Archives of Pharmacal Research

, Volume 9, Issue 2, pp 93–97 | Cite as

Studies on the constituents of PhilippinePiper betle leaves

  • Agnes M. Rimando
  • Byung Hoon Han
  • Jeong Hill Park
  • Magdalena C. Cantoria
Original Articles


Fourteen volatile components including eight allypyrocatechol analgos were isolated and identified from the essential oil and ether soluble fraction of PhilippinePiper betle leaves (Piperaceae). The major constituents of PhilippinePiper betle oil were chavibetol and chavibetol acetate. Capillary GC analysis of the oil showed chavibetol (53.1%), chavibetol acetate (15.5%), caryophyllene (3.79%), allypyroacatechol diacetate (0.71%), campene (0.48%), chavibetol methyl ether (=methyl eugenol, 0.48%), eugenol (0.32%), α-pinene (0.21%), β-pinene (0.21%), α-limonene (0,14%), safrole (0.11%), 1,8-cineol (0.04%), and allylpyrocatechol monoacetate. The major component of the ether soluble fraction was allylpyrocatechol (2.38% of the leaves).


Piper betle Piperaceae Essential oil Chavibetol Chavibetol acetate Caryophyllene Allypyrocatechol diacetate Campene Chavibetol methyl ether Eugenol α-Pinene β-Pinene α-limonene Safrole 1,8-Cineol Allypyrocatchol monoacetate Allypyrocatechol 


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Literature Cited

  1. 1.
    Krishnamurthi, A., Ed.-in-chief.:Wealth of India-Raw Materials. V. 8 CSIR, New Delhi, India, p 83 (1969).Google Scholar
  2. 2.
    Mercier, A.: The areca and the betle-Use of betle nut in the orient.Bull. Mens. Soc. Linn. Lyon.,13, 28 (1949).Google Scholar
  3. 3.
    Quisurnbing, E.:Medicinal Plants of the Philippiness. JMC Press, Inc., Quezon City, Philippines, (1978).Google Scholar
  4. 4.
    Evans, P.H., Bowers, W.S., and Funk, E.J.: Identification of fungicidal and nematocidal components in the leaves ofPiper betle.J. Agric. Food Chem.,32, 1254 (1984).CrossRefGoogle Scholar
  5. 5.
    Bangar, G.P., Rao, R.E., and Varma, K.C.: Antimicrobial activity of leaves and oil ofPiper betle.Ind. J. Pharm. 28, 327 (1966).Google Scholar
  6. 6.
    Ali, S.M. and Mehta, R.K.: Preliminary pharmacological and anthelmintic studies of the essential oil ofPiper betle.Ind. J. Pharm. 32, 132 (1970).Google Scholar
  7. 7.
    Ueda, E. and Sasaki, T.: Chemical studies of Formosan plants I, Chemical constitutuents of the leaves ofPiper betle.Yakugaku Zasshi 71, 559 (1951).Google Scholar
  8. 8.
    Atal, C.K., Dhar, K.L., and Singh, J.: The chemistry of IndianPiper species.Lloydia 38, 256(1975).PubMedGoogle Scholar
  9. 9.
    Sharma, M.L., Kawat, A.K.S., Balasabrahmanyan, V.R., and Singh, A.: Studies on the essential oil of betle vine leaf (Piper betle).Indian Perfuner 27, 91(1983).Google Scholar
  10. 10.
    Budzikiewicz, H., Djerassi, C., and Williams, D.H.:Structure Elucidation of Natural Products by Mass Spectrometry, Holden-day Inc., San Francisco, USA, p 17 (1964).Google Scholar
  11. 11.
    Buckingham, J.:Dictionary of Organic Compounds, 5th ed., V.5, Chapman and Hall, New York, USA, p 4785 (1982).Google Scholar

Copyright information

© The Pharmaceutical Society of Korea 1986

Authors and Affiliations

  • Agnes M. Rimando
    • 1
  • Byung Hoon Han
    • 1
  • Jeong Hill Park
    • 1
  • Magdalena C. Cantoria
    • 1
  1. 1.Natural Products Research InstituteSeoul National UniversitySeoulKorea

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