Iron store and free radicals in thalassemia
Hyper-ferrous state is the result of multiple transfusions, whereby the iron excess in such conditions may be toxic to the organism. Patients suffering from thalassemia receive multiple transfusions. In the eastern part of India, both β0-thalassemia and heterozygous Eβ-thalassemia occur. This paper expresses the hyper-ferrous state, leading to iron overload in these two conditions and also reports the increased generation of free radicals, consequent to the iron overload.
Key wordsThalassemia Ferritin Malondialdehyde
Unable to display preview. Download preview PDF.
- 1.Conrad, M.E. (1998). Introduction: Iron overloading disorder and iron regulation. Seminars in Hematol. 35 (1), 1–4Google Scholar
- 3.McCord, J.M. (1992). Superoxide production and human disease. In Jesaitis, A. and Dratz, E. (eds.): Molecular basis of oxidative damage by leukocytes. Boca Raton. FL. CRC, pp. 225–239.Google Scholar
- 7.Biomond, P., Swaak, A.J. Bemdorff, C.M.et al. (1986). Superoxide dependent and independent mechanisms of iron mobilization from ferritin by xanthine oxidase implications for oxygen-free radical-induced tissue destruction during ischaemia and inflammation. Biochem. J. 239, 169–173.Google Scholar
- 9.van Assendelft, O.W. and Lewis, S.M. (1991). Recommended method for the determination of the haemoglobin concentration of blood. WHO Docum. Lab. 8 fold Rev. 1.Google Scholar
- 10.Drabkin, D.L. and Austin, J.H. (1932). Spectrophotometric studies: Spectrophotometric constant for common hemoglobin derivatives in human, dog and rabbit blood. J. Biol. Chem. 98, 719–733.Google Scholar
- 11.Ohkwa, M., Ohighi, N. and Yagi, K. (1979). Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Analyt. Biochem. 95, 357–358.Google Scholar
- 12.Chatterjee, C.C. (1983). Human Physiology. Volume II. Medical Allied Agency, India pp. 10–11.Google Scholar