Advances in Therapy

, Volume 17, Issue 2, pp 117–131

Use of ambulatory blood pressure monitoring to compare antihypertensive efficacy and safety of two angiotensin II receptor antagonists, losartan and valsartan

  • Victor H. Monterroso
  • Victor Rodriguez Chavez
  • Evert T. Carbajal
  • Daniel R. Vogel
  • Gustavo J. Aroca Martinez
  • Luis H. Garcia
  • Jorge H. B. Cuevas
  • Joffre LaraTeran
  • Gerhart Hitzenberger
  • Pedro Leao Neves
  • Shirley J. Middlemost
  • Thomas Dumortier
  • Antonius M. G. Bunt
  • Ronald D. Smith
Article

DOI: 10.1007/BF02854844

Cite this article as:
Monterroso, V.H., Chavez, V.R., Carbajal, E.T. et al. Adv Therapy (2000) 17: 117. doi:10.1007/BF02854844

Abstract

The efficacy and safety of Iosartan and valsartan were evaluated in a multicenter, double-blind, randomized trial in patients with mild to moderate essential hypertension. Blood pressure responses to once-daily treatment with either losartan 50 mg (n = 93) or valsartan 80 mg (n = 94) for 6 weeks were assessed through measurements taken in the clinic and by 24-hour ambulatory blood pressure monitoring (ABPM). Both drugs significantly reduced clinic sitting systolic (SiSBP) and diastolic blood pressure (SiDBP) at 2, 4, and 6 weeks. Maximum reductions from baseline in SiSBP and SiDBP on 24hour ABPM were also significant with the two treatments. The reduction in blood pressure was more consistent across patients in the losartan group, as indicated by a numerically smaller variability in change from baseline on all ABPM measures, which achieved significance at peak (P = .017) and during the day (P = .002). In addition, the numerically larger smoothness index with losartan suggested a more homogeneous antihypertensive effect throughout the 24-hour dosing interval. The anti hypertensive response rate was 54% with losartan and 46% with valsartan. Three days after discontinuation of therapy, SiDBP remained below baseline in 73% of losartan and 63% of valsartan patients. Both agents were generally well tolerated. Losartan, but not valsartan, significantly decreased serum uric acid an average 0.4 mg/dL at week 6. In conclusion, once-daily losartan 50 mg and valsartan 80 mg had similar anti hypertensive effects in patients with mild to moderate essential hypertension. Losartan produced a more consistent blood pressure-lowering response and significantly lowered uric acid, suggesting potentially meaningful differences between these two A II receptor antagonists.

Keywords

angiotensin II antagonist uric acid valsartan losartan ambulatory blood pressure monitoring (ABPM) 

Copyright information

© Health Communications Inc 2000

Authors and Affiliations

  • Victor H. Monterroso
    • 1
  • Victor Rodriguez Chavez
    • 2
  • Evert T. Carbajal
    • 3
  • Daniel R. Vogel
    • 3
  • Gustavo J. Aroca Martinez
    • 4
  • Luis H. Garcia
    • 5
  • Jorge H. B. Cuevas
    • 6
  • Joffre LaraTeran
    • 7
  • Gerhart Hitzenberger
    • 8
  • Pedro Leao Neves
    • 9
  • Shirley J. Middlemost
    • 10
  • Thomas Dumortier
    • 11
  • Antonius M. G. Bunt
    • 12
  • Ronald D. Smith
    • 12
  1. 1.Hospital San Juan de DiosCiudadGuatemala
  2. 2.Clinica Maison de SanteHospital FAP Comandante J. B. DoricLimaPeru
  3. 3.Hospital Regional EspanolArgentina
  4. 4.Clinica Renal de la CostaBarranquillaColombia
  5. 5.Hosital Universitario San JorgePereiraColombia
  6. 6.Morones PrietoMonterreyMexico
  7. 7.Panamerican ClinicGuayaquilEcuador
  8. 8.Society for Clinical PharmacologyViennaAustria
  9. 9.Hospital de FaroFaroPortugal
  10. 10.Johannesburg General HospitalParktownSouth Africa
  11. 11.MSD-CBARDSBrusselsBelgium
  12. 12.Merck & Co., Inc.Whitehouse StationUSA

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