The Indian Journal of Pediatrics

, Volume 65, Issue 1, pp 63–78 | Cite as

Early diagnosis and treatment of neonatal sepsis

  • Jeffrey S. Gerdes
  • Richard Polin
Symposium: Advances in Neonatology — I


Perinatally acquired bacterial neonatal sepsis is a low incidence, high risk disease with a relatively benign treatment. Accurate diagnosis is difficult because there is no definitive diagnostic test; even blood cultures have an unacceptably low sensitivity. Therefore, the clinician must accept that a number of neonates who do not have the disease will have treatment initiated for sepsis. In order to treat rapidly all infants with sepsis and to minimize therapy for those without infection, historical, clinical, and laboratory data can be used together in a management approach to achieve optimal results. A systemized approach using history, examination, sepsis screen laboratory tests, and cultures is presented to guide clinical management.

Key words

Bacterial sepsis Blood cultures Low sensitivity 


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Copyright information

© Dr. K C Chaudhuri Foundation 1998

Authors and Affiliations

  • Jeffrey S. Gerdes
    • 1
  • Richard Polin
    • 1
  1. 1.Division of Neonatology, Department of Pediatrics, Children’s Hospital of PhiladelphiaUniversity of Pennsylvania School of MedicinePhiladelphia

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