Advances in Therapy

, Volume 22, Issue 4, pp 313–356 | Cite as

Medication adherence and persistence: A comprehensive review

  • Kem P. Krueger
  • Bruce A. Berger
  • Bill Felkey
Article

Abstract

Estimates of adherence to long-term medication regimens range from 17% to 80%, and nonadherence (or nonpersistence) can lead to increased morbidity, mortality, and healthcare costs. Multifaceted interventions that target specific barriers to adherence are most effective, because they address the problems and reinforce positive behaviors. Providers must assess their patients’ understanding of the illness and its treatment, communicate the benefits of the treatment, assess their patients’ readiness to carry out the treatment plan, and discuss any barriers or obstacles to adherence that patients may have. A positive, supporting, and trusting relationship between patient and provider improves adherence. Individual patient factors also affect adherence. For example, conditions that impair cognition have a negative impact on adherence. Other factors—such as the lack of a support network, limited English proficiency, inability to obtain and pay for medications, or severe adverse effects or the fear of such effects—are all barriers to adherence. There are multiple reasons for nonadherence or nonpersistence; the solution needs to be tailored to the individual patient’s needs. To have an impact on adherence, healthcare providers must understand the barriers to adherence and the methods or tools needed to overcome them. This report describes the barriers to medication adherence and persistence and interventions that have been used to address them; it also identifies interventions and compliance aids that practitioners and organizations can implement.

Keywords

adherence behavioral change intervention model persistence 

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References

  1. 1.
    Demyttenaere K. Noncompliance with antidepressants: who’s to blame? Int Clin Psychopharmacol. 1998;13(suppl 2):S19-S25.PubMedCrossRefGoogle Scholar
  2. 2.
    Partridge AH, Avorn J, Wang PS, Winer EP. Adherence to therapy with oral antineoplastic agents. J Nat Cancer Inst. 2002;94:652–661.PubMedGoogle Scholar
  3. 3.
    Schoen MD, Di Domenico RJ, Connor SE, Dischler JE, Bauman JL. Impact of the cost of prescription drugs on clinical outcomes in indigent patients with heart disease. Pharmacotherapy. 2001;21: 1455–1463.PubMedCrossRefGoogle Scholar
  4. 4.
    Solomon DK, Portner TS, Bass GE, et al. Clinical and economic outcomes in the hypertension and COPD arms of a multicenter outcomes study. J Am Pharm Assoc. 1998;38:574–585.Google Scholar
  5. 5.
    Miura T, Kojima R, Mizutani M, Shiga Y, Takatsu F, Suzuki Y. Effect of digoxin noncompliance on hospitalization and mortality in patients with heart failure in long-term therapy: a prospective cohort study. Eur J Clin Pharmacol. 2001;57:77–83.PubMedCrossRefGoogle Scholar
  6. 6.
    Sellwood W, Tarrier N. Demographic factors associated with extreme non-compliance in schizophrenia. Soc Psychiatry Psychiatr Epidemiol. 1994;29:172–177.PubMedGoogle Scholar
  7. 7.
    Lesaffre E, Kocmanova D, Lemos PA, Disco CM, Serruys PW. A retrospective analysis of the effect of noncompliance on time to first major adverse cardiac event in LIPS. Clin Ther. 2003; 25:2431–2447.PubMedCrossRefGoogle Scholar
  8. 8.
    Balkrishnan R, Christensen DB. Inhaled corticosteroid nonadherence and immediate avoidable medical events in older adults with chronic pulmonary ailments. J Asthma. 2000;37:511–517.PubMedCrossRefGoogle Scholar
  9. 9.
    Lecompte D, Pelc I. A cognitive-behavioral program to improve compliance with medication in patients with schizophrenia. Int J Ment Health. 1996;25:51–56.Google Scholar
  10. 10.
    Rzewuska M. Drug maintenance treatment compliance and its correlation with the clinical picture and course of schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 26:811–814.Google Scholar
  11. 11.
    Kemp R, Hayward P, Applewhaite G, Everitt B, David A. Compliance therapy in psychotic patients: randomised controlled trial. BMJ. 1996;312:345–349.PubMedGoogle Scholar
  12. 12.
    Lin EH, Von Korff M, Ludman EJ, et al. Enhancing adherence to prevent depression relapse in primary care. Gen Hosp Psychiatry. 2003;25:303–310.PubMedCrossRefGoogle Scholar
  13. 13.
    Miklowitz DJ, George EL, Richards JA, Simoneau TL, Suddath RL. A randomized study of family-focused psychoeducation and pharmacotherapy in the outpatient management of bipolar disorder. Arch Gen Psychiatry. 2003;60:904–912.PubMedCrossRefGoogle Scholar
  14. 14.
    Rapoff MA, Belmont J, Lindsley C, Olson N, Morris J, Padur J. Prevention of nonadherence to nonsteroidal anti-inflammatory medications for newly diagnosed patients with juvenile rheumatoid arthritis. Health Psych. 2002;21:620–623.CrossRefGoogle Scholar
  15. 15.
    Razali SM, Hasanah CI, Khan UA, Subramaniam M. Psychosocial interventions for schizophrenia. Ment Health. 2000;9:283–289.CrossRefGoogle Scholar
  16. 16.
    Saunders B, Wilkinson C, Phillips M. The impact of a brief motivational intervention with opiate users attending a methadone programme. Addiction. 1995;90:415–424.PubMedCrossRefGoogle Scholar
  17. 17.
    Margolin A, Avants S, Warburton LA, Hawkins KA, Shi J. A randomized clinical trial of a manualguided risk reduction intervention for HIV-positive injection drug users. Health Psychol. 2003; 22:223–228.PubMedCrossRefGoogle Scholar
  18. 18.
    Schaffer SD, Tian L. Promoting adherence: effects of theory-based asthma education. Clin Nurs Res. 2004;13:69–89.PubMedCrossRefGoogle Scholar
  19. 19.
    Schmaling KB, Blume AW, Afari N. A randomized controlled pilot study of motivational interviewing to change attitudes about adherence to medications for asthma. J Clin Psychol Med Settings. 2001;8:167–172.CrossRefGoogle Scholar
  20. 20.
