Sci.,30, 455–463 (1989).Google Scholar
- 3.Bayoumy, B.E., El-Mobayed, M. and El-Frargy, A.F.: Studies on B-lactans and thiazolidinones. part III. Synthesis and biological activity of some new selena diazolyl-azetidin-2-ones and thiazolindin-4-ones.Egypt. J. Pharm. Sci.,31, 13–18 (1990).Google Scholar
- 4.Harb, A.H., Mostafa, F.H. and Metwally, S.A.: Synthesis of some heterocycles of potential biological activity.Arch. Pharm. Res.,13, 187–191 (1990).CrossRefGoogle Scholar
- 5.Sadek, K.U., El-Maghraby, M.A., Maghraby, A.S. and ElNagdi, M.H.: Activated nitriles in heterocyclic synthesis: Synthesis of pyrimidine derivatives.Bull. Chem. Jpn.,61, 539–541 (1988).CrossRefGoogle Scholar
- 6.Abdel-Latif, F.F.: Heterocycles synthesis through reaction of nucleophiles with acrylonitriles. 7. A novel and facile one-step synthesis of 4H-thiopyrans.Bull. Chem. Soc. Jpn.,62, 3768–3770 (1989).CrossRefGoogle Scholar
- 7.Elgemeie, G.E.H., Sallam, M.M.M., Sherif, M.S. and Elnagdi, M.H.: A novel synthesis of 4H-thiopyrans: unexpected products of reaction of cyanothioacetamide with cinnamonitrile derivatives.Heterocycles,23, 12(1985).Google Scholar
Copyright information
© The Pharmaceutical Society of Korea 1991