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Evaluation of adenosine deaminase activity and lipid peroxidation levels in diabetes mellitus

  • Anjali C. Warrier
  • Narasimha Y. Rao
  • Devdutta S. Kulpati
  • Tarun K. Mishra
  • Bhaskar C. Kabi
Diabetes Mellitus

Abstract

There was increase in erythrocyte lipid peroxidation and adenosine deaminase (ADA) activity in red blood cells (RBC's), white blood cells (WBC's) and plasma, in 30 patients of confirmed diabetes mellitus, 10 each of insulin dependent diabetes mellitus (IDDM or type I), non-insulin dependent diabetes mellitus (NIDDM or type II) and diabetes with ketoacidosis when compared with 20 healthy individuals (controls). Glycosylated hemoglobin A1c%, plasma free fatty acid (FFA) and glycerol levels were also elevated in all the cases when compared with controls. The increase was more in diabetic ketoacidosis group. Significant positive correlations were seen between erythrocyte lipid peroxidation and ADA activities in RBC's, WBC's and plasma. It is suggested that decreased tissue adenosine levels due to increase in ADA activity, is related to the severity of hyperglycemia and lipid peroxidation in diabetes mellitus.

Key words

Adenosine deaminase Adenosine Lipid peroxidation Hyperglycemia Diabetes mellitus 

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Copyright information

© Association of Clinical Biochemists of India 1995

Authors and Affiliations

  • Anjali C. Warrier
    • 1
    • 2
  • Narasimha Y. Rao
    • 1
    • 2
  • Devdutta S. Kulpati
    • 1
    • 2
  • Tarun K. Mishra
    • 1
    • 2
  • Bhaskar C. Kabi
    • 1
    • 2
  1. 1.Department of BiochemistryMaulana Azad Medical College and Associated Lok Nayak Jai Prakash Narayan HospitalNew Delhi
  2. 2.Department of MedicineMaulana Azad Medical College and Associated Lok Nayak Jai Prakash Narayan HospitalNew Delhi

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