Indian Journal of Clinical Biochemistry

, Volume 10, Issue 2, pp 57–61 | Cite as

Glycosylated proteins and serum lipid profile in complicated and uncomplicated NIDDM patients

  • Bhalla Kapil
  • Shukla Rimi
  • Gupta V. P. 
  • Pugazhenthi S. 
  • Prabhu K. M. 
Diabetes Mellitus
  • 12 Downloads

Abstract

In the present study, 58 diabetic patients (type II) comprising uncomplicated (27) and complicated (31) cases along with 38 healthy matched controls were investigated for glycosylated hemoglobin (HbA1), glycosylated serum proteins (GSP) and serum lipid profile viz. triacylglycerol, total cholesterol, HDL-cholesterol (HDL-C), VLDL-C, LDL-C and their ratios. HbA1 and GSP were significantly elevated in diabetic group as a whole when compared with controls (p<0.01), but comparison of mean values of complicated and uncomplicated group revealed (though higher in complicated) that the difference between two groups was not statistically significant (p>0.05). Follow-up studies showed that while GSP levels reflect variations in blood glucose over a shorter period of 15 days, those of HbA1 do so for about 3 months. HbA1 correlated with fasting blood glucose (p<0.01), whereas GSP showed correlation with both fasting (p<0.01) and postprandial (p<0.05) blood glucose. Hypercholesterolemia and hypertriacylglycerolemia were observed (p<0.01) in both the groups. However no significant change was seen in HDL-C (p>0.05) even after accounting for sex in both the groups. Interestingly TC:HDL-C was elevated significantly (p<0.01) in the above groups. These findings seem to suggest that at the levels of hyperglycemia, hypercholesterolemia and hypertriacylglycerolemia observed, some patients are prone to develop complications earlier.

Keywords

Blood Glucose Serum Lipid Clinical Biochemistry Lipid Parameter Serum Lipid Profile 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Association of Clinical BIochemists of India 1995

Authors and Affiliations

  • Bhalla Kapil
    • 2
  • Shukla Rimi
    • 1
  • Gupta V. P. 
    • 3
  • Pugazhenthi S. 
    • 4
  • Prabhu K. M. 
    • 1
  1. 1.Department of BiochemistryUniversity College of Medical Sciences and G.T.B. Hospital, ShahdaraDelhi
  2. 2.Central Reserve Police ForceDelhi
  3. 3.Department of MedicineSafdarjung HospitalDelhi
  4. 4.Department of BiochemistryUniversity of SaskatchewanSaskatoonCanada

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