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Archives of Pharmacal Research

, Volume 4, Issue 2, pp 133–135 | Cite as

3-Bromo-5,5-dimethylhydantoin induced ring closure(I)

Bromolactonization
  • Chae-ho Cook
  • You-sup Chung
Communications

Abstract

Reaction of unsaturated acids with 3-bromo-5,5-dimethylhydantoin in dry DMF at room temperature gives bromolactones in 58–91% yields.

Keywords

Bromolactonization 3-Bromo-5,5-dimethylhydantoin N,N-Dimethylformamide γ-Bromo-β-lactone 

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Copyright information

© The Pharmaceutical Society of Korea 1981

Authors and Affiliations

  • Chae-ho Cook
    • 1
  • You-sup Chung
    • 1
  1. 1.College of PharmacySeoul National UniversitySeoulKorea

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