Indian Journal of Clinical Biochemistry

, Volume 20, Issue 2, pp 192–194 | Cite as

Iron store and free radicals in thalassemia

  • K. Goswami
  • S. Ghosh
  • M. Bandyopadhyay
  • K. L. Mukherjee
Article

Abstract

Hyper-ferrous state is the result of multiple transfusions, whereby the iron excess in such conditions may be toxic to the organism. Patients suffering from thalassemia receive multiple transfusions. In the eastern part of India, both β0-thalassemia and heterozygous Eβ-thalassemia occur. This paper expresses the hyper-ferrous state, leading to iron overload in these two conditions and also reports the increased generation of free radicals, consequent to the iron overload.

Key words

Thalassemia Ferritin Malondialdehyde 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Conrad, M.E. (1998). Introduction: Iron overloading disorder and iron regulation. Seminars in Hematol. 35 (1), 1–4Google Scholar
  2. 2.
    Halberg, L. (1981). Bioavailability of dietary iron. Ann. Rev. Nutr. 1 (1), 123–125.CrossRefGoogle Scholar
  3. 3.
    McCord, J.M. (1992). Superoxide production and human disease. In Jesaitis, A. and Dratz, E. (eds.): Molecular basis of oxidative damage by leukocytes. Boca Raton. FL. CRC, pp. 225–239.Google Scholar
  4. 4.
    McCord, J.M. (1974). Free radicais and inflammation: Protection of synovial fluid by superoxide dismutase. Science 185, 159–163.CrossRefGoogle Scholar
  5. 5.
    Halliwell, B. and Gutteridge, J.M.C. (1992). Biologically relevant metal ion-dependent hydroxyl radical generation-An update. FEBS Lett. 307, 108–112.PubMedCrossRefGoogle Scholar
  6. 6.
    Gutteridge, J.M.C., Rowley, D.A. and Halliwell, B. (1982). Superoxide dependent formation of hydroxyl radicals and lipid peroxidation in the presence of iron salts. Biochem. J. 206, 605–609.PubMedGoogle Scholar
  7. 7.
    Biomond, P., Swaak, A.J. Bemdorff, C.M.et al. (1986). Superoxide dependent and independent mechanisms of iron mobilization from ferritin by xanthine oxidase implications for oxygen-free radical-induced tissue destruction during ischaemia and inflammation. Biochem. J. 239, 169–173.Google Scholar
  8. 8.
    Biemond, P. van Eijk, H.G., Swaak, A.J.G.et al.. (1984). Iron mobilization from ferritin by superoxide derived from stimulated polymorphonuclear leukocytes. Possible mechanism in inflammation diseases. J. Clin. Invest. 73, 1576–1579.PubMedCrossRefGoogle Scholar
  9. 9.
    van Assendelft, O.W. and Lewis, S.M. (1991). Recommended method for the determination of the haemoglobin concentration of blood. WHO Docum. Lab. 8 fold Rev. 1.Google Scholar
  10. 10.
    Drabkin, D.L. and Austin, J.H. (1932). Spectrophotometric studies: Spectrophotometric constant for common hemoglobin derivatives in human, dog and rabbit blood. J. Biol. Chem. 98, 719–733.Google Scholar
  11. 11.
    Ohkwa, M., Ohighi, N. and Yagi, K. (1979). Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Analyt. Biochem. 95, 357–358.Google Scholar
  12. 12.
    Chatterjee, C.C. (1983). Human Physiology. Volume II. Medical Allied Agency, India pp. 10–11.Google Scholar

Copyright information

© Association of Clinical Biochemists of India 2005

Authors and Affiliations

  • K. Goswami
    • 1
  • S. Ghosh
    • 1
  • M. Bandyopadhyay
    • 1
  • K. L. Mukherjee
    • 1
  1. 1.Dept of BiochemistryVivekananda Institute of Medical SciencesKolkataIndia

Personalised recommendations