Archives of Pharmacal Research

, Volume 6, Issue 2, pp 123–131 | Cite as

Antitumor activity of some phytobased polysaccharides and their effects on the immune function

  • Chang Kiu Moon
  • Kyl Soon Sim
  • Soo Hwan Lee
  • Kwang Sik Park
  • Yeo Pyo Yun
  • Bae-Jin Ha
  • Chong-Chul Lee
Original Articles


Polysaccharide fractions were prepared from Ginseng root,Mori Radicis Cortex (M.R.C.),Phellodendri Cortex (Ph.C.),Sappan Wood (S.W.) andTigli Semen (T.S.). Water extract was also prepared from the mixture of Ph.C., S.W. and T.S. Ginseng polysaccharide and water extract of the mixture showed marked antitumor activity against sarcoma 180. Ginseng polysaccharide showed a mild increasing effect on the number of circulating leucocytes and a marked increasing effect on the number of plaque forming cells (PFC). Polysaccharides from ginseng root, S.W., Ph.C.+T.S. and water extract of the mixture showed dramatic inducing activities of peritoneal exudate cells (PEC), polymorphonuclear leucocytes (PMN) and macrophages. These results suggest the possibility that water extract of the mixture may have the lentinan like effect and ginseng polysaccharide may have stimulating effects on the general immune system.


Polysaccharides Ginseng root Mori Radicis Cortex Phellodendri Cortex Sappan Wood, Tigli Semen Antitumor activity against sarcoma 180 Immunostimulating activity 


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Literature Cited

  1. 1).
    Yoon, T. K.: An experimental study on tumor inhibitory effect of red ginseng in mice and rats exposed to various chemical carcinogens.Proceedings of the 3rd International Ginseng Symposium 87 (1980).Google Scholar
  2. 2).
    Richard, I. and Malcolm, S.U.: Modulation of the immune response by BCG: A review.The Yale J. Bio. Mod. 49, 283(1976).Google Scholar
  3. 3).
    Chihara, G., Hamuro, J. and Maeda, Y.: Fractionation and purification of the polysaccharides with marked antitumor activity, especially lentinan, fromLentinus edodes (an edible mushroom).Cancer Res. 30, 2776(1970).PubMedGoogle Scholar
  4. 4).
    Matsuo, T.: Pharmacological and Toxicological Studies of a New Antitumor Polysaccharide, Schizophyllan.Arzneim-Forsch,32, 647 (1982).Google Scholar
  5. 5).
    Maeda, Y. and Chihara G.: The effect of neonatal thymectomy on the antitumor activity of lentinan, carboxymethylpachymaran and zymosan and their effects on various immune responses.Int. J. Cancer 11, 153 (1973).PubMedCrossRefGoogle Scholar
  6. 6).
    Maeda, Y.: Antitumor polysaccharides and host defense against cancer: A new way for cancer immuno-chemotherapy.Protein Nucleotide Enzyme 21, 425 (1976).Google Scholar
  7. 7).
    Cha, S.M.: Potential anticancer medicinal plants. A statistical evaluation of their frequencies of appearance in oriental medicine formularies.Kor. J. Pharmacog. 8, 1 (1977).Google Scholar
  8. 8).
    Yan, S. and Evan, M.H.: Immune restoration and/or augmentation of local graft versus host reaction by traditional chinese medicinal herbs.Cancer 52, 70 (1983).CrossRefGoogle Scholar
  9. 9).
    Caldes, G.: Characterization of a polysaccharide fromCarthamus tinctorius that cross reacts with type III pneumococcal polysaccharide.J. Gen. Appl. Microbiol. 27, 157 (1981).CrossRefGoogle Scholar
  10. 10).
    Cunningham, A.J. and Szenberg, A.: Further improvements in the plaque technique for detecting single antibody forming cells.Immunology 14, 599 (1968).PubMedGoogle Scholar
  11. 11).
    Yamm, L.T., Li, C.Y. and Crosby, W.H.: Cytochemical identification of monocyte and granulocyte.Am. J. Clin. Pathol. 55, 283 (1971).Google Scholar
  12. 12).
    Instruction 14,Screening Data Summary Interpretation and Outline of Current Screen, NCI. U.S.A.Google Scholar
  13. 13).
    Tsunawaki, S.: Induction of polymorphonuclear leucocote mediated cytolysis by wheat germ agglutinin and antitumor antibody.Gann 74, 258 (1983).PubMedGoogle Scholar
  14. 14).
    Tsunawaki, S.: Mechanisms of lectin ann antibody dependent polymorphonuclear leucocyte mediated cytolysis.Gann 74, 265(1983).PubMedGoogle Scholar
  15. 15).
    Yamazaki, M.: Polymorphonuclear leucocyte mediated cytolysis induced by animal lectin.Gann 47, 576 (1983).Google Scholar
  16. 16).
    Fisher, B., and Saffer, A.E.: Tumor cell cytotoxicity by granulocytes from peripheral blood of tumor-bearing mice.J. Natl. Cancer. Inst. 60, 687(1978).PubMedGoogle Scholar
  17. 17).
    Gerrard, T.L., Cohen, D.J. and Kaplan, A.M.: Human neutrophilmediated cytotoxicity to tumor cells.J. Natl. Cancer Inst. 66, 483 (1981).PubMedGoogle Scholar
  18. 18).
    Clark, R.A. and Klebanoff, S.J.: Neutrophilmediated tumor cell cytotoxicity: role of the peroxidase system.J. Exp. Med. 141, 1442 (1975).PubMedCrossRefGoogle Scholar
  19. 19).
    Nathan, C.F., Brukner, L.H., Silverstein, S.C. and Cohn, Z.A.: Extracellular cytolysis by activated macrophages and granulocytes.J. Exp. Med. 149, 84 (1979).PubMedCrossRefGoogle Scholar
  20. 20).
    Kurashige, S. and Mitshashi, S.: Macrophage activities in sarcoma 180-bearing mice and EL4-bearing mice.Gann 73, 85 (1982).PubMedGoogle Scholar
  21. 21).
    Saito, H. and Tomioka, H.: Suppressive factor against macrophage phagocytosis produced by cultured sarcoma 180 cells.Gann 70, 671 (1979).PubMedGoogle Scholar
  22. 22).
    Weinberg, J.B.: In vino modulation of macrophage tumoricidal activity: enhanced tumor cell killing by peritoneal macrophages from mice given injections of sodium periodate.J. Natl. Cancer Inst. 66, 529 (1981).PubMedGoogle Scholar
  23. 23).
    Ito, M.: Superoxide anion and hydrogen peroxide release by macrophages from mice treated withNocardia rubra cell-wall skeleton: inhibition of macrophage cytotoxicity by a protease inhibitor but not by supperoxide and catalase.Gann 74, 128 (1983).PubMedGoogle Scholar
  24. 24).
    Yamazaki, M.: Marine animal lectin-dependent tumor recognition by macrophages.gann 74, 405 (1983).PubMedGoogle Scholar
  25. 25).
    Mashiba, H.: The role of macrophages in preventing metastasis of a homotransplantable hamster lymphoma.Gann 74, 548 (1983).PubMedGoogle Scholar

Copyright information

© The Pharmaceutical Society of Korea 1983

Authors and Affiliations

  • Chang Kiu Moon
    • 1
  • Kyl Soon Sim
    • 1
  • Soo Hwan Lee
    • 1
  • Kwang Sik Park
    • 1
  • Yeo Pyo Yun
    • 1
  • Bae-Jin Ha
    • 1
  • Chong-Chul Lee
    • 2
  1. 1.College of PharmacySeoul National UniversitySeoul
  2. 2.Department of PharmacySanup UniversityBusanKorea

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