Archives of Pharmacal Research

, Volume 1, Issue 1, pp 7–11 | Cite as

Sedative action of spinosin

  • Kuk Hyun Shin
  • Chung Kyu Lee
  • Won Sick Woo
  • Sam Sik Kang
Original Articles


The acute toxicity and the sedative action of spinosin isolated fromZizyphus seeds have been tested with mice.

Spinosin possessed a very weak toxicity and at relatively high dose showed a significant sedative action in a ladder-climbing test, a potentiation of hexobarbital-induced hypnosis and an antagonistic effect on caffeine-induced hyperactivity.


The seeds ofZizyphus vulgaris var.spinosus spinosin sedative action ladder climbing test-potentiation of hypnosis antagonistic effect to hyperactivity 


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Copyright information

© The Pharmaceutical Society of Korea 1978

Authors and Affiliations

  • Kuk Hyun Shin
    • 1
  • Chung Kyu Lee
    • 1
  • Won Sick Woo
    • 1
  • Sam Sik Kang
    • 1
  1. 1.Natural Products Research InstituteSeoul National UniversitySeoulKorea

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