Indian Journal of Clinical Biochemistry

, Volume 17, Issue 1, pp 49–57

Potent antiulcerogenic activity of ethanol extract of leaf ofPiper betle Linn by antioxidative mechanism

  • Biswajit Majumdar
  • Susri Ray Chaudhuri
  • Arun Ray
  • Sandip K Bandyopadhyay
Article

DOI: 10.1007/BF02867942

Cite this article as:
Majumdar, B., Chaudhuri, S.R., Ray, A. et al. Indian J Clin Biochem (2002) 17: 49. doi:10.1007/BF02867942

Abstract

Pretreatment of an ethanolic extract of leaf ofPiper betle linn at a dose of 200mg/kg body weight, orally administered to rats for ten consecutive days, was found to possess a significant protective action against gastric lesions induced by indomethacin. The extract pretreatment resulted in significant increase in superoxide dismutase (SOD) and catalase (CAT) activity, increase in mucus, hexosamine and total thiol group content, but marked reduction in oxidatively damaged protein and peroxidised lipid levels as compared to untreated ulcerated control. The extract was also found to possess both superoxide and hydroxyl free radical scavenging action. The present observations establish the efficacy of the extract in prevention of experimentally induced peptic ulcer by indomethacin and antioxidant property appears to be predominantly responsible for such cytoprotective activity in the experimental model.

Key Words

Antioxidant Antiulcer Free radical scavenger Piper betle Linn 

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Copyright information

© Association of Clinical Biochemists of India 2002

Authors and Affiliations

  • Biswajit Majumdar
    • 2
  • Susri Ray Chaudhuri
    • 2
  • Arun Ray
    • 1
  • Sandip K Bandyopadhyay
    • 2
  1. 1.Department of BiochemistryCollege of Medical SciencesBharatpurNepal
  2. 2.Department of Biochemistry, Dr BC Roy Post Graduate Institute of Basic Medical Sciences, University College of MedicineCalcutta UniversityKolkata

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