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Effect ofCrataeva nurvala bark decoction on enzymatic changes in liver of normal and stone forming rats

  • R. Baskar
  • N. Saravanan
  • P. Varalakshmi
Urolithiasis

Abstract

The influence of Crataeva nurvala bark decoction was studied in calcium oxalate stone forming rats, in relation to oxalate metabolism in liver. The activities of the major oxalate synthesizing enzymes in liver namely, glycollate oxidase (GAO) and lactate dehydrogenase (LDH) were significantly increased in the calculogenic group. Bark decoction treatment lowered the liver GAO activity considerably. Transport ATPases (Na+, K+ and Ca2+-ATPases) and alkaline phosphatase were enhanced in rats fed calculi producing diet, while the activities of acid phosphatase, inorganic pyrophosphatase and aminotransferases were slightly reduced. Bark decoction administration produced a marginal decrease in Na+, K+-ATPase and increase in aspartate aminotransferase activities, without significantly altering other enzyme activities. The decrease in liver GAO activity seen during bark decoction treatment, with concomitant decrease in kidney oxalate level, may prove beneficial as a prophylactic measure in preventing stone recurrence.

Key Words

Calcium oxalate stones Crataeva nurvala oxalate metabolism liver enzymes 

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Copyright information

© Association of Clinical BIochemists of India 1995

Authors and Affiliations

  • R. Baskar
    • 1
  • N. Saravanan
    • 1
  • P. Varalakshmi
    • 1
  1. 1.Department of Medical Biochemistry, Dr. A.L.M. Post Graduate Institute of Basic Medical SciencesUniversity of MadrasMadrasIndia

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