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Archives of Pharmacal Research

, 12:154 | Cite as

Pharmacokinetics and renal excretion of sulfamethoxazole in sheep

  • Bukhtiar Husain Shah
  • M. Mawaz
  • Ijaz Javed
  • Anwar-ul-Hassan Gilani
Original Articles

Abstract

Pharmacokinetics and urinary excretion of sulfamethoxazole were investigated in healthy sheep. From the plasma disappearance curves after intravenous bolus injection (50 mg/kg), the half-life and volume of distribution were found to be 76±14 min and 0.41±0.18 lit/kg respectively. Body clearance was 4.06±1.03 ml/kg/min. Very low Concentration of drug was present in plasma after 3 hours of administration and plasma level at 6 hour was only 4.4±2.0 μg/ml. The renal clearance of sulfamethoxazole (22±2.17 ml/min/10 kg) exceeded the creatinine clearance (9.78±1.57 ml/min/10 kg) which may be due to involvement of active tubular secretion and pH dependent back diffusion. Half of the dose of sulfamethoxazole was excreted as unchanged free drug while acetylated amine comprised of 20 percent within the first 6 hours of drug administration.

Keywords

Pharmacokinetics Renal excretion Sulfamethoxazole Sheep 

Literature Cited

  1. 1.
    Nawaz, M.: Renal clearance of sulfadimidine in sheep.Proc. 2nd Cong. Eur. Assoc. Vet. Pharmacol. Toxicol., France, INRA Publications,5, 193 (1982).Google Scholar
  2. 2.
    Nawaz, M.: Research on imported drugs.Pak. Vet. J. 3, 11 (1983).Google Scholar
  3. 3.
    Afzal, G., Nawaz, M. and Saleem, B.: Factors affecting disposition kinetics of sulfadimidine in animals.Pak. Vet. J. 2, 57 (1982).Google Scholar
  4. 4.
    Nawaz, M. and Shah, B.H.: Renal clearance of endogenous creatinine and urea in sheep during summer and winter.Res. Vet. Sci. 36, 220 (1984).PubMedGoogle Scholar
  5. 5.
    Vree, T.B., Reilly, O., Hekster, Y.A., Dasma, J.E. and Kleijn, E.V.: Determination of the acetylator phenotype and pharmacokinetics of some sulfonamides in man.Clin. Pharmacokin. 5, 279 (1980).CrossRefGoogle Scholar
  6. 6.
    Bratton, A.C., and Marshall, E.K.: A new coupling component for sulfanilamide determination.J. Biol. Chem. 128, 537 (1939).Google Scholar
  7. 7.
    Bonsness, R.W. and Tausky, H.H.: On the colorimetric determination of creatinine by the Jaffe-reaction.J. Biol. Chem. 158, 581 (1945).Google Scholar
  8. 8.
    Neilsen, P. and Rausmussen, F.: Renal excretion of sulfanilamide, sulfadimidine, and sulfamethoxazole in goats.Res. Vet. Sci. 22, 205 (1977).Google Scholar
  9. 9.
    Gogh, H.V.: Pharmacokinetics of nine sulfonamides in goats.J. Vet. Pharmacol. Therap. 3, 69 (1980).CrossRefGoogle Scholar
  10. 10.
    Nawaz, M. and Khan, F.H.: Pharmacokinetics and urinary excretion of sulfadimidine in sheep and goat.J. Vet. Pharmacol. Therap. 2, 129 (1979).CrossRefGoogle Scholar
  11. 11.
    Youssef, S.A.H., El-Gendi, A.Y.I., El-Sayed, M.G.A. and Arts, T.H.M.:J. Vet. Pharmacol. Therap. 4, 173 (1981).CrossRefGoogle Scholar
  12. 12.
    Shah, B.H. and Nawaz, M., Javed, I.: Disposition kinetics, dosage and urinary excretion of sulfamethylphenazole in sheep.Pak. Vet. J. 4, 1 (1984).Google Scholar
  13. 13.
    Vree, T.B., Reekers-Ketting, J.J., Nouws, J.F.M. and Arts, T.H.M.: Half-life apparent volume of distribution and protein binding of some sulfonamides in cows.J. Vet. Pharmacol. Therap. 4, 173 (1983).Google Scholar
  14. 14.
    Jorgensen, S.T. and Rausmussen, F.: Renal excretion of sulfanilamide sulfadimidine and sulfamethoxazole in goats.Nord. Vet. Med. 24, 601 (1972).PubMedGoogle Scholar
  15. 15.
    Baggot, J.D.: Some aspects of drug persistance in domestic animals.Res. Vet. Sci. 11, 130 (1970).PubMedGoogle Scholar
  16. 16.
    Dettli, C. and Spring, P.: Pharmacokinetic der chemotherapeutika.Rogenburger Jahrbuch fur arzliche Fortbildung B. 14, 17 (1966).Google Scholar
  17. 17.
    Vree, T.B., Hekster, Y.A., Hafkenscheid, J.C.M., Dalen, R.V. and Friesen, W.T.: Pharmacokinetics and mechanism of renal excretion of short acting sulfonamides and N-4 acetylsulfonamide derivatives in man.Eur. J. Clin. Pharmacol. 20, 283 (1981).PubMedCrossRefGoogle Scholar
  18. 18.
    Ueda, M., Orita, K. and Koizuiye, T.: Studies on the metabolism of drug XII. Quantitative separation of metabolites in human being after oral administration of sulfamethoxazole and sulfaphenazole.Chem. Pharmacol. Bulletin,20, 2047 (1972).Google Scholar

Copyright information

© The Pharmaceutical Society of Korea 1989

Authors and Affiliations

  • Bukhtiar Husain Shah
    • 1
  • M. Mawaz
    • 1
  • Ijaz Javed
    • 1
  • Anwar-ul-Hassan Gilani
    • 2
  1. 1.Department of Physiology and PharmacologyUniversity of AgricultureFaisalabadPakistan
  2. 2.Department of PharmacologyThe Aga Khan University Medical CollegeKarachiPakistan

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