    Ngoh LN, Shepherd, MD. Design, development, and evaluation of visual aids for communicating prescription drug instructions to nonliterate patients in rural Cameroon. Patient Educ Couns. 1997; 31:245–261.PubMedCrossRefGoogle Scholar
  21. 21.
    Bouvy ML, Heerdink ER, Urquhart J, Grobbee DE, Hoe AW, Leufkens HG. Effect of a pharmacist-led intervention on diuretic compliance in heart failure patients: a randomized controlled study. J Cardiac Fail. 2003;9:404–411.CrossRefGoogle Scholar
  22. 22.
    Cramer JA, Rosenheck R. Enhancing medication compliance for people with serious mental illness. J Nerv Ment Dis. 1999;187:53–55.PubMedCrossRefGoogle Scholar
  23. 23.
    Katon W, Rutter C, Ludman EJ, et al. A randomized trial of relapse prevention of depression in primary care. Arch Gen Psychiatry. 2001;58:241–247.PubMedCrossRefGoogle Scholar
  24. 24.
    Katon W, Von Korff M, Lin E, et al. Collaborative management to achieve treatment guidelines: impact on depression in primary care. JAMA. 1995;273:1026–1031.PubMedCrossRefGoogle Scholar
  25. 25.
    Peveler R, George C, Kinmonth AL, Campbell M, Thompson C. Effect of antidepressant drug counseling and information leaflets on adherence to drug treatment in primary care: randomised controlled trial. BMJ. 1999;319:612–615.PubMedGoogle Scholar
  26. 26.
    Tan AS, Yong LS, Wan S, Wong ML. Patient education in the management of diabetes mellitus. Singapore Med J. 1997;38:156–160.PubMedGoogle Scholar
  27. 27.
    Rand CS, Nides M, Cowles MK, Wise RA, Connett J. Long-term metered-dose inhaler adherence in a clinical trial. The Lung Health Study Research Group. Am J Respir Crit Care Med. 1995;152: 580–588.PubMedGoogle Scholar
  28. 28.
    Dixon L, Weiden P, Torres M, Lehman A. Assertive community treatment and medication compliance in the homeless mentally ill. Am J Psychiatry. 1997;154:1302–1304.PubMedGoogle Scholar
  29. 29.
    Gani F, Pozzi E, Crivellaro MA, et al. The role of patient training in the management of seasonal rhinitis and asthma: clinical implications. Allergy. 2001;56:65–68.PubMedCrossRefGoogle Scholar
  30. 30.
    Lowe CJ, Raynor DK, Purvis J, Farrin A, Hudson J. Effects of a medicine review and education programme for older people in general practice. Br J Clin Pharmacol. 2000;50:172–175.PubMedCrossRefGoogle Scholar
  31. 31.
    Piette JD, Weinberger M, McPhee SJ, Mah CA, Kraemer FB, Crapo LM. Do automated calls with nurse follow-up improve self-care and glycemic control among vulnerable patients with diabetes? Am J Med. 2000;108:20–27.PubMedCrossRefGoogle Scholar
  32. 32.
    Stewart AV, Eales CJ, Davis KA. Effect of a telephonic intervention on the adherence of patients with hypertension. S Afr J Physiother. 2003;5:29–36.Google Scholar
  33. 33.
    Sturgess IK, McElnay JC, Hughes CM, Crealey G. Community pharmacy based provision of pharmaceutical care to older patients. Pharm World Sci. 2003;25:218–226.PubMedCrossRefGoogle Scholar
  34. 34.
    Varma S, McElnay JC, Hughes CM, Passmore AP, Varma M. Pharmaceutical care of patients with congestive heart failure: interventions and outcomes. Pharmacotherapy. 1999;19:860–869.PubMedCrossRefGoogle Scholar
  35. 35.
    Bukstein DA, Bratton DL, Firriolo KM, et al. Evaluation of parental preference for the treatment of asthmatic children aged 6 to 11 years with oral montelukast or inhaled cromolyn: a randomized, open-label, crossover study. J Asthma. 2003;4:475–485.CrossRefGoogle Scholar
  36. 36.
    Doren M, Reuther G, Minne HW, Schneider HP. Superior compliance and efficacy of continuous combined oral estrogen-progestogen replacement therapy in postmenopausal women. Am J Obstet Gynecol. 1995;173:1446–1451.PubMedCrossRefGoogle Scholar
  37. 37.
    Laine L, Estrada R, Trujillo M, Fukanaga K, Neil G. Randomized comparison of differing periods of twice-a-day triple therapy for the eradication of Helicobacter pylori. Aliment Pharmacol Ther. 1996;10:1029–1033.PubMedCrossRefGoogle Scholar
  38. 38.
    Mounier-Vehier C, Bernaud C, Carre A, Lequeuche B, Hotton JM, Charpentier JC. Compliance and antihypertensive efficacy of amlodipine compared with nifedipine slow-release. Am J Hypertens. 1998;11(4 pt 1):478–486.PubMedCrossRefGoogle Scholar
  39. 39.
    Stoloff SW, Stempel DA, Meyer J, Stanford RH, CarranzaRosenzweig JR. Improved refill persistence with fluticasone propionate and salmeterol in a single inhaler compared with other controller therapies. J Allergy Clin Immunol. 2004;113:245–251.PubMedCrossRefGoogle Scholar
  40. 40.
    Taylor AA, Shoheiber O. Adherence to antihypertensive therapy with fixed-dose amlodipine besylate/benazepril HCl versus comparable component-based therapy. Congest Heart Fail. 2003;9:324–332.PubMedCrossRefGoogle Scholar
  41. 41.
    Azrin NH, Teichner G. Evaluation of an instructional program for improving medication compliance for chronically mentally ill outpatients. Behav Res Ther. 1998;36:849–861.PubMedCrossRefGoogle Scholar
  42. 42.
    Frick PA, Lavreys L, Mandaliya K, Kreiss JK. Impact of an alarm device on medication compliance in women in Mombasa, Kenya. Inter J STD AIDS. 2001;12:329–333.CrossRefGoogle Scholar
  43. 43.
