Antioxidant activity of resveratrol closely correlates with its monoamine oxidase-A inhibitory activity

  • Yong Nam Han
  • Shi Yong Ryu
  • Byung Hoon Han
Original Articles


Polyhydroxystilbenes including resveratrol were reported to competitively inhibit monoamine oxidase-A without structural relation with substrates and synthetic inhibitors for the enzyme. We attempt to explore a plausible mechanism for their inhibitory activity on MAO-A. All the polyhydroxystilbenes tested showed the antioxidant activity on liver homogenate. Furthermore, the antioxidant activity turned out to closely correlate with the MAO-A inhibitory activity.


Antioxidant monoamine oxidase inhibitor resveratrol stilbene 


  1. 1.
    Han, Y.N., Noh, D.B. and Han, D.S.: Studies on the monoamine oxidase inhibitors of medicinal plants I. Isolation of MAO-B inhibitors fromChrysanthemum indicum, Arch. Pharm. Res. 10, 142 (1987).CrossRefGoogle Scholar
  2. 2.
    Ryu, S.Y., Han, Y.N., and Han, B.H.: Monoamine oxidase-A inhibitors from medicinal plants,Arch. Pharm. Res. 11, 230 (1988).CrossRefGoogle Scholar
  3. 3.
    Ho, B. T.: Monoamine oxidase inhibitors,J. Pharm. Sciences,61, 821 (1972).CrossRefGoogle Scholar
  4. 4.
    Murphy, D.L., Garrick, N.A., Aulakh, C.S. and Cohen, R.M.: New contributions from basic science to understanding the effects of monoamine oxidase inhibiting antidepressants,J. Clin. Psychiatry,45, 7 (Sec. 2)-July, 37 (1984).PubMedGoogle Scholar
  5. 5.
    Han, B.H., Park, M.H. and Han, Y.N.: Studies on the antioxidant components of Korean ginseng (V): The mechanism of antioxidant activity of maltol and phenolic acid,Korean Biochem. J. 18, 337 (1985).Google Scholar
  6. 6.
    Kimura, Y., Ohiminami, H., Okuda, H., Baba, K., Kozawa, M. and Arichi, S.: Effects of stilbene components of roots of Polygomum ssp. on liver injury in peroxidized oil-fed rats,Planta Media,49, 51 (1983).CrossRefGoogle Scholar
  7. 7.
    Inamori, Y., Kubo, M., Kato, Y., Yasuda, M., Baba, K. and Kozawa, M.: The antifugal activity of stilbene derivative,Chem. Pharm. Bull. 32, 801 (1984).PubMedGoogle Scholar
  8. 8.
    Goda, Y., Shibuya, M. and Sanakawa, U.: Inhibitors of the arachidonate cascade fromAllium chinense andin vitro platelet aggregation.Chem. Pharm. Bull. 35, 2668 (1987).PubMedGoogle Scholar
  9. 9.
    Han, Y. N., Baik, S. K., Kim, T.H. and Han, B.H.: Antithrombotic activities of saponins fromIlex pubescens, Arch. Pharm. Res. 10, 115 (1987).CrossRefGoogle Scholar
  10. 10.
    Hamberg, M., Svensson, J. and Samuelsson, E.: Prostaglandin endoperoxides, A new concept concerning the mode action and release of prostaglandins,Proc. Nat. Acad. Sci. USA,71, 3824 (1974).PubMedCrossRefGoogle Scholar
  11. 11.
    Tanaka, S., Kuwai, Y. and Tabata, M.: Isolation of monoamine oxidase inhibitor fromGlycyrrhiza uralensis roots and structure-activity relationship,Planta Medica,53, 5 (1987).PubMedGoogle Scholar
  12. 12.
    Yamazaki, M., Satoh, Y., Maebayashi, Y. and Horie, Y.: Monoamine oxidase inhibitors from fungus,Emericella navahoensis, Chem. Pharm. Bull. 36, 670 (1988).PubMedGoogle Scholar
  13. 13.
    Von Korff, R.W.: Monoamine oxidase: Structure, function and altered functions (Signer, T.P., Von Korff, R.W. and Murphy, D.L., eds.), p.1, Academic press, New York (1979).Google Scholar
  14. 14.
    Russell, S.M., Davey, J. and Mayer, R.L.: The vectorial orientation of human monoamine oxidase in the mitochondrial outer membrane,Biochem. J. 181, 7 (1979).PubMedGoogle Scholar
  15. 15.
    Abell, C.W.: Monoamine oxidase A and B from human liver and brain,Methods in Enzym. 142, 638 (1987).Google Scholar
  16. 16.
    Paech, C., Salach, J.I. and Singer, T.P.: Suicide inactivation of monoamine oxidase by transphenylcyclopropylamine. In: Singer, T.P., Von Korff, R.W. and Murphy, D.L. (eds.): Monoamine oxidase: Structure, function and altered functions, Academic Press, New York (1979).Google Scholar
  17. 17.
    Maycock, A.L., Abeles, R.H. and Salach J.I.: The structure of the covalent adduct formed by interaction of 3-dimethylamino-1-propyne and the flavin of mitochondrial amine oxidase,Biochem. 15, 114 (1976).CrossRefGoogle Scholar
  18. 18.
    Kenney, W.C., Nagy, J., and Salach, J.I.: Structure of the covalent phenylhydrazine adduct of monoamine oxidase. In Singer, T.P., Von Korff, R. W. and Murphy, D.L. (eds): Monoamine oxidase: Structure, function and altered functions, Academic Press, New York (1979).Google Scholar

Copyright information

© The Pharmaceutical Society of Korea 1990

Authors and Affiliations

  • Yong Nam Han
    • 1
  • Shi Yong Ryu
    • 1
  • Byung Hoon Han
    • 1
  1. 1.Natural Products Research InstituteSeoul National UniversitySeoulKorea

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