Interferences in clinical chemistry analysis
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Analyses of body fluids in clinical chemistry laboratory are subject to a number of interferences that affect the analytical accuracy. The interferents arise from exogenous sources like drugs and additives as well as such endogenous sources like lipemia, hemolysis and icteria. Our studies demonstrate matrix interference in the form of analytical blas between serum and aqueous matrix calibrators. The clinical chemist should constantly be aware of this factor. Correction of interferences is recommended as an integral part of the quality assurance program.
Key wordsInterference Bichromatic analysis Matrix effects Hemolysis Quality assurance
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- 1.Narayanan, S. (1996) Pre and post analytical errors. Ind. J. Clin. Biochem. 11 (1), 7–11Google Scholar
- 2.Narayanan, S. (1996) Pre and post analytical errors in lipid determination. Ind. J. Clin. Biochem. 11 (1), 12–16.Google Scholar
- 3.Kanagasabapathy, A.S., Swaminathan, S. and Selvakumar, R. (1996). Quality control in clinical biochemistry. Ind. J. Clin. Biochem. 11 (1) 17–25.Google Scholar
- 16.Kaplan, L.A. and Pesce, A.J. (1989) Interferences in chemical analysis In: Clinical Chemistry-Theory, analysis and correlation. Eds. Kaplan L.A. and Pesce, A.J. The C.V. Mosby Company. St. Louis, USA, 2nd edn. p.808–819.Google Scholar
- 17.Fischbach, F.T. (1984) A manual of laboratory diagnostic tests. J.B. Lippincot Company, Philadelphia, 2nd edn. p. 823–847.Google Scholar