Thienobenzothiopyranones III new 4H-thieno[2,3-b][1]benzothiopyran-4-ones carrying different heterocyclic moieties of expected pharmacological interest

  • H. I. El-Subbagh
  • A. A. El-Emam
  • M. B. El-Ashmawy
  • I. A. Shehata
Original Articles
Received:

Abstract

Reaction of 2-formyl-4H-thieno[2,3-b][1]benzothiopyran-4-one (1) with different heterocyclic amines afforded the corresponding Schiff's bases (2–4). Diethyl malonate, ethyl cyanoacetate and malononitrile were reacted with1 to afford compounds5,7 and8, respectively. Compound5 was cyclized to the pyrazolidin-3,4-dione (6) by the action of hydrazine hydrate, whereas compound7 was utilized for the synthesis of the thiazolin-4-one derivatives (9–13).

Keywords

Synthesis 4H-thieno[2,3-b][1]benzothiopyran-4-ones thiazolin-4-ones pyrazolidin-3,5-dione 
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Copyright information

© The Pharmaceutical Society of Korea 1990

Authors and Affiliations

  • H. I. El-Subbagh
    • 1
  • A. A. El-Emam
    • 1
  • M. B. El-Ashmawy
    • 1
  • I. A. Shehata
    • 1
  1. 1.Department of Medicinal Chemistry, Faculty of PharmacyUniversity of MansouraMansouraEgypt

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