    Hoffman L, Enders J, Luo J, Segal R, Pippins J, Kimberlin C. Impact of an antidepressant management program on medication adherence. Am J Manag Care. 2003;9:70–80.PubMedGoogle Scholar
  44. 44.
    Jacobson TA, Thomas DM, Morton FJ, Offutt G, Shevlin J, Ray S. Use of a low-literacy patient education tool to enhance pneumococcal vaccination rates: a randomized controlled trial. JAMA. 1999;28:646–650.CrossRefGoogle Scholar
  45. 45.
    Laster SF, Martin JL, Fleming JB. The effect of a medication alarm device on patient compliance with topical pilocarpine. J Am Optom Assoc. 1996;67:654–658.PubMedGoogle Scholar
  46. 46.
    Perri M, Martin BC, Pritchard FL. Improving medication compliance: a practical intervention. J Pharm Technol. 1995;11:167–172.Google Scholar
  47. 47.
    Lipton HL, Bird JA. The impact of clinical pharmacists’ consultations on geriatric patients’ compliance and medical care use: a randomized controlled trial. Gerontologist. 1994;34:307–315.PubMedGoogle Scholar
  48. 48.
    Naunton M, Peterson GM. Evaluation of home-based follow-up of high-risk elderly patients discharged from hospital. J Pharm Pract Res. 2003;33:176–182.Google Scholar
  49. 49.
    Rich MW, Gray DB, Beckham V, Wittenberg C, Luther P. Effect of a multidisciplinary intervention on medication compliance in elderly patients with congestive heart failure. Am J Med. 1996;101: 270–276.PubMedCrossRefGoogle Scholar
  50. 50.
    Smith L, McGowan L, Moss-Barclay C, Wheater J, Knass D, Chrystyn H. An investigation of hospital generated pharmaceutical care when patients are discharged home from hospital. BrJClin Pharmacol. 1997;44:163–165.Google Scholar
  51. 51.
    Lee M, Kemp JA, Canning A, Egan C, Tataronis G, Farraye FA. A randomized controlled trial of an enhanced patient compliance program for Helicobacter pylori therapy. Arch Intern Med. 1999;159:2312–2316.PubMedCrossRefGoogle Scholar
  52. 52.
    Okonkwo PO, Akpala CO, Okafor HU, Mbah AU, Nwaiwu O. Compliance to correct dose of chloroquine in uncomplicated malaria correlates with improvement in the condition of rural Nigerian children. Trans R Soc Trop Med Hyg. 2001;95:320–324.PubMedCrossRefGoogle Scholar
  53. 53.
    Putnam DE, Finney JW, Barkley PL, Bonner MJ. Enhancing commitment improves adherence to a medical regimen. J Consul Clin Psychol. 1994;62:191–194.CrossRefGoogle Scholar
  54. 54.
    Berg J, Dunbar-Jacob J, Sereika SM. An evaluation of a self-management program for adults with asthma. Clin Nurs Res. 1997;6:225–238.PubMedCrossRefGoogle Scholar
  55. 55.
    Lowe CJ, Raynor DK, Courtney EA, Purvis J, Teale C. Effects of self medication programme on knowledge of drugs and compliance with treatment in elderly patients. BMJ. 1995;310:1229–1231.PubMedGoogle Scholar
  56. 56.
    Mehta S, Moore RD, Graham, NM. Potential factors affecting adherence with HIV therapy. AIDS. 1997;11:1665–1670.PubMedCrossRefGoogle Scholar
  57. 57.
    Venturini F, Nichol MB, Sung JC, Bailey KL, Cody M, McCombs JS. Compliance with sulfonylureas in a health maintenance organization: a pharmacy record-based study. Ann Pharmacother. 1999;33:281–288.PubMedCrossRefGoogle Scholar
  58. 58.
    Van Servellen G, Carpio F, Lopez M, et al. Program to enhance health literacy and treatment adherence in low-income HIV-infected Latino men and women. AIDS Patient Care STDs. 2003; 17:581–594.PubMedCrossRefGoogle Scholar
  59. 59.
    Agarwal MR, Sharma VK, KishoreKumar KV, Lowe D. Non-compliance with treatment in patients suffering from schizophrenia: a study to evaluate possible contributing factors. Int J Social Psychiatry. 1998;44:92–106.CrossRefGoogle Scholar
  60. 60.
    Branin, JJ. Correlates of Strategy Use in Medication Adherence Among Older Adults [dissertation]. Claremont, Calif: Claremont Graduate University; 2003.Google Scholar
  61. 61.
    Coldham EL, Addington J, Addington D. Medication adherence of individuals with a first episode of psychosis. Acta Psychiatr Scand. 2002;106:286–290.PubMedCrossRefGoogle Scholar
  62. 62.
    Daniels DE, Rene AA, Daniels VR. Race: an explanation of patient compliance—fact or fiction? J Nat Med Assoc. 1994;86:20–25.Google Scholar
  63. 63.
    DegliEsposti E, Sturani A, Di Martino M, et al. Long-term persistence with antihypertensive drugs in new patients. J Hum Hypertens. 2002;16:439–444.CrossRefGoogle Scholar
  64. 64.
    Peters KF, Horne R, Kong F, Francomano CA, Biesecker BB. Living with Marfan syndrome, II: medication adherence and physical activity modification. Clin Genet. 2001;60:283–292.PubMedCrossRefGoogle Scholar
  65. 65.
    Van Servellen G, Brown JS, Lombardi E, Herrera G. Health literacy in low-income Latino men and women receiving antiretroviral therapy in community-based treatment centers. AIDS Patient Care STDs. 2003;17:283–298.PubMedCrossRefGoogle Scholar
  66. 66.
    Wagner GJ. Predictors of antiretroviral adherence as measured by self-report, electronic monitoring, and medication diaries. AIDS Patient Care STDs. 2002;16:599–608.PubMedCrossRefGoogle Scholar
  67. 67.
    Ayres A, Hoon PW, Franzoni JB, et al. Influence of mood and adjustment to cancer on compliance with chemotherapy among breast cancer patients. J Psychosom Res. 1994;38:393–402.PubMedCrossRefGoogle Scholar
  68. 68.
    Brus H, vande Laar M, Taal E, Rasker J, Wiegman O. Determinants of compliance with medication in patients with rheumatoid arthritis: the importance of self-efficacy expectations. Patient Educ Counsel. 1999;36:57–64.CrossRefGoogle Scholar
  69. 69.
    Colom F, Vieta E, Martinez-Aran A, Reinares M, Benabarre A, Gasto C. Clinical factors associated with treatment noncompliance in euthymic bipolar patients. J Clin Psychiatry. 2000:61:549–555.PubMedCrossRefGoogle Scholar
  70. 70.
    Coons SJ, Sheahan SL, Martin SS, Hendricks J, Robbins CA, Johnson JA. Predictors of medication noncompliance in a sample of older adults. Clin Ther. 1994;16:110–117.PubMedGoogle Scholar
  71. 71.
    Dew MA, Roth LH, Thompson ME, Kormos RL, Griffith BP. Medical compliance and its predictors in the first year after heart transplantation. J Heart Lung Transplant. 1996;15:631–645.PubMedGoogle Scholar
  72. 72.
    Erlen JA, Sereika SM, Cook RL, Hunt SC. Adherence to antiretroviral therapy among women with HIV infection. J Obstet Gynecol Neonatal Nurs. 2002;31:470–477.PubMedCrossRefGoogle Scholar
  73. 73.
    Evangelista L, Doering LV, Dracup K, Westlake C, Hamilton M, Fonarow, GC. Compliance behaviors of elderly patients with advanced heart failure. J Cardiovasc Nurs. 2003;18:197–206.PubMedCrossRefGoogle Scholar
  74. 74.
    Kane SV, Cohen RD, Aikens JE, Hanauer SB. Prevalence of nonadherence with maintenance mesalamine in quiescent ulcerative colitis. Am J Gastroenterol. 2001;96:2929–2933.PubMedCrossRefGoogle Scholar
  75. 75.
    Kyngas H. Compliance with health regimens of adolescents with epilepsy. Seizure. 2000;9: 598–604.PubMedCrossRefGoogle Scholar
  76. 76.
    Kalichman SC, Ramachandran B, Catz S. Adherence to combination antiretroviral therapies in HIV patients of low health literacy. J Gen Intern Med. 1999;14:267–273.PubMedCrossRefGoogle Scholar
  77. 77.
    Gago C, Gruss E, Gonzalez S, et al. Compliance of haemodialysis patients with prescribed medication. EDTNA ERCA J. 2000;26:4–6.Google Scholar
  78. 78.
    Asawavichienjinda T, Sitthi-Amorn C, Tanyanont W. Compliance with treatment of adult epileptics in a rural district of Thailand. J Med Assoc Thail. 2003;86:46–51.Google Scholar
  79. 79.
    Kalichman SC, Catz S, Ramachandran B. Barriers to HIV/AIDS treatment and treatment adherence among African-American adults with disadvantaged education. J Nat Med Assoc. 1999;91:439–446.Google Scholar
  80. 80.
    Miller LG, Liu H, Hays RD, et al. Knowledge of antiretroviral regimen dosing and adherence: a longitudinal study. Clin Infect Dis. 2003;36:514–518.PubMedCrossRefGoogle Scholar
  81. 81.
    Wagner G. Placebo practice trials: the best predictor of adherence readiness for HAART among drug users? HIV Clin Trials. 2003;4:269–281.PubMedCrossRefGoogle Scholar
  82. 82.
    Pettinger MB, Waclawiw MA, Davis KB, et al. Compliance to multiple interventions in a high risk population. Ann Epidemiol. 1999;9:408–418.PubMedCrossRefGoogle Scholar
  83. 83.
    Van Servellen G, Chang B, Garcia L, Lombardi E. Individual and system level factors associated with treatment nonadherence in human immunodeficiency virus-infected men and women. AIDS Patient Care STDs. 2002;16:269–281.PubMedCrossRefGoogle Scholar
  84. 84.
    Cohen I, Rogers P, Burke V, Beilin LJ. Predictors of medication use, compliance and symptoms of hypotension in a community-based sample of elderly men and women. J Clin Pharm Ther. 1998;23:423–432.PubMedCrossRefGoogle Scholar
  85. 85.
    Embry LM. Predictors of Treatment Adherence in Pediatric Cancer Patients [dissertation]. Hattiesburg, Miss: University of Southern Mississippi; 2003.Google Scholar
  86. 86.
    Eddy ME, Carter BD, Kronenberger WG, et al. Parent relationships and compliance in cystic fibrosis. J Pediatr Health Care. 1998;12:196–202.PubMedCrossRefGoogle Scholar
  87. 87.
    Holzemer WL, Corless IB, Nokes KM, et al. Predictors of self-reported adherence in persons living with HIV disease. AIDS Patient Care STDs. 1999;13:185–197.PubMedCrossRefGoogle Scholar
  88. 88.
    Altice FL, Mostashari F, Friedland GH. Trust and the acceptance of adherence to antiretroviral therapy. J AIDS. 2001;28:47–58.Google Scholar
  89. 89.
    Anastasio GD, Little JM Jr, Robinson MD, Pettice YL, Leitch BB, Norton HJ. Impact of compliance and side effects on the clinical outcome of patients treated with oral erythromycin. Pharmacotherapy. 1994;14:229–234.PubMedGoogle Scholar
  90. 90.
    Bruckert E, Simonetta C, Giral P. Compliance with fluvastatin treatment: characterization of the noncompliant population within a population of 3845 patients with hyperlipidemia. CREOLE Study Team. J Clin Epidemiol. 1999;52:589–594.PubMedCrossRefGoogle Scholar
  91. 91.
    Fraser C, Hadjimichael O, Vollmer T. Predictors of adherence to copaxone therapy in individuals with relapsing-remitting multiple sclerosis. J Neurosci Nurs. 2001;33:231–239.PubMedGoogle Scholar
  92. 92.
    Cooper AE, Hanrahan P, Luchins DJ. Compliance with atypical antipsychotic regimens. Drug Benefit Trends. 2003;15:34–38.Google Scholar
  93. 93.
    Carney RM, Freedland KE, Eisen SA, Rich MW, Jaffe AS. Major depression and medication adherence in elderly patients with coronary artery disease. Health Psychol. 1995;14:88–90.PubMedCrossRefGoogle Scholar
  94. 94.
    Carrieri MP, Chesney MA, Spire B, et al. Failure to maintain adherence to HAART in a cohort of French HIV-positive injecting drug users. Inter J Behav Med. 2003;10:1–14.CrossRefGoogle Scholar
  95. 95.
    Gordillo V, delAmo J, Soriano V, Gonzalez-Lahoz J. Sociodemographic and psychological variables influencing adherence to antiretroviral therapy. AIDS Care. 1999;13:1763–1769.Google Scholar
  96. 96.
    Mohr DC, Goodkin DE, Likosky W, Gatto N, Baumann KA, Rudick RA. Treatment of depression improves adherence to interferon beta-1b therapy for multiple sclerosis. Arch Neurol. 1997; 54:531–533.PubMedGoogle Scholar
  97. 97.
    Wang PS, Bohn RL, Knight E, Glynn RJ, Mogun H, Avorn J. Noncompliance with antihypertensive medications: the impact of depressive symptoms and psychosocial factors. J Gen Intern Med. 2002; 17:504–511.PubMedCrossRefGoogle Scholar
  98. 98.
    Barat I, Andreasen F, Damsgaard EM. Drug therapy in the elderly: what doctors believe and patients actually do. Br J Clin Pharmacol. 2001;51:615–622.PubMedCrossRefGoogle Scholar
  99. 99.
    Cuffel BJ, Alford J, Fischer EP, Owen RR. Awareness of illness in schizophrenia and outpatient treatment adherence. J Nerv Ment Dis. 1996:84:653–659.CrossRefGoogle Scholar
  100. 100.
    Jeste SD, Patterson TL, Palmer BW, Dolder CR, Goldman S, Jeste DV. Cognitive predictors of medication adherence among middle-aged and older outpatients with schizophrenia. Schizophr Res. 2003;63:49–58.PubMedCrossRefGoogle Scholar
  101. 101.
    Conway SP, Pond MN, Hamnett T, Watson A. Compliance with treatment in adult patients with cystic fibrosis. Thorax. 1996;51:29–33.PubMedGoogle Scholar
  102. 102.
    Walsh JC, Horne R, Dalton M, Burgess AP, Gazzard BG. Reasons for non-adherence to antiretroviral therapy: patients’ perspectives provide evidence of multiple causes. AIDS Care. 2001;13:709–720.PubMedCrossRefGoogle Scholar
  103. 103.
    Auamnoy T. Self-efficacy and Non-adherence in Post-renal Transplant Patients [dissertation]. Iowa City, Iowa: University of Iowa; 2000.Google Scholar
  104. 104.
    Christensen AJ, Moran PJ, Lawton WJ, Stallman D, Voigts AL. Monitoring attentional style and medical regimen adherence in hemodialysis patients. Health Psych. 1997;16:256–262.CrossRefGoogle Scholar
  105. 105.
    Dodds JA. Anger, Hostility and Psychological Reactance: Implications for Intervention and Medical Adherence in the Coronary Patient [dissertation]. Kent, Ohio: Kent State University; 1997.Google Scholar
  106. 106.
    Penkower L, Dew MA, Ellis D, Sereika SM, Kitutu JM, Shapiro R. Psychological distress and adherence to the medical regimen among adolescent renal transplant recipients. Am J Transplant. 2003;3:1418–1425.PubMedCrossRefGoogle Scholar
  107. 107.
    Duncan JC, Rogers R. Medication compliance in patients with chronic schizophrenia: implications for the community management of mentally disordered offenders. J Forensic Sci. 1998; 43:1133–1137.PubMedGoogle Scholar
  108. 108.
    Patton K, Meyers J, Lewis BE. Enhancement of compliance among patients with hypertension. Am J Manag Care. 1997;3:1693–1698.PubMedGoogle Scholar
  109. 109.
    Laidlaw JK, Beeken JE, Whitney FW, Reyes AA. Contracting with outpatient hemodialysis patients to improve adherence to treatment. Anna J. 1999;26:37–40.PubMedGoogle Scholar
  110. 110.
    Segal E, Tamir A, Ish-Shalom S. Compliance of osteoporotic patients with different treatment regimens. Isr Med Assoc J. 2003;5:859–862.PubMedGoogle Scholar
  111. 111.
    Malcolm SE, Ng JJ, Rosen RK, Stone VE. An examination of HIV/AIDS patients who have excellent adherence to HAART. AIDS Care. 2003;15:251–261.PubMedCrossRefGoogle Scholar
  112. 112.
    McDonald-Miszczak L, Maki SA, Gould ON. Self-reported medication adherence and health status in late adulthood: the role of beliefs. Exp Aging Res. 2000;26:189–207.PubMedCrossRefGoogle Scholar
  113. 113.
    Budd RJ, Hughes IC, Smith JA. Health beliefs and compliance with antipsychotic medication. BrJClin Psychol. 1996;35:393–397.Google Scholar
  114. 114.
    Hargrave R, Remler MP. Noncompliance. J Nat Med Assoc. 1996;88:7, 11.Google Scholar
  115. 115.
    Lin CC, Liang CC. The relationship between health locus of control and compliance of hemodialysis patients. Kaohsiung J Med Sci. 1997;13:243–254.PubMedGoogle Scholar
  116. 116.
    Demyttenaere K, Mesters P, Boulanger B, et al. Adherence to treatment regimen in depressed patients treated with amitriptyline or fluoxetine. J Affect Disord. 2001;65:243–252.PubMedCrossRefGoogle Scholar
  117. 117.
    Lerman C, Rimer B, Trock B, Balshem A, Engstrom PF. Factors associated with repeat adherence to breast cancer screening. Prev Med. 1990;19:279–290.PubMedCrossRefGoogle Scholar
  118. 118.
    Horne R, Hankins M, Jenkins R. The Satisfaction with Information about Medicines Scale (SIMS): a new measurement tool for audit and research. Qual Health Care. 2001;10:135–140.PubMedCrossRefGoogle Scholar
  119. 119.
    Gao X, Nau DP, Rosenbluth SA, Scott V, Woodward C. The relationship of disease severity, health beliefs and medication adherence among HIV patients. AIDS Care. 2000;12:387–398.PubMedCrossRefGoogle Scholar
  120. 120.
    Breen R, Thornhill JT. Noncompliance with medication for psychiatric disorders: reasons and remedies. CNS Drugs. 1998;9:457–471.CrossRefGoogle Scholar
  121. 121.
    Ciechanowski PS, Katon WJ, Russo JE, Walker EA. The patient-provider relationship: attachment theory and adherence to treatment in diabetes. Am J Psychiatry. 2001;158:29–35.PubMedCrossRefGoogle Scholar
  122. 122.
    Olfson M, Mechanic D, Hansell S, Boyer CA, Walkup J, Weiden PJ. Predicting medication non-compliance after hospital discharge among patients with schizophrenia. Psychiatr Serv. 2000; 51:216–222.PubMedCrossRefGoogle Scholar
  123. 123.
    Taylor SA, Galbraith SM, Mills RP. Causes of non-compliance with drug regimens in glaucoma patients: a qualitative study. J Ocul Pharmacol Ther. 2002;18:401–409.PubMedCrossRefGoogle Scholar
  124. 124.
    Hausman A. Taking your medicine: relational steps to improving patient compliance. Health Market Q. 2001;19:49–71.CrossRefGoogle Scholar
  125. 125.
    Chadwick NB. The Therapeutic Alliance, Awareness, and Medication Compliance in the Treatment of Schizophrenia [dissertation]. Augusta, Ga: Medical College of Georgia; 2001.Google Scholar
  126. 126.
    Fenichel A. The Relationship Between Health Care Clinicians’ Relational Abilities and Psychosocial Orientation to Patient Care, and Patient Adherence With Medical Treatment [dissertation]. New York, NY: Columbia University; 1999.Google Scholar
  127. 127.
    Levine AM. Antiretroviral therapy: adherence. Clin Care Options HIV Online J. 1998;4:1–10.Google Scholar
  128. 128.
    Isaac LM, Tamblyn RM. Compliance and cognitive function: a methodological approach to measuring unintentional errors in medication compliance in the elderly. Gerontologist. 1993; 33:772–781.PubMedGoogle Scholar
  129. 129.
    Kasl SA, Cobb S. Health behavior, illness behavior, and sick role behavior, I: health and illness behavior. Arch Environ Health. 1966;12:246–266.PubMedGoogle Scholar
  130. 130.
    Carroll KM, Ball SA, Nich C, et al. Targeting behavioral therapies to enhance naltrexone treatment of opioid dependence: efficacy of contingency management and significant other involvement. Arch Gen Psychiatry. 2001;58:755–761.PubMedCrossRefGoogle Scholar
  131. 131.
    Cox LE. The Relative Influence of Social Support on the Medication Compliance of People With HIV Infection [dissertation]. Richmond, Va: Virginia Commonwealth University; 1998.Google Scholar
  132. 132.
    Moore SJ. Individuals’ Beliefs Concerning Adherence to Prescribed Antihypertensive Medication Regimens [dissertation]. Bloomington, Ind: Indiana University School of Nursing; 1995.Google Scholar
  133. 133.
    Bastardo YM, Kimberlin CL. Predicting adherence to antiretroviral therapy: an application of an extended theory of reasoned action (APS-P-203). International Pharmaceutical Federation— World Congress. 2002;62:73.Google Scholar
  134. 134.
    Adams J, Scott J. Predicting medication adherence in severe mental disorders. Acta Psychiatr Scand. 2000;101:119–124.PubMedCrossRefGoogle Scholar
  135. 135.
    Cohen NL, Parikh SV, Kennedy SH. Medication compliance in mood disorders: relevance of the health belief model and other determinants. Prim Care Psychiatry. 2000;6:101–110.CrossRefGoogle Scholar
  136. 136.
    Scott J. Using health belief models to understand the efficacy-effectiveness gap for mood stabilizer treatments. Neuropsychobiology. 2002;46(suppl 1):13–15.PubMedCrossRefGoogle Scholar
  137. 137.
    Steele RG, Anderson B, Rindel B, et al. Adherence to antiretroviral therapy among HIV-positive children: examination of the role of caregiver health beliefs. AIDS Care. 2001;13:617–629.PubMedCrossRefGoogle Scholar
  138. 138.
    Dracup KA, Meleis AI. Compliance: an interactionist approach. Nurs Res. 1982;31:31–36.PubMedCrossRefGoogle Scholar
  139. 139.
    Christensen AJ, Wiebe JS, Lawton WJ. Cynical hostility, powerful others control expectancies, and patient adherence in hemodialysis. Psychosom Med. 1997;59:307–312.PubMedGoogle Scholar
  140. 140.
    Berg J. An Evaluation of a Self-management Program for Adults With Asthma [thesis]. Pittsburgh, Pa: University of Pittsburgh; 1995.Google Scholar
  141. 141.
    Willey C, Redding C, Stafford J, et al. Stages of change for adherence with medication regimens for chronic disease: development and validation of a measure. Clin Ther. 2000:22:858–871.PubMedCrossRefGoogle Scholar
  142. 142.
    Miller WR, Rollnick S. Motivational Interviewing: Preparing People for Change. 2nd ed. New York, NY: The Guilford Press; 2002.Google Scholar
  143. 143.
    Berger BA, Hudmon KS, Liang H. Predicting treatment discontinuation among patients with multiple sclerosis: application of the transtheoretical model of change. J Am Pharm Assoc. 2004; 44:45–545.CrossRefGoogle Scholar
  144. 144.
    O’Donnell C, Donohoe G, Sharkey L, et al. Compliance therapy: a randomised controlled trial in schizophrenia. BMJ. 2003;327:834–838.PubMedCrossRefGoogle Scholar
  145. 145.
    Sellwood W, Barrowclough C, Tarrier N, Quinn J, Mainwaring J, Lewis S. Needs-based cognitivebehavioural family intervention for carers of patients suffering from schizophrenia: 12-month follow-up. Acta Psychiatr Scand. 2001;104:346–355.PubMedCrossRefGoogle Scholar
  146. 146.
    Kutcher S, Leblanc J, Maclaren C, Hadrava V. A randomized trial of a specific adherence enhancement program in sertraline-treated adults with major depressive disorder in a primary care setting. Prog Neuropsychopharmacol Biol Psychiatry. 2002;26:591–596.PubMedCrossRefGoogle Scholar
  147. 147.
    Rawlings MK, Thompson MA, Farthing CF, et al. Impact of an educational program on efficacy and adherence with a twice-daily lamivudine/zidovudine/abacavir regimen in underrepresented HIV-infected patients. J Acquir Immune Defic Syndr. 2003;34:174–183.PubMedCrossRefGoogle Scholar
  148. 148.
    Weinberger M, Murray MD, Marrero DG, et al. Effectiveness of pharmacist care for patients with reactive airways disease: a randomized controlled trial. JAMA. 2002;288:1594–1602.PubMedCrossRefGoogle Scholar
  149. 149.
    Capoccia KL, Boudreau DM, Blough DK, et al. Randomized trial of pharmacist interventions to improve depression care and outcomes in primary care. Am J Health-Syst Pharm. 2004;61: 364–372.PubMedGoogle Scholar
  150. 150.
    Hanlon JT, Weinberger M, Samsa GP, et al. A randomized, controlled trial of a clinical pharmacist intervention to improve inappropriate prescribing in elderly outpatients with polypharmacy. Am J Med. 1996;100:428–437.PubMedCrossRefGoogle Scholar
  151. 151.
    Owens D, Carroll A, Fattah S, Clyde Z, Coffey I, Johnstone E. A randomized, controlled trial of a brief interventional package for schizophrenic out-patients. Acta Psychiatr Scand. 2001; 103:362–369.CrossRefGoogle Scholar
  152. 152.
    Taylor CT, Byrd DC, Krueger K. Improving primary care in rural Alabama with a pharmacy initiative. Amer J Health-Syst Pharm. 2003;60:1123–1129.Google Scholar
  153. 153.
    Volume CI, Farris KB, Kassam R, Cox CE, Cave A. Pharmaceutical care research and education project: patient outcomes. J Am Pharm Assoc. 2001;41:411–420.Google Scholar
  154. 154.
    Claxton AJ, Cramer J, Pierce C. A systematic review of the associations between dose regimens and medication compliance. Clin Ther. 2001;23:1296–1310.PubMedCrossRefGoogle Scholar
  155. 155.
    Esposito L. The effects of medication education on adherence to medication regimens in an elderly population. J Adv Nurs. 1995;21:935–943.PubMedCrossRefGoogle Scholar
  156. 156.
    Madoff SA, Pristach CA, Smith CM, Pristach EA. Computerized medication instruction for psychiatric inpatients admitted for acute care. MD Comput. 1996;13:427–431, 441.PubMedGoogle Scholar
  157. 157.
    Nazareth I, Burton A, Shulman S, Smith P, Haines A, Timberal H. A pharmacy discharge plan for hospitalized elderly patients: a randomized controlled trial. Age Ageing. 2001;30:33–40.PubMedCrossRefGoogle Scholar
  158. 158.
    Williford SL, Johnson DF. Impact of pharmacist counseling on medication knowledge and compliance. Mil Med. 1995;160:561–564.PubMedGoogle Scholar
  159. 159.
    Bennett JW, Glasziou P, DelMar C, De Looze F. A computerized prescribing decision support system to improve patient adherence with prescribing: a randomized controlled trial. Austr Fam Physician. 2003;32:667–671.Google Scholar
  160. 160.
    Cegala DJ, Marinelli T, Post D. The effects of patient communication skills training on compliance. Arch Fam Med. 2000;9:57–64.PubMedCrossRefGoogle Scholar
  161. 161.
    Lourens H, Woodward MC. Impact of a medication card on compliance in older people. Aust J Ageing. 1994;13:72–76.Google Scholar
  162. 162.
    Stevens VJ, Shneidman RJ, Johnson RE, Boles M, Steele PE, Lee NL. Helicobacter pylori eradication in dyspeptic primary care patients: a randomized controlled trial of a pharmacy intervention. West J Med. 2002;176:92–96.PubMedGoogle Scholar
  163. 163.
    Vrijens B, Goetghebeur E. Comparing compliance patterns between randomized treatments. Controlled Clin Trials. 1997;18:187–203.PubMedCrossRefGoogle Scholar
  164. 164.
    Fogarty L, Roter D, Larson S, Burke J, Gillespie J, Levy R. Patient adherence to HIV medication regimens: a review of published and abstract reports. Patient Educ Counsel. 2002;46:93–108.CrossRefGoogle Scholar
  165. 165.
    Krueger KP, Felkey BG, Berger BA. Improving adherence and persistence: a review and assessment of interventions and description of steps toward a national adherence initiative. J Am Pharm Assoc. 2003;43:668–678.CrossRefGoogle Scholar
  166. 166.
    IOM Committee on Health and Literacy. The extent and associations of limited health literacy. In: Nielsen-Bohlman L, Panzer AM, Kindig DA, eds. Health Literacy: A Prescription to End Confusion. Washington, DC: National Academies Press; 2004:59–107.Google Scholar
  167. 167.
    Ebrahimzadeh H, Davalos R, Lee PP. Literacy levels of ophthalmic patient education materials. Surv Ophthalmol. 1997;42:152–156.PubMedCrossRefGoogle Scholar
  168. 168.
    Ortiz F, Fitten LJ. Barriers to healthcare access for cognitively impaired older Hispanics. Alzheimer Dis Assoc Disord. 2000;14:141–150.PubMedCrossRefGoogle Scholar
  169. 169.
    Weech-Maldonado R, Morales LS, Elliott M, Spritzer K, Marshall G, Hays RD. Race/ethnicity, language, and patients’ assessments of care in Medicaid managed care. Health Serv Res. 2003; 38:789–808.PubMedCrossRefGoogle Scholar
  170. 170.
    Xu KT, Rojas-Fernandez CH. Ancillary community pharmacy services provided to older people in a largely rural and ethnically diverse region: a survey of consumers in West Texas. J Rural Health. 2003;19:79–86.PubMedGoogle Scholar
  171. 171.
    John-Baptiste A, Naglie G, Tomlinson G, et al. The effect of English language proficiency on length of stay and in-hospital mortality. J Gen Intern Med. 2004;19:221–228.PubMedCrossRefGoogle Scholar
  172. 172.
    Schillinger D, Piette J, Grumbach K, et al. Closing the loop: physician communication with diabetic patients who have low health literacy. Arch Intern Med. 2003;163:83–90.PubMedCrossRefGoogle Scholar
  173. 173.
    Hussey LC. Minimizing effects of low literacy on medication knowledge and compliance among the elderly. Clin Nurs Res. 1994;3:132–145.PubMedCrossRefGoogle Scholar
  174. 174.
    Mulrow C, Bailey S, Sonksen PH, Slavin B. Evaluation of an audiovisual diabetes education program: negative results of a randomized trial of patients with non-insulin-dependent diabetes mellitus. J Gen Intern Med. 1987;2:215–219.PubMedCrossRefGoogle Scholar
  175. 175.
    Bultman DC, Svarstad BL. Effects of pharmacist monitoring on patient satisfaction with antidepressant therapy. J Am Pharm Assoc. 2002;42:36–43.CrossRefGoogle Scholar
  176. 176.
    Svarstad BL, Bultman DC, Mount JC, Tabak ER. Evaluation of written prescription information provided in community pharmacies: a study in eight states. J Am Pharm Assoc. 2003;43:383–393.CrossRefGoogle Scholar
  177. 177.
    Svarstad BL, Bultman DC, Mount JK. Patient counseling provided in community pharmacies: effects of state regulations, pharmacist age, and busyness. J Am Pharm Assoc. 2004;44:22–29.CrossRefGoogle Scholar
  178. 178.
    Sleath B, Chewning B, Svarstad B, Roter D. Patient expression of complaints and adherence problems with medications during chronic disease medical visits. J Soc Admin Pharm. 2000;17: 71–80.Google Scholar
  179. 179.
    Roter D. Advancing the physician’s contribution to enhancing compliance. J Pharmacoepidemiol. 1995;3:37–48.CrossRefGoogle Scholar
  180. 180.
    Haynes RB, McDonald PM, Garg AX. Helping patients follow prescribed treatment. JAMA. 2002; 288:2880–2883.PubMedCrossRefGoogle Scholar
  181. 181.
    Haynes RB, McKibbon KA, Kanani R. Systematic review of randomized trials of interventions to assist patients to follow prescriptions for medications. Lancet. 1996;348:383–386.PubMedCrossRefGoogle Scholar
  182. 182.
    Haynes RB. Strategies for enhancing patient compliance. Drug Ther. 1980;January:147–154.Google Scholar
  183. 183.
    McDonald PM, Garg AX, Haynes RB. Interventions to enhance patient adherence to medication regimens. JAMA. 2002;288:2868–2879.PubMedCrossRefGoogle Scholar
  184. 184.
    Prochaska JO. Systems of Psychotherapy: A Transtheoretical Analysis. Homewood, Ill: Dorsey Press; 1979.Google Scholar
  185. 185.
    Di Clemente CC, Prochaska JO. Self-change and therapy change of smoking behavior: a comparison of processes of change in cessation and maintenance. Addict Behav. 1982;7:133–142.CrossRefGoogle Scholar
  186. 186.
    Prochaska JO, Di Clemente CC. Common processes of self-change in smoking, weight control and psychological distress. In: Shiffman S, Wills, TA, eds. Coping and Substance Abuse. New York, NY: Academic Press; 345–363.Google Scholar
  187. 187.
    Norcross JC, Prochaska JO, Di Clemente CC. Self-change of psychological distress: laypersons’ vs psychologists’ coping strategies. J Clin Psychol. 1986;42:834–840.PubMedCrossRefGoogle Scholar
  188. 188.
    Di Clemente CC, Hughes SO. Stages of change profiles in outpatient alcoholism treatment. J Subst Abuse. 1990;2:217–235.CrossRefGoogle Scholar
  189. 189.
    Marcus BH, Banspach SW, Lefebvre RC, Rossi JS, Carleton RA, Abrams DB. Using the stages of change model to increase the adoption of physical activity among community participants. Am J Health Promot. 1992;6:424–429.PubMedGoogle Scholar
  190. 190.
    McConnaughy EA, Prochaska JO, Velicer WF. Stages of change in psychotherapy: measurement and sample profiles. Psychother Theory Res Pract. 1983;20:368–375.CrossRefGoogle Scholar
  191. 191.
    Swanson AJ, Pantalon MV, Cohen KR. Motivational interviewing and treatment adherence among psychiatric and dually diagnosed patients. J Nerv Ment Dis. 1997;187:630–635.CrossRefGoogle Scholar
  192. 192.
    Liang H. Decreasing Medication Dropout: A Study to Develop and Evaluate Intervention Software Using the Transtheoretical Model of Change and Motivational Interviewing [dissertation]. Auburn, Ala: Auburn University; 2003.Google Scholar
  193. 193.
    Noel OR. Adherence to Antihypertensive Medication Regimens: An Application of the Fishbein Behavioral Intention Model [dissertation]. Auburn, Ala: Auburn University; 1993.Google Scholar
  194. 194.
    Cattaneo MJ, Sengupta N, Nichol MB. Factors associated with compliance: analysis of the patient’s health belief model. In: Program and abstracts of the ASHP midyear clinical meeting; December, 1999; Reno, Nev. Abstract P-444E.Google Scholar
  195. 195.
    Daftary MN, Goolsby T, Dutta A, Delapenha RA. Possible factors influencing non-adherence to antiretrovirals in an ambulatory HIV population. In: Program and abstracts of the ASHP midyear clinical meeting; December 2002; Atlanta, Ga. Abstract p 618E.Google Scholar
  196. 196.
    Magura S, Laudet AB, Mahmood D, Rosenblum A, Knight E. Adherence to medication regimens and participation in dual-focus self-help groups. Psychiatr Serv. 2002;53:310–316.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science and Business Media and LLC 2005

Authors and Affiliations

  • Kem P. Krueger
    • 1
  • Bruce A. Berger
  • Bill Felkey
    • 2
  1. 1.University of WyomingLaramie
  2. 2.Auburn UniversityAuburn

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