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Indian Journal of Clinical Biochemistry

, Volume 20, Issue 2, pp 195–197 | Cite as

Evaluation of serum adenosine deaminase and 5′-nucleotidase activities as probable markers in ovarian cancer

  • Pragathi P. 
  • Bharath Kumar P. V. 
  • Amar Kumar P. 
  • Ramakanth Reddy M. 
  • Sravani V. 
  • Neeraja J. 
  • Reeba Mary Eapen 
  • Gopalakrishna K. 
Article

Abstract

Adenosine deaminase (ADA) and 5′-nucleotidase (5′-NT) activities were measured in sera of patients with ovarian cancer and patients with benign ovarian tumour. The results were compared with that of a control group consisting of healthy women. ADA levels were significantly increased (P<0.001) in the ovarian cancer group (n=50) but not in the benign group (n=28) when compared to the controls (n=20). The results indicate that ADA and 5′-NT levels may help to differentiate malignant conditions from benign tumours of the ovary in addition to the existing tests such as serum CA-125 levels and histopathological study.

Key words

5′-NT ADA CA-125 Ovarian cancer 

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Copyright information

© Association of Clinical Biochemists of India 2005

Authors and Affiliations

  • Pragathi P. 
    • 1
  • Bharath Kumar P. V. 
    • 1
  • Amar Kumar P. 
    • 1
  • Ramakanth Reddy M. 
    • 1
  • Sravani V. 
    • 1
  • Neeraja J. 
    • 1
  • Reeba Mary Eapen 
    • 1
  • Gopalakrishna K. 
    • 1
  1. 1.Department of BiochemistryKasturba Medical CollegeManipal

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