The crystal structure of fenbufen, 3-(4-biphenylylcarbonyl)propionic acid (C16H14O3), a non-steroidal antiinflammatory agent

  • Yang Bae Kim
  • Il Yeong Park
  • Yang Hwan Park
Original Articles


The crystal structure of fenbufen was determined by X-ray diffraction techniques. The compound was recrystallized in orthorhombic crystal system, space groupPca2 1 ,a=31.918(10),b=5.550(2),c=15.078(9) Å,D m =1.26,D x =1.264 g/cm3, andZ=8. The structure was solved by direct methods and refined by least-squares procedure to the finalR value of 0.051 for 1780 independent reflections. Two molecules in the asymmetric unit are related by a pseudo center of symmetry and dimerizedvia O−H…O hydrogen bonds. The carbonyl group attached to the phenyl ring is nearly coplanar to the ring. In the crystal the molecules are arranged in parallel stacks in thea direction.

Key words

non-steroidal antiinflammatory agent fenbufen X-ray diffraction 

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Copyright information

© The Pharmaceutical Society of Korea 1988

Authors and Affiliations

  • Yang Bae Kim
    • 1
  • Il Yeong Park
    • 1
  • Yang Hwan Park
    • 1
  1. 1.College of PharmacySeoul National UniversitySeoulKorea

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