Advances in Therapy

, Volume 24, Issue 2, pp 273–290

Therapy conversion to insulin detemir among patients with type 2 diabetes treated with oral agents: A modeling study of cost-effectiveness in the United States

  • William J. Valentine
  • K. M. Erny-Albrecht
  • J. A. Ray
  • S. Roze
  • D. Cobden
  • A. J. Palmer

Abstract

The aim of this study was to gain a preliminary indication of the long-term clinical and economic implications of converting treatment for patients with type 2 diabetes to insulin detemir±oral hypoglycemic agents (OHAs) in a routine clinical practice setting in the United States. With the use of outcome data and patient characteristics reported from an ongoing prospective observational trial, a validated computer simulation model of diabetes was used to project the clinical and cost outcomes associated with therapy conversion to insulin detemir over a 35-y period from (1) OHA only, (2) neutral protamine Hagedorn insulin (NPH)±OHA, and (3) insulin glargine±OHA. Cost-effectiveness was assessed from a third-party healthcare payer perspective for the year 2005. Costs and clinical outcomes were discounted at a rate of 3%. Treatment with insulin detemir±OHA was associated with increases in quality-adjusted life expectancy of 0.309, 0.350, and 0.333 quality-adjusted life-years (QALYs) versus treatment with OHA alone, NPH±OHA, and insulin glargine±OHA, respectively. Increases in pharmacy costs were partially offset by reduced complications, particularly renal complications and neuropathy. Projected incremental cost-effectiveness ratios were well within the range considered to represent good value in the United States, at $7412, $6269, and $3951 per QALY gained for treatment with Idet+-OHA versus OHA alone, NPH±OHA, and Iglarg±OHA, respectively. On the basis of preliminary evidence of short-term improvements in glycemic control and reduced hypoglycemia, therapy conversion to insulin detemir±OHA from OHA alone, NPH±OHA, or insulin glargine±OHA was projected to increase quality-adjusted life expectancy and to represent a cost-effective treatment option in the United States.

Keywords

insulin type 2 diabetes cost-effectiveness insulin detemir NPH insulin insulin glargine 

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Copyright information

© Springer Science and Business Media and LLC 2007

Authors and Affiliations

  • William J. Valentine
    • 1
  • K. M. Erny-Albrecht
    • 1
  • J. A. Ray
    • 1
  • S. Roze
    • 1
  • D. Cobden
    • 2
  • A. J. Palmer
    • 1
  1. 1.CORE-Centre for Outcomes Research, a unit of IMSAllschwilSwitzerland
  2. 2.Novo Nordisk, IncPrincetonUSA

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