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Archives of Pharmacal Research

, Volume 6, Issue 2, pp 123–131 | Cite as

Antitumor activity of some phytobased polysaccharides and their effects on the immune function

  • Chang Kiu Moon
  • Kyl Soon Sim
  • Soo Hwan Lee
  • Kwang Sik Park
  • Yeo Pyo Yun
  • Bae-Jin Ha
  • Chong-Chul Lee
Original Articles

Abstract

Polysaccharide fractions were prepared from Ginseng root,Mori Radicis Cortex (M.R.C.),Phellodendri Cortex (Ph.C.),Sappan Wood (S.W.) andTigli Semen (T.S.). Water extract was also prepared from the mixture of Ph.C., S.W. and T.S. Ginseng polysaccharide and water extract of the mixture showed marked antitumor activity against sarcoma 180. Ginseng polysaccharide showed a mild increasing effect on the number of circulating leucocytes and a marked increasing effect on the number of plaque forming cells (PFC). Polysaccharides from ginseng root, S.W., Ph.C.+T.S. and water extract of the mixture showed dramatic inducing activities of peritoneal exudate cells (PEC), polymorphonuclear leucocytes (PMN) and macrophages. These results suggest the possibility that water extract of the mixture may have the lentinan like effect and ginseng polysaccharide may have stimulating effects on the general immune system.

Keywords

Polysaccharides Ginseng root Mori Radicis Cortex Phellodendri Cortex Sappan Wood, Tigli Semen Antitumor activity against sarcoma 180 Immunostimulating activity 

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Copyright information

© The Pharmaceutical Society of Korea 1983

Authors and Affiliations

  • Chang Kiu Moon
    • 1
  • Kyl Soon Sim
    • 1
  • Soo Hwan Lee
    • 1
  • Kwang Sik Park
    • 1
  • Yeo Pyo Yun
    • 1
  • Bae-Jin Ha
    • 1
  • Chong-Chul Lee
    • 2
  1. 1.College of PharmacySeoul National UniversitySeoul
  2. 2.Department of PharmacySanup UniversityBusanKorea

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