First derivative spectrophotometric and gas-liquid chromatographic determination of caffeine in foods and pharmaceuticals III. Simultaneous assay of caffeine and some antihistaminics
Two different, derivative spectrophotometric and gas-liquid chromatographic, procedures for direct quantitation of caffeine and some commonly dispensed antihistaminics in bulk forms, in their laboratory prepared mixtures and in dosage formulations, have been investigated. The limit, sensitivity, reproducibility and accuracy of each method were studied for each individual drug substance and in some usual pharmaceutical formulations.
KeywordsCaffeine antihistamine first derivative spectrophotometric determination gas-liquid chromatographic determination
Burger, A. (Ed.): Medicinal Chemistry, 2nd Edn., Inc., New York, p.531, (1960).Google Scholar
Ismaiel, S. A.: Determination of antazoline and diphenhydramine in some pharmaceutical preparations containing ephedrine,Pharmazie
, 423 (1974).PubMedGoogle Scholar
Matsui, F. and French, W. N.: Analysis of binary mixtures of pharmaceutical amines by the acid-Dye technique,J. Pharm. Sci.
, 287 (1971).PubMedCrossRefGoogle Scholar
Sakai, F. and Ohno, N.: Use of thermochromism of associate for the determination of antihistamine drugs in pharmaceutical preparations and urine,Analyst
, 634 (1982).PubMedCrossRefGoogle Scholar
Sperling, A. R.: Analysis of phenothiazine in syrups,J. Pharm. Sci.
, 98 (1967).PubMedCrossRefGoogle Scholar
Cosofert, V. V. and Buck, R. P. P.: Phenothiazine drugs poly (vinyl chloride) matrix membrane electrode and their use in pharmaceutical analysis,Analyst
, 1321 (1984).CrossRefGoogle Scholar
Newton, J. M.: Spectrophotometric determination of caffeine in coffee products (Collaborative Study),J. Assoc. Off. Anal. Chem.
, 705 (1979).PubMedGoogle Scholar
Sjoberg, A. M. and Rajama, J.: Simple method for the determination of alkaloids in cocoa using paper chromatography and UV-spectrometry,J. Chromatogr.
, 291 (1984).PubMedCrossRefGoogle Scholar
Vitzthum, O., Barthels, M. and Kwasny, H.: Rapid method for the determination of caffeine in caffeine-containing and decaffeinated coffee by gas chromatography with the nitrogen-sensitive detector,Z. Lebensm. Unters.-Forsch.
, 135 (1974).CrossRefGoogle Scholar
Blauch, J. L. and Tarka Jr., S. M.: HPLC-Determination of caffeine and theobromine in coffee, tea and instant hot coca mixes,J. Food Sci.
, 745 (1983).CrossRefGoogle Scholar
The British Pharmacopoeia 1988, HMS Office, London, pp.84,131,359, & 428.Google Scholar
The United States Pharmacopoeia XXI, US Pharmacopoeial Convention, Rockville-MD., 1985, pp.143,202, & 921.Google Scholar
Abdel-Moety, E. M. and Moustafa, A. A.: First-derivative spectrophotometric and gas-liquid chromatographic determination of caffeine in food products and pharmaceuticals. II. Simultaneous assay of caffeine and procaine hydrochloride (Novocaine) in binary mixtures and in geriatrics,Norv. Pharm. Acta
, 75 (1986).Google Scholar
Abdel-Moety, E. M.: First-derivative spectrophotometric and gas-liquid chromatographic determination of caffeine in foods and pharmaceuticals. I. Rapid determination of caffeine in coffee, tea and soft drinks,Z. Lebensm.-Unters. Forsch.
, 412 (1988).PubMedCrossRefGoogle Scholar
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