The AAPS Journal

, Volume 8, Issue 2, pp E239–E253 | Cite as

Drug discovery from natural sources

  • Young-Won Chin
  • Marcy J. Balunas
  • Hee Byung Chai
  • A. Douglas Kinghorn
Article

Abstract

Organic compounds from terrestrial and marine organisms have extensive past and present use in the treatment of many diseases and serve as compounds of interest both in their natural form and as templates for synthetic modification. Over 20 new drugs launched on the market between 2000 and 2005, originating from terrestrial plants, terrestrial microorganisms, marine organisms, and terrestrial vertebrates and invertebrates, are described. These approved substances, representative of very wide chemical diversity, together with several other natural products or their analogs undergoing clinical trials, continue to demonstrate the importance of compounds from natural sources in modern drug discovery efforts.

Keywords

natural products drug discovery terrestrial plants terrestrial microorganisms marine organisms terrestrial vertebrates terrestrial invertebrates chemical diversity 

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Copyright information

© American Association of Pharmaceutical Scientists 2006

Authors and Affiliations

  • Young-Won Chin
    • 1
  • Marcy J. Balunas
    • 1
    • 2
  • Hee Byung Chai
    • 1
  • A. Douglas Kinghorn
    • 1
  1. 1.Division of Medicinal Chemistry and Pharmacognosy, College of PharmacyThe Ohio State UniversityColumbus
  2. 2.Program for Collaborative Research in the Pharmaceutical Sciences, Department of Medicinal Chemistry and Pharmacognosy, College of PharmacyUniversity of Illinois at ChicagoChicago